Gene/Proteome Database (LMPD)
LMPD ID
LMP012865
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
contactin 5
Gene Symbol
Synonyms
Nb-2;
Alternate Names
contactin-5; neural recognition molecule NB-2;
Chromosome
8
Map Location
8q11
Summary
neural adhesion molecule [RGD, Feb 2006]
Orthologs
Proteins
| contactin-5 precursor | |
|---|---|
| Refseq ID | NP_446198 |
| Protein GI | 16758574 |
| UniProt ID | P97527 |
| mRNA ID | NM_053746 |
| Length | 1099 |
| MASSWRLILFLSFTSCLSEYSEALSGLSTSYAALLRIKKSSTSSAFGSKSRPRYSSPSLGTLSVSPPSWRGAAQQYHSPVNLYHSPDAFRQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPSPTYRWLRNGTEIDLESDYRYSMIDGTFIINNPSESRDSGLYQCLATNTFGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPTTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQIYTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTANGVLAIHSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDREVLIECKPQGSPKPAISWRKGDKAVRGNKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASVSVKEPTRIELTPKRTELTVGESIVLNCKAMHDSSLDVTFYWTLKGQPIDFEKEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGGSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSDASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWKHVKESLGRPQGFEIGYWKDTEPEDSAETVRTRGNESFVMLTGLEGDTLYHLTVRAYNGAGYGPPSREVSATTKRHPPSEPPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSKGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYAGGKITSAQSTLHSLSKWSSVTLLLALMLPSSSW | |
| sig_peptide: 1..18 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (P97527.1) calculated_mol_wt: 2062 peptide sequence: MASSWRLILFLSFTSCLS mat_peptide: 19..1072 product: Contactin-5 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P97527.1) calculated_mol_wt: 115633 peptide sequence: EYSEALSGLSTSYAALLRIKKSSTSSAFGSKSRPRYSSPSLGTLSVSPPSWRGAAQQYHSPVNLYHSPDAFRQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPSPTYRWLRNGTEIDLESDYRYSMIDGTFIINNPSESRDSGLYQCLATNTFGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPTTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQIYTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTANGVLAIHSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDREVLIECKPQGSPKPAISWRKGDKAVRGNKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASVSVKEPTRIELTPKRTELTVGESIVLNCKAMHDSSLDVTFYWTLKGQPIDFEKEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGGSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSDASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWKHVKESLGRPQGFEIGYWKDTEPEDSAETVRTRGNESFVMLTGLEGDTLYHLTVRAYNGAGYGPPSREVSATTKRHPPSEPPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSKGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYAGGKITS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031225 | IEA:UniProtKB-KW | C | anchored component of membrane |
| GO:0005737 | IEA:Ensembl | C | cytoplasm |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0007155 | NAS:RGD | P | cell adhesion |
| GO:0007605 | IEA:Ensembl | P | sensory perception of sound |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed after birth, reaching a maximum at postnatal day 14 in the cerebrum and postnatal day 3 in the cerebellum. Then, it decreases abruptly thereafter (at protein level) |
| Function | Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system |
| Similarity | Belongs to the immunoglobulin superfamily. Contactin family |
| Similarity | Contains 4 fibronectin type-III domains |
| Similarity | Contains 6 Ig-like C2-type (immunoglobulin-like) domains |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Subunit | Interacts with PTPRG |
| Tissue Specificity | Specifically expressed in the nervous system. Expressed in cerebrum and cerebellum but at low level in spinal chord. In brain, it is expressed in highly restricted regions at postnatal day 7, such as the auditory pathway, including the cochlear nucleus, superior olive, inferior colliculus, medial geniculate nucleus and auditory cortex. Expressed in the accessory olfactory bulb, glomerular and mitral cell layers in the olfactory bulb, anterior thalamic nuclei, layers II-IV of the cerebral cortex, dentate gyrus of the hippocampus and external granule cells and Purkinje cells of the cerebellum. Also expressed in the piriform cortex, inferior olive and facial nucleus. Weakly or not expressed in other parts of the brain |
Identical and Related Proteins
Unique RefSeq proteins for LMP012865 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16758574 | RefSeq | NP_446198 | 1099 | contactin-5 precursor |
Identical Sequences to LMP012865 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16758574 | DBBJ | BAA13311.1 | 1099 | NB-2 [Rattus norvegicus] |
| GI:16758574 | GenBank | EDL78504.1 | 1099 | rCG31728 [Rattus norvegicus] |
| GI:16758574 | SwissProt | P97527.1 | 1099 | RecName: Full=Contactin-5; AltName: Full=Neural recognition molecule NB-2; Flags: Precursor [Rattus norvegicus] |
Related Sequences to LMP012865 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16758574 | DBBJ | BAA13311.1 | 1099 | NB-2 [Rattus norvegicus] |
| GI:16758574 | GenBank | EDL78504.1 | 1099 | rCG31728 [Rattus norvegicus] |
| GI:16758574 | SwissProt | P97527.1 | 1099 | RecName: Full=Contactin-5; AltName: Full=Neural recognition molecule NB-2; Flags: Precursor [Rattus norvegicus] |