Gene/Proteome Database (LMPD)
LMPD ID
LMP012871
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor coactivator 6
Gene Symbol
Synonyms
NRC; Aib3; PRIP; Trbp; RAP250;
Alternate Names
nuclear receptor coactivator 6; PPAR-interacting protein; activating signal cointegrator 2; amplified in breast cancer protein 3; thyroid hormone receptor binding protein; nuclear receptor-activating protein, 250 kDa; cancer-amplified transcriptional coactivator ASC-2; peroxisome proliferator-activated receptor-interacting protein;
Chromosome
3
Map Location
3q42
Summary
interacts with nuclear hormone receptors to activate gene transcription [RGD, Feb 2006]
Orthologs
Proteins
| nuclear receptor coactivator 6 | |
|---|---|
| Refseq ID | NP_001263643 |
| Protein GI | 454601639 |
| mRNA ID | NM_001276714 |
| Length | 2058 |
| MVLDDLPNFEDIYTSLCSSTMGDSEVEFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDTILQSVPGLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMNGPVVSGNSVRMEAGFPMASGPGLIRMTSPATVMMPQGGNASSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLPPAHHPMQPVPVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQLQTRPLQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGPMTTNQGWKKAPLPSPMQAQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLSQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPSQGPPSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTAATPGNSGALQLQANQSVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNINNQQAGSSGVPQVTLGSMQGQPQQGPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVSNSPSQVMGIQGQVLRPPGPSPHMAQQHTDPATTANNDVNLSQMMPDVSMQQTSMVPPHVQSMQGNSASGSHFSGHGVSFNAPFGGAPNGTQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKQKKKKPPRKKKNCHQDLNTPDSRPAGLEEVDQQSLPGEQGINLDNTGPKLPDFSNRPPGYPTQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQPQPQPPPPSQPQSQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRVPMQQSGNVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNSSSPLGEMPSLPEAGGSEVPSVSGGPSNMPSHLVVSQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTVSNPPNFAAPQAHKLDSVVVSSGKQSNPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTLLQNMELPRNVLVGPTPLANPPLSGSFPNNNGLNSQNPTVPAPAVGTVVEDNKESLNVPQDSDCQNSQGRKEQVNTELKAVPIQEAKMVVPEDQSKKDGQPLDPNKLPSVEENKTLMSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPAVSGEDLKKASVIPTLQDPSSKEPSNSLNLPHSNEPCSTLAHPELSEVSSNIAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAPNIQTGRPLVLSSRATPVPLPSPPCTSSPVVAPNPSVQQVKELNPDEASPQTNTSADQSTLPSSQPTTVVSPLLANSPGSSANRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGPGLETTTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMGPSSTSTGPILPGGALPTSVRSVVTTLVPSELISTAPTTKGNHGGITSEPLAGGLVEEKVGSHPELLPSIAPSQTLVPKESPATALQGSVGRPELEANAAIASGQSSEPKETVEKSKTPSRRNSRTEEPTMASENVENGHRKRSSRPASASSSTKDITGAVQSKRRKSK | |
Gene Information
Entrez Gene ID
Gene Name
nuclear receptor coactivator 6
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0043234 | IDA:RGD | C | protein complex |
| GO:0016922 | IDA:RGD | F | ligand-dependent nuclear receptor binding |
| GO:0030374 | IDA:RGD | F | ligand-dependent nuclear receptor transcription coactivator activity |
| GO:0042803 | IDA:RGD | F | protein homodimerization activity |
| GO:0046966 | ISS:UniProtKB | F | thyroid hormone receptor binding |
| GO:0030099 | ISS:UniProtKB | P | myeloid cell differentiation |
| GO:0045893 | IDA:RGD | P | positive regulation of transcription, DNA-templated |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026638 | Nuclear receptor coactivator 6 |
UniProt Annotations
Entry Information
Gene Name
nuclear receptor coactivator 6
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Domain | Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which is essential for the association with nuclear receptors. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivate expression in an agonist- and AF2-dependent manner. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway (By similarity). {ECO:0000250}. |
| Interaction | P03372:ESR1 (xeno); NbExp=2; IntAct=EBI-286271, EBI-78473; P10912:GHR (xeno); NbExp=2; IntAct=EBI-286271, EBI-286316; P19793:RXRA (xeno); NbExp=2; IntAct=EBI-286271, EBI-78598; P10827:THRA (xeno); NbExp=2; IntAct=EBI-286271, EBI-286285; P11473:VDR (xeno); NbExp=2; IntAct=EBI-286271, EBI-286357; |
| Ptm | Phosphorylated. {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Subunit | Monomer and homodimer. Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferase proteins EP300 and CREBBP, and with methyltransferase proteins NCOA6IP and PRMT2 (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta- tubulin (By similarity). Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012871 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 454601639 | RefSeq | NP_001263643 | 2058 | nuclear receptor coactivator 6 |
Identical Sequences to LMP012871 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:454601639 | GenBank | EDL85918.1 | 2058 | nuclear receptor coactivator 6 [Rattus norvegicus] |
| GI:454601639 | RefSeq | XP_006235358.1 | 2058 | PREDICTED: nuclear receptor coactivator 6 isoform X1 [Rattus norvegicus] |
| GI:454601639 | RefSeq | XP_006235359.1 | 2058 | PREDICTED: nuclear receptor coactivator 6 isoform X1 [Rattus norvegicus] |
| GI:454601639 | RefSeq | XP_008760517.1 | 2058 | PREDICTED: nuclear receptor coactivator 6 isoform X1 [Rattus norvegicus] |
Related Sequences to LMP012871 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:454601639 | GenBank | EDL85918.1 | 2058 | nuclear receptor coactivator 6 [Rattus norvegicus] |
| GI:454601639 | RefSeq | XP_006235358.1 | 2058 | PREDICTED: nuclear receptor coactivator 6 isoform X1 [Rattus norvegicus] |
| GI:454601639 | RefSeq | XP_008760517.1 | 2058 | PREDICTED: nuclear receptor coactivator 6 isoform X1 [Rattus norvegicus] |