Gene/Proteome Database (LMPD)

LMPD ID
LMP012873
Gene ID
116565
Species
Rattus norvegicus (Rat)
Gene Name
low density lipoprotein receptor-related protein associated protein 1
Gene Symbol
Lrpap1
Alternate Names
alpha-2-macroglobulin receptor-associated protein; RAP; alpha-2-MRAP; gp330-binding 45 kDa protein; low density lipoprotein receptor-related protein-associated protein 1;
Chromosome
14
Map Location
14q21

Proteins

alpha-2-macroglobulin receptor-associated protein precursor
Refseq ID NP_001162584
Protein GI 281182762
UniProt ID Q99068
mRNA ID NM_001169113
Length 360
MAPLRDRVSTLPRLQLLVLLLLPLLLVPQPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDGDGEKEAKLVHNLNVILARYGLDGRKDTQTVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIHEYNVLLDTLSRAEEGYENLLSPSDMTHIKSDTLASKHSELKDRLRSINQGLDRLRKVSHQGYGPATEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL
sig_peptide: 1..33 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3631 peptide sequence: MAPLRDRVSTLPRLQLLVLLLLPLLLVPQPIAG mat_peptide: 34..360 product: Alpha-2-macroglobulin receptor-associated protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99068.2) calculated_mol_wt: 38419 peptide sequence: HGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDGDGEKEAKLVHNLNVILARYGLDGRKDTQTVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIHEYNVLLDTLSRAEEGYENLLSPSDMTHIKSDTLASKHSELKDRLRSINQGLDRLRKVSHQGYGPATEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL

Gene Information

Entrez Gene ID
116565
Gene Name
low density lipoprotein receptor-related protein associated protein 1
Gene Symbol
Lrpap1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:Ensembl C extracellular region
GO:0005886 IEA:Ensembl C plasma membrane
GO:0048237 IDA:RGD C rough endoplasmic reticulum lumen
GO:0031982 IDA:RGD C vesicle
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0035473 IPI:RGD F lipase binding
GO:1900116 IEA:Ensembl P extracellular negative regulation of signal transduction
GO:1900222 IEA:Ensembl P negative regulation of beta-amyloid clearance
GO:0032091 IEA:Ensembl P negative regulation of protein binding
GO:0010916 IEA:Ensembl P negative regulation of very-low-density lipoprotein particle clearance

Domain Information

InterPro Annotations

Accession Description
IPR010483 Alpha-2-macroglobulin RAP, C-terminal
IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1

UniProt Annotations

Entry Information

Gene Name
low density lipoprotein receptor-related protein associated protein 1
Protein Entry
AMRP_RAT
UniProt ID
Q99068
Species
Rat

Comments

Comment Type Description
Caution Was originally thought to be Heymann nephritis antigen gp330
Function Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
Interaction Q924X6:Lrp8 (xeno); NbExp=2; IntAct=EBI-919734, EBI-432319; P98155:VLDLR (xeno); NbExp=2; IntAct=EBI-919734, EBI-9004309;
Similarity Belongs to the alpha-2-MRAP family
Subcellular Location Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138}. Cytoplasm . Cell surface . Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum (By similarity)
Subunit Present on cell surface forming a complex with the alpha- 2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012873 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
281182762 RefSeq NP_001162584 360 alpha-2-macroglobulin receptor-associated protein precursor

Identical Sequences to LMP012873 proteins

Reference Database Accession Length Protein Name
GI:281182762 GenBank AAH82020.1 360 Lrpap1 protein, partial [Rattus norvegicus]
GI:281182762 GenBank EDM00070.1 360 low density lipoprotein receptor-related protein associated protein 1, isoform CRA_a [Rattus norvegicus]
GI:281182762 SwissProt Q99068.2 360 RecName: Full=Alpha-2-macroglobulin receptor-associated protein; Short=Alpha-2-MRAP; AltName: Full=Gp330-binding 45 kDa protein; AltName: Full=Low density lipoprotein receptor-related protein-associated protein 1; Short=RAP; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012873 proteins

Reference Database Accession Length Protein Name
GI:281182762 GenBank AAH82020.1 360 Lrpap1 protein, partial [Rattus norvegicus]
GI:281182762 GenBank EDM00070.1 360 low density lipoprotein receptor-related protein associated protein 1, isoform CRA_a [Rattus norvegicus]
GI:281182762 SwissProt Q99068.2 360 RecName: Full=Alpha-2-macroglobulin receptor-associated protein; Short=Alpha-2-MRAP; AltName: Full=Gp330-binding 45 kDa protein; AltName: Full=Low density lipoprotein receptor-related protein-associated protein 1; Short=RAP; Flags: Precursor [Rattus norvegicus]