Gene/Proteome Database (LMPD)

LMPD ID
LMP012874
Gene ID
116568
Species
Rattus norvegicus (Rat)
Gene Name
gamma-glutamyltransferase 1
Gene Symbol
Ggt1
Synonyms
Ggt; Ggtp; GGLUT;
Alternate Names
gamma-glutamyltranspeptidase 1; GGT 1; glutathione hydrolase 1; leukotriene-C4 hydrolase; gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase;
Chromosome
20
Map Location
chromosome:20
EC Number
2.3.2.2
Summary
required in the glutathione metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ggt1

Proteins

gamma-glutamyltranspeptidase 1
Refseq ID NP_446292
Protein GI 145280505
UniProt ID P07314
mRNA ID NM_053840
Length 568
MKNRFLVLGLVAVVLVFVIIGLCIWLPTTSGKPDHVYSRAAVATDAKRCSEIGRDMLQEGGSVVDAAIASLLCMGLINAHSMGIGGGLFFTIYNSTTRKAEVINAREMAPRLANTSMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLARALDKKRDIIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGARAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAEVIEHPMSIGLGDSTLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPTAYYEPEFYLPDDGGTAHLSVVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFTNQFGVAPSPANFIKPGKQPLSSMCPSIIVDKDGKVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKNIDQVVTAGLKTRHHHTEVTPDFIAVVQAVVRTSGGWAAASDSRKGGEPAGY

Gene Information

Entrez Gene ID
116568
Gene Name
gamma-glutamyltransferase 1
Gene Symbol
Ggt1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0005887 TAS:RGD C integral component of plasma membrane
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0003840 IDA:RGD F gamma-glutamyltransferase activity
GO:0036374 ISS:UniProtKB F glutathione hydrolase activity
GO:0007568 IEP:RGD P aging
GO:0034599 IEP:RGD P cellular response to oxidative stress
GO:0006536 ISS:UniProtKB P glutamate metabolic process
GO:0006750 IEA:UniProtKB-KW P glutathione biosynthetic process
GO:0006751 ISS:UniProtKB P glutathione catabolic process
GO:0031179 IDA:RGD P peptide modification
GO:0032355 IEP:RGD P response to estradiol
GO:0032496 IEP:RGD P response to lipopolysaccharide
GO:0034612 IEP:RGD P response to tumor necrosis factor
GO:0031638 ISS:UniProtKB P zymogen activation

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko00460 Cyanoamino acid metabolism
rno00460 Cyanoamino acid metabolism
ko00480 Glutathione metabolism
rno00480 Glutathione metabolism
ko00430 Taurine and hypotaurine metabolism
rno00430 Taurine and hypotaurine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000101 Gamma-glutamyltranspeptidase
IPR029055 Nucleophile aminohydrolases, N-terminal

UniProt Annotations

Entry Information

Gene Name
gamma-glutamyltransferase 1
Protein Entry
GGT1_RAT
UniProt ID
P07314
Species
Rat

Comments

Comment Type Description
Catalytic Activity A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Catalytic Activity Glutathione + H(2)O = L-cysteinylglycine + L- glutamate.
Catalytic Activity Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
Enzyme Regulation Activated by autocatalytic cleavage
Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism (By similarity)
Pathway Sulfur metabolism; glutathione metabolism.
Ptm Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme
Ptm N-glycosylated on both chains; contains sialic acid residues. It is not known if the sialic acid residues are present on N- linked or on O-linked glycans.
Ptm O-glycosylated; close to the membrane anchor on the heavy chain and on the light chain. The sugar moieties are localized to the stretch Thr-28 to Ser-30. Contains sialic acid residues. It is not known if the sialic acid residues are present on N-linked or on O-linked glycans.
Sequence Caution Sequence=CAA27224.1; Type=Frameshift; Positions=66, 134; Evidence= ;
Similarity Belongs to the gamma-glutamyltransferase family
Subcellular Location Cell membrane ; Single-pass type II membrane protein .
Subunit Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
Tissue Specificity Detected in adult kidney and mammary gland, and in fetal liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012874 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145280505 RefSeq NP_446292 568 gamma-glutamyltranspeptidase 1

Identical Sequences to LMP012874 proteins

Reference Database Accession Length Protein Name
GI:145280505 EMBL CAA33483.1 568 unnamed protein product [Rattus sp.]
GI:145280505 GenBank AAH78768.1 568 Ggt1 protein [Rattus norvegicus]
GI:145280505 SwissProt P07314.4 568 RecName: Full=Gamma-glutamyltranspeptidase 1; Short=GGT 1; AltName: Full=Gamma-glutamyltransferase 1; AltName: Full=Glutathione hydrolase 1; AltName: Full=Leukotriene-C4 hydrolase; AltName: CD_antigen=CD224; Contains: RecName: Full=Gamma-glutamyltranspeptidase 1 heavy chain; Contains: RecName: Full=Gamma-glutamyltranspeptidase 1 light chain; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012874 proteins

Reference Database Accession Length Protein Name
GI:145280505 EMBL CAA33483.1 568 unnamed protein product [Rattus sp.]
GI:145280505 GenBank AAH78768.1 568 Ggt1 protein [Rattus norvegicus]
GI:145280505 SwissProt P07314.4 568 RecName: Full=Gamma-glutamyltranspeptidase 1; Short=GGT 1; AltName: Full=Gamma-glutamyltransferase 1; AltName: Full=Glutathione hydrolase 1; AltName: Full=Leukotriene-C4 hydrolase; AltName: CD_antigen=CD224; Contains: RecName: Full=Gamma-glutamyltranspeptidase 1 heavy chain; Contains: RecName: Full=Gamma-glutamyltranspeptidase 1 light chain; Flags: Precursor [Rattus norvegicus]