Gene/Proteome Database (LMPD)
LMPD ID
LMP012875
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
secretogranin III
Gene Symbol
Synonyms
SgIII;
Alternate Names
secretogranin-3; 1B1075;
Chromosome
8
Map Location
8q24
Summary
component of intracellular dense core vesicles [RGD, Feb 2006]
Orthologs
Proteins
| secretogranin-3 precursor | |
|---|---|
| Refseq ID | NP_446308 |
| Protein GI | 16758722 |
| UniProt ID | P47868 |
| mRNA ID | NM_053856 |
| Length | 471 |
| MGFLWTGSWILVLVLNSGPIQAFPKPEGSQDKSLHNRELSAERPLNEQIAEAEADKIKKTYPSESKPSESNFSSVDNLNLLKAITEKETVEKAKQSIRSSPFDNRLNVDDADSTKNRKLTDEYDSTKSGLDRKVQDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEEAPEKPTSRTENQDGKIPEKVTPVAATQDGFTNRENDDTVSNTLTLSNGLERRTNPHRDDDFEELQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDETIALQTKNKLEKNTTDSKSKLFPAPPEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNLGGKTDEAKGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAYVEKGILDKEEANAIKRIYSSL | |
| sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2403 peptide sequence: MGFLWTGSWILVLVLNSGPIQA mat_peptide: 23..471 product: Secretogranin-3 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P47868.1) calculated_mol_wt: 50798 peptide sequence: FPKPEGSQDKSLHNRELSAERPLNEQIAEAEADKIKKTYPSESKPSESNFSSVDNLNLLKAITEKETVEKAKQSIRSSPFDNRLNVDDADSTKNRKLTDEYDSTKSGLDRKVQDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEEAPEKPTSRTENQDGKIPEKVTPVAATQDGFTNRENDDTVSNTLTLSNGLERRTNPHRDDDFEELQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDETIALQTKNKLEKNTTDSKSKLFPAPPEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNLGGKTDEAKGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAYVEKGILDKEEANAIKRIYSSL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031410 | TAS:RGD | C | cytoplasmic vesicle |
| GO:0005576 | IEA:UniProtKB-KW | C | extracellular region |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026197 | Secretogranin III |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Subcellular Location | Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions, i.e. pH 5.5 and 10 mM Ca(2+). This binding is Ca(2+)-independent. In pituitary gonadotropes, located in large secretory granules. |
| Subunit | Interacts with CHGA; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2) |
| Tissue Specificity | Expression restricted to the brain and pituitary gland. Not detected in the adrenal gland |
Identical and Related Proteins
Unique RefSeq proteins for LMP012875 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16758722 | RefSeq | NP_446308 | 471 | secretogranin-3 precursor |
Identical Sequences to LMP012875 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16758722 | GenBank | AAA56637.1 | 471 | secretogranin III [Rattus norvegicus] |
| GI:16758722 | SwissProt | P47868.1 | 471 | RecName: Full=Secretogranin-3; AltName: Full=1B1075; AltName: Full=Secretogranin III; Short=SgIII; Flags: Precursor [Rattus norvegicus] |
Related Sequences to LMP012875 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16758722 | GenBank | AAA56637.1 | 471 | secretogranin III [Rattus norvegicus] |
| GI:16758722 | GenBank | EDL77778.1 | 471 | secretogranin III, isoform CRA_a [Rattus norvegicus] |
| GI:16758722 | SwissProt | P47868.1 | 471 | RecName: Full=Secretogranin-3; AltName: Full=1B1075; AltName: Full=Secretogranin III; Short=SgIII; Flags: Precursor [Rattus norvegicus] |