Gene/Proteome Database (LMPD)

LMPD ID
LMP012877
Gene ID
116645
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, activating protein
Gene Symbol
Plaa
Synonyms
Plap; PLA2P;
Alternate Names
phospholipase A-2-activating protein;
Chromosome
5
Map Location
5q33
Summary
may play a role in phospholipase activation, production of prostaglandins, and regulation of inflammatory response [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Plaa

Proteins

phospholipase A-2-activating protein
Refseq ID NP_446318
Protein GI 158341684
UniProt ID P54319
mRNA ID NM_053866
Length 795
MASGAARYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLGVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTEADERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMAGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGSAPEEKKLTEDDLVLLEKILSLICGNASEKPTAQQLQVLWKAINWPEDIVFPALDILRLSIKHPSVNENFCNEKEGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYASVSEPAKVSECCRLILNLL

Gene Information

Entrez Gene ID
116645
Gene Name
phospholipase A2, activating protein
Gene Symbol
Plaa
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016005 IEA:Ensembl F phospholipase A2 activator activity
GO:0006954 IEA:Ensembl P inflammatory response

KEGG Pathway Links

KEGG Pathway ID Description
ko04141 Protein processing in endoplasmic reticulum
rno04141 Protein processing in endoplasmic reticulum

Domain Information

InterPro Annotations

Accession Description
IPR015155 PLAA family ubiquitin binding, PFU
IPR013535 PUL
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, activating protein
Protein Entry
PLAP_RAT
UniProt ID
P54319
Species
Rat

Comments

Comment Type Description
Domain The PFU domain mediates interaction with ubiquitin
Domain The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus
Function Involved in the maintenance of ubiquitin levels
Sequence Caution Sequence=AAA79979.1; Type=Frameshift; Positions=698; Evidence= ;
Similarity Belongs to the WD repeat PLAP family
Similarity Contains 1 PFU domain. {ECO:0000255|PROSITE- ProRule:PRU00727}.
Similarity Contains 1 PUL domain. {ECO:0000255|PROSITE- ProRule:PRU00729}.
Similarity Contains 6 ARM repeats
Similarity Contains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subunit Interacts with ubiquitin. Interacts with VCP (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012877 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158341684 RefSeq NP_446318 795 phospholipase A-2-activating protein

Identical Sequences to LMP012877 proteins

Reference Database Accession Length Protein Name
GI:158341684 GenBank EDL97756.1 795 phospholipase A2, activating protein, isoform CRA_b [Rattus norvegicus]
GI:158341684 SwissProt P54319.3 795 RecName: Full=Phospholipase A-2-activating protein; Short=PLA2P; Short=PLAP [Rattus norvegicus]

Related Sequences to LMP012877 proteins

Reference Database Accession Length Protein Name
GI:158341684 GenBank EDL97755.1 844 phospholipase A2, activating protein, isoform CRA_a [Rattus norvegicus]
GI:158341684 GenBank EDL97756.1 795 phospholipase A2, activating protein, isoform CRA_b [Rattus norvegicus]
GI:158341684 SwissProt P54319.3 795 RecName: Full=Phospholipase A-2-activating protein; Short=PLA2P; Short=PLAP [Rattus norvegicus]