Gene/Proteome Database (LMPD)

LMPD ID
LMP012879
Gene ID
116676
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 1 family, member A2
Gene Symbol
Aldh1a2
Synonyms
Raldh-2;
Alternate Names
retinal dehydrogenase 2; ralDH2; RALDH 2; RalDH(II); aldehyde dehydrogenase 1A2; retinal dehydrogenase, type II; aldehyde dehydrogenase family 1 member A2; retinaldehyde-specific dehydrogenase type 2; aldehyde dehydrogenase family 1, subfamily A2;
Chromosome
8
Map Location
8q24
EC Number
1.2.1.36
Summary
enzyme necessary for the production of retinoic acid; may be associated with congenital diaphragmatic hernia [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Aldh1a2

Proteins

retinal dehydrogenase 2
Refseq ID NP_446348
Protein GI 225735575
UniProt ID Q63639
mRNA ID NM_053896
Length 518
MTSSEIAMPGEVKADPAALMASLQLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS

Gene Information

Entrez Gene ID
116676
Gene Name
aldehyde dehydrogenase 1 family, member A2
Gene Symbol
Aldh1a2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0004028 IEA:Ensembl F 3-chloroallyl aldehyde dehydrogenase activity
GO:0016918 IDA:RGD F retinal binding
GO:0001758 IDA:RGD F retinal dehydrogenase activity
GO:0042904 IEA:Ensembl P 9-cis-retinoic acid biosynthetic process
GO:0009952 IEA:Ensembl P anterior/posterior pattern specification
GO:0001568 IEA:Ensembl P blood vessel development
GO:0048738 IEA:Ensembl P cardiac muscle tissue development
GO:0071300 IEA:Ensembl P cellular response to retinoic acid
GO:0009855 IEA:Ensembl P determination of bilateral symmetry
GO:0031076 IEA:Ensembl P embryonic camera-type eye development
GO:0048566 IEA:Ensembl P embryonic digestive tract development
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0060324 IEA:Ensembl P face development
GO:0003007 IEA:Ensembl P heart morphogenesis
GO:0030902 IEA:Ensembl P hindbrain development
GO:0001822 IEP:RGD P kidney development
GO:0001889 IEP:RGD P liver development
GO:0030324 IEA:Ensembl P lung development
GO:0007494 IEP:RGD P midgut development
GO:0016331 IEA:Ensembl P morphogenesis of embryonic epithelium
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0014032 IEA:Ensembl P neural crest cell development
GO:0021915 IEA:Ensembl P neural tube development
GO:0030182 IEA:Ensembl P neuron differentiation
GO:0031016 IEA:Ensembl P pancreas development
GO:0021983 IEP:RGD P pituitary gland development
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0010628 IEA:Ensembl P positive regulation of gene expression
GO:0009954 IEA:Ensembl P proximal/distal pattern formation
GO:0001936 IEA:Ensembl P regulation of endothelial cell proliferation
GO:0034097 IEA:Ensembl P response to cytokine
GO:0032355 IEP:RGD P response to estradiol
GO:0033189 IEP:RGD P response to vitamin A
GO:0042574 IEA:Ensembl P retinal metabolic process
GO:0002138 IMP:RGD P retinoic acid biosynthetic process
GO:0042573 IDA:RGD P retinoic acid metabolic process
GO:0048384 IEA:Ensembl P retinoic acid receptor signaling pathway
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process
GO:0035799 IEA:Ensembl P ureter maturation

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00830 Retinol metabolism
rno00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 1 family, member A2
Protein Entry
AL1A2_RAT
UniProt ID
Q63639
Species
Rat

Comments

Comment Type Description
Catalytic Activity Retinal + NAD(+) + H(2)O = retinoate + NADH.
Function Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.
Pathway Cofactor metabolism; retinol metabolism.
Sequence Caution Sequence=AAC52637.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the aldehyde dehydrogenase family
Subcellular Location Cytoplasm.
Subunit Homotetramer.
Tissue Specificity Found in testis and less abundantly in lung, brain, heart, liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP012879 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
225735575 RefSeq NP_446348 518 retinal dehydrogenase 2

Identical Sequences to LMP012879 proteins

Reference Database Accession Length Protein Name
GI:225735575 GenBank AAH98910.1 518 Aldh1a2 protein [Rattus norvegicus]
GI:225735575 GenBank EDL84165.1 518 aldehyde dehydrogenase family 1, subfamily A2 [Rattus norvegicus]
GI:225735575 SwissProt Q63639.2 518 RecName: Full=Retinal dehydrogenase 2; Short=RALDH 2; Short=RalDH2; AltName: Full=Aldehyde dehydrogenase family 1 member A2; AltName: Full=Retinaldehyde-specific dehydrogenase type 2; Short=RALDH(II) [Rattus norvegicus]

Related Sequences to LMP012879 proteins

Reference Database Accession Length Protein Name
GI:225735575 GenBank AAH98910.1 518 Aldh1a2 protein [Rattus norvegicus]
GI:225735575 GenBank EDL84165.1 518 aldehyde dehydrogenase family 1, subfamily A2 [Rattus norvegicus]
GI:225735575 SwissProt Q63639.2 518 RecName: Full=Retinal dehydrogenase 2; Short=RALDH 2; Short=RalDH2; AltName: Full=Aldehyde dehydrogenase family 1 member A2; AltName: Full=Retinaldehyde-specific dehydrogenase type 2; Short=RALDH(II) [Rattus norvegicus]