Gene/Proteome Database (LMPD)

LMPD ID
LMP012881
Gene ID
116696
Species
Rattus norvegicus (Rat)
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Gene Symbol
St8sia4
Synonyms
Siat8d;
Alternate Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; polysialyltransferase; sialyltransferase 8 (alpha-2, 8-sialytransferase) D; sialyltransferase 8 (alpha-2 8-polysialytransferase) D; sialyltransferase 8 (alpha-2 8-polysialyltransferase) D; sialyltransferase 8 (alpha-2, 8-polysialytransferase) D; sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D;
Chromosome
9
Map Location
9q36
Summary
enzyme involved in polysialylation of N-CAM [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for St8sia4

Proteins

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Refseq ID NP_446366
Protein GI 122425617
UniProt ID A1KQY6
mRNA ID NM_053914
Length 454
MHKVSHLKRNPSPREAAQSDPSPASANCAAGRWAALENRESSTAERPSDLILGSRLHAPFANFRFLPLDYFPKTEPLYQEKVPELGQPGLSRAPKMRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCLSRSLVNNSDKITRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCMKQ

Gene Information

Entrez Gene ID
116696
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Gene Symbol
St8sia4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003828 IEA:Ensembl F alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 TAS:RGD F sialyltransferase activity
GO:0001574 IEA:Ensembl P ganglioside biosynthetic process
GO:0007162 TAS:RGD P negative regulation of cell adhesion
GO:0006491 IEA:Ensembl P N-glycan processing
GO:0097503 TAS:GOC P sialylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953739 Asparagine N-linked glycosylation
5953532 Axon guidance
5953738 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5953533 Developmental Biology
5953345 Metabolism of proteins
5954138 NCAM1 interactions
5953531 NCAM signaling for neurite out-growth
5953728 Post-translational protein modification
5954270 Sialic acid metabolism
5953737 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29

UniProt Annotations

Entry Information

Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Protein Entry
A1KQY6_RAT
UniProt ID
A1KQY6
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012881 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
122425617 RefSeq NP_446366 454 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Identical Sequences to LMP012881 proteins

Reference Database Accession Length Protein Name
GI:122425617 EMBL CAL91579.1 454 alpha 2,8-sialyltransferase ST8Sia IV [Rattus norvegicus]
GI:122425617 GenBank EDL91890.1 454 rCG55449 [Rattus norvegicus]

Related Sequences to LMP012881 proteins

Reference Database Accession Length Protein Name
GI:122425617 EMBL CAL91579.1 454 alpha 2,8-sialyltransferase ST8Sia IV [Rattus norvegicus]
GI:122425617 GenBank EDL91890.1 454 rCG55449 [Rattus norvegicus]
GI:122425617 GenBank EGW01320.1 454 CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase [Cricetulus griseus]