Gene/Proteome Database (LMPD)

LMPD ID
LMP012882
Gene ID
116699
Species
Rattus norvegicus (Rat)
Gene Name
inositol polyphosphate-4-phosphatase, type II
Gene Symbol
Inpp4b
Alternate Names
type II inositol 3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II; type II inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate-4-phosphatase type II 105kD; inositol polyphosphate-4-phosphatase, type II, 105kD;
Chromosome
19
Map Location
19q11
EC Number
3.1.3.66
Summary
enzyme that catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Inpp4b

Proteins

type II inositol 3,4-bisphosphate 4-phosphatase
Refseq ID NP_446369
Protein GI 16758796
UniProt ID Q9QWG5
mRNA ID NM_053917
Length 942
MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKSPNEPQLEFILACKDLVAPVSDRKLNTVVQVSVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPSDYPIYEETRIKLTVYDVKDKPHDTIRTSVLPEHKDPPPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALVYDSTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRNNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLVATHADLLLTSASQHSPDSLRSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILRKPPSPKVSTEEKSSQHDSPQQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSRNDKSTGGDSSKDGDADPNLEDSLTSHPREDWYEQLHPLILTLKECMAEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLSDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ

Gene Information

Entrez Gene ID
116699
Gene Name
inositol polyphosphate-4-phosphatase, type II
Gene Symbol
Inpp4b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0008289 IEA:Ensembl F lipid binding
GO:0034594 IEA:Ensembl F phosphatidylinositol trisphosphate phosphatase activity
GO:0016316 IDA:RGD F phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597 IEA:UniProtKB-EC F phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0006874 IEA:Ensembl P cellular calcium ion homeostasis
GO:0045671 IEA:Ensembl P negative regulation of osteoclast differentiation
GO:0036092 IDA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0046850 IEA:Ensembl P regulation of bone remodeling
GO:0046822 IEA:Ensembl P regulation of nucleocytoplasmic transport
GO:0051896 IEA:Ensembl P regulation of protein kinase B signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954516 Synthesis of IP2, IP, and Ins in the cytosol
5954503 Synthesis of PIPs at the early endosome membrane
5954499 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-4-phosphatase, type II
Protein Entry
INP4B_RAT
UniProt ID
Q9QWG5
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q9QWG5-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9QWG5-2; Sequence=VSP_015249; Note=Inactive.;
Biophysicochemical Properties Kinetic parameters: KM=39 uM for inositol 3,4-bisphosphate ; KM=34 uM for inositol 1,3,4-trisphosphate ; Vmax=26 umol/min/mg enzyme with inositol 3,4-bisphosphate as substrate ; Vmax=22 umol/min/mg enzyme with inositol 1,3,4-trisphosphate as substrate ; pH dependence: Optimum pH is 7-8. ;
Catalytic Activity 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme Regulation Strongly inhibited by inositol hexakisphosphate
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.
Pathway Signal transduction; phosphatidylinositol signaling pathway.
Similarity Belongs to the inositol 3,4-bisphosphate 4-phosphatase family
Similarity Contains 1 C2 domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012882 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758796 RefSeq NP_446369 942 type II inositol 3,4-bisphosphate 4-phosphatase

Identical Sequences to LMP012882 proteins

Reference Database Accession Length Protein Name
GI:16758796 GenBank AAB72152.1 942 inositol polyphosphate 4-phosphatase type II-beta [Rattus norvegicus]
GI:16758796 GenBank EDL92295.1 942 inositol polyphosphate-4-phosphatase, type II, isoform CRA_c [Rattus norvegicus]
GI:16758796 RefSeq XP_008770684.1 942 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [Rattus norvegicus]

Related Sequences to LMP012882 proteins

Reference Database Accession Length Protein Name
GI:16758796 GenBank AAB72152.1 942 inositol polyphosphate 4-phosphatase type II-beta [Rattus norvegicus]
GI:16758796 GenBank EDL92295.1 942 inositol polyphosphate-4-phosphatase, type II, isoform CRA_c [Rattus norvegicus]
GI:16758796 RefSeq XP_008770684.1 942 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [Rattus norvegicus]