Gene/Proteome Database (LMPD)

LMPD ID
LMP012885
Gene ID
116720
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Gene Symbol
Pik3c2g
Alternate Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2gamma; PI3K-C2-gamma; ptdIns-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma; phosphoinositide 3-Kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide;
Chromosome
4
Map Location
4q44
EC Number
2.7.1.154
Summary
catalyzes the addition of a phosphate group to the 3' position for phosphotidylinositol and PtdIns 4-P substrates, but not for PtdIns 4,5-P2 [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pik3c2g

Proteins

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Refseq ID NP_446375
Protein GI 16758806
UniProt ID O70173
mRNA ID NM_053923
Length 1505
MAYNWQTEPNRAEPQEGGHDHQQCHHADQHLSSRQVRLGFDQLVEELSNKTPLPEDEKEGTCFVPDTPNLDSKWQSIYGPHPRHFNEFTSQSPHFSQLPFGKASAIGFNPAVLPAHQFIHEGASWRNPTRKYHGGEDPRFSALTPSSTGLDKCHQQGQSGTEHCNYYVEPENNVPHHYSPYSMDSIPDSEEKGSGDADLVEPSLVFSKDSFLPRASENMSVESTEPIGCPLEIVEAPQGSNKSLASFCNNVTKIRGLYHASDTNSNSGKIWAITTAYPSRLFADTQFRVKISTDNSAQLLLLKPPANYLVKDLIAEILLLCANEQLSPKEYLLSICGSEEFLQTDHCLGSHKIFQKSKSVIQLHLQRSRDTPGKLSRKRDDDRSRVHLNQLLEFTHIWKISRQCLSTVMKSYNLHVEHLLKTQEDVEEKPLSSMFSCGRHPPQPHGNDIIEDVRNICSVLGCIETKQVSDAVKELTLILQRPSQNFHQNSETSKKGFIENVTSELSRSLHQLVDVYCSSFCTDFRPARAPGGVSRDHAGLHSHLSFTVCSLHNVPETWAHSYKAFSFSCWLTYAGKKLCQVKSCRSLPVTKSFSFSVNWNEIINFPLEIKSLPRESMLVIKLFGIDSATHSANLLAWTCLPLFPKEKSPLGSRLLSMTLQSEPPIEMMAPGVWDGSQPTPLTLQIDFPAATWEYVKPETEENRTDHQEPPRECLKHIARLSQKQPPLLLSVEKRRYLWFYRFYCNNENSSLPLVLGSAPGWDEGTVSEMHAVLRRWTFSHPLEALGLLTSRFPDQDIREVAVQQLDNFLTDELLDCLPQLVQAVKFEWSLESPLVELLLHRSLQSIRVAHRLFWLLRDAQGEDYFKSWYQELLAALQFCAGEALIEELSKEQKLVKLLGDIGEKVKSAGDAQRKDVLKKEIGSLEEFFKDIKTCHLPLNPALCVKGIDRDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLKEDYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNTQHFQDFVELCCRAYNIVRKHSQLLLSLLEMMLHAGLPELRGIEDLKYVHDNLRPQDTDLEATSHFTTKIKQSLECFPVKLNNLIHTLAQMPAFSLARPAPQTPPQECCVLNKTRTIQRVTILGFSKTHSNLYLIEVTRSDNRKNLAKKSFEQFYRLHSQIQKQFPLLTLPEFPHWWHLPFTDSHHERIRDLSHYVEQVLHGSYEVANSDCVLSFFLSEHIQQTLEDSPFVDPGDHSPDKSPQVQLLMTYEDTKLTILVKHLKNIHLPDGSAPSAHVEIYLLPHPSEVRRKKTKCVPKCTDPTYNEIVVYDDVSGLQGHVLMLIVKSKTVFVGAVNIQLCSVPLNEEKWYPLGNSII

Gene Information

Entrez Gene ID
116720
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Gene Symbol
Pik3c2g
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:RGD C Golgi apparatus
GO:0005635 IDA:RGD C nuclear envelope
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0005886 IDA:RGD C plasma membrane
GO:0016303 IBA:RefGenome F 1-phosphatidylinositol-3-kinase activity
GO:0035005 IDA:RGD F 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0006935 IEA:UniProtKB-KW P chemotaxis
GO:0036092 IBA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Protein Entry
P3C2G_RAT
UniProt ID
O70173
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
Developmental Stage Higher levels of expression found in adult liver than in fetal liver
Function Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00879, ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 C2 domain
Similarity Contains 1 PI3K-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00879}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Similarity Contains 1 PX (phox homology) domain
Subcellular Location Membrane ; Peripheral membrane protein .
Tissue Specificity Predominantly expressed in normal liver. High levels also found in regenerating liver. Very low levels found in heart and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012885 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758806 RefSeq NP_446375 1505 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Identical Sequences to LMP012885 proteins

Reference Database Accession Length Protein Name
GI:16758806 DBBJ BAA25634.1 1505 phosphoinositide 3-kinase [Rattus norvegicus]
GI:16758806 SwissProt O70173.1 1505 RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Short=PI3K-C2-gamma; Short=PtdIns-3-kinase C2 subunit gamma; AltName: Full=Phosphoinositide 3-kinase-C2-gamma [Rattus norvegicus]

Related Sequences to LMP012885 proteins

Reference Database Accession Length Protein Name
GI:16758806 DBBJ BAA25634.1 1505 phosphoinositide 3-kinase [Rattus norvegicus]
GI:16758806 RefSeq XP_008761570.1 1539 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [Rattus norvegicus]
GI:16758806 SwissProt O70173.1 1505 RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Short=PI3K-C2-gamma; Short=PtdIns-3-kinase C2 subunit gamma; AltName: Full=Phosphoinositide 3-kinase-C2-gamma [Rattus norvegicus]