Gene/Proteome Database (LMPD)

LMPD ID
LMP012894
Gene ID
117265
Species
Rattus norvegicus (Rat)
Gene Name
peroxisomal biogenesis factor 6
Gene Symbol
Pex6
Synonyms
Paf2; Paf-2;
Alternate Names
peroxisome assembly factor 2; peroxin-6; peroxisomal-type ATPase 1;
Chromosome
9
Map Location
9q12
Summary
plays a role in peroxisome biogenesis and assembly [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pex6

Proteins

peroxisome assembly factor 2
Refseq ID NP_476466
Protein GI 16923976
UniProt ID P54777
mRNA ID NM_057125
Length 978
MALAVLHVLEPFPTETPPLAVLLPPGGPWPVTGVGLVLALRPASESPAGPALLVAAVEGSGAQCEQRGPGPPPLLVSRTLLRVLALSPGARVRARPVRRPPALGWALLGTSPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTELQGRTKLDPESRDHNHPPPPPVVSSFAVSHSIRQLRGVLGGTGDALGVSRSCLRSLGLFQGEWVWVARVGELPNTSQPHLAQVQVLEPRWDLSARLGPNSGQPGEPLADGLVFVPATLAFNLGCDPLEVGELRIQRYLEDSTAAEDKGSCSLLPGPPFARELHIEVLPSPHCGVNGKYDHVLYQHFHTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREVFFKVKKTVGEAPDGPASAFLADTTHTSLYLAGTTLSRVPPLPSGRSPPWDSLSPPGLEALVNELCAVLKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRTVETKLQTTFSRARRCRPVVLLLTALDLLGRDRDGLGEDARVVATLRHLLLDEDPLSRCPPLMVVATTSRVQDLPTDVRTAFPHELEVPVLSESQRLSVLQALTAHLPLGQEVNLSQLARRCAGFVVGDLYALLTHASRAACTRIKAAGLAMSEEDEGELCAAGFPLLAEDFGQALDQLQTAHSQAVGAPKIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLMNVLDCCPPQLTGADLYSLCSDAMMTALKRRVRDLEEGLEPRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC

Gene Information

Entrez Gene ID
117265
Gene Name
peroxisomal biogenesis factor 6
Gene Symbol
Pex6
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005778 IDA:HGNC C peroxisomal membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042623 IEA:Ensembl F ATPase activity, coupled
GO:0007031 IMP:RGD P peroxisome organization
GO:0016561 IEA:Ensembl P protein import into peroxisome matrix, translocation
GO:0050821 IEA:Ensembl P protein stabilization

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
rno04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR003960 ATPase, AAA-type, conserved site
IPR003959 ATPase, AAA-type, core
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
peroxisomal biogenesis factor 6
Protein Entry
PEX6_RAT
UniProt ID
P54777
Species
Rat

Comments

Comment Type Description
Function Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity)
Similarity Belongs to the AAA ATPase family
Subcellular Location Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes.
Subunit Interacts directly with PEX26 and PEX1. Mediates the indirect interaction between PEX1 and PEX26. Interacts with ZFAND6 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012894 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16923976 RefSeq NP_476466 978 peroxisome assembly factor 2

Identical Sequences to LMP012894 proteins

Reference Database Accession Length Protein Name
GI:16923976 DBBJ BAA09824.1 978 peroxisome assembly factor-2 [Rattus norvegicus]
GI:16923976 GenBank EDM18853.1 978 rCG43513 [Rattus norvegicus]
GI:16923976 PRF - 978 peroxisome assembly factor 2 [Rattus norvegicus]
GI:16923976 SwissProt P54777.1 978 RecName: Full=Peroxisome assembly factor 2; Short=PAF-2; AltName: Full=Peroxin-6; AltName: Full=Peroxisomal biogenesis factor 6; AltName: Full=Peroxisomal-type ATPase 1 [Rattus norvegicus]

Related Sequences to LMP012894 proteins

Reference Database Accession Length Protein Name
GI:16923976 GenBank EDM18853.1 978 rCG43513 [Rattus norvegicus]
GI:16923976 PRF - 978 peroxisome assembly factor 2 [Rattus norvegicus]
GI:16923976 SwissProt P54777.1 978 RecName: Full=Peroxisome assembly factor 2; Short=PAF-2; AltName: Full=Peroxin-6; AltName: Full=Peroxisomal biogenesis factor 6; AltName: Full=Peroxisomal-type ATPase 1 [Rattus norvegicus]