Gene/Proteome Database (LMPD)

LMPD ID
LMP012902
Gene ID
117554
Species
Rattus norvegicus (Rat)
Gene Name
pancreatic lipase-related protein 2
Gene Symbol
Pnliprp2
Alternate Names
pancreatic lipase-related protein 2; PL-RP2; galactolipase; secretory glycoprotein GP-3;
Chromosome
1
Map Location
1q55
EC Number
3.1.1.26
Summary
major digestive lipase of pancreas [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pnliprp2

Proteins

pancreatic lipase-related protein 2 precursor
Refseq ID NP_476554
Protein GI 17105374
UniProt ID P54318
mRNA ID NM_057206
Length 482
MPRGVSGNLFPSVQMLLCWIVSLLLATVGGKEVCYGHLGCFSNDKPWAGMLQRPLKIFPWSPEDIDTRFLLYTNENPNNYQKISATEPDTIKFSNFQLDRKTRFIVHGFIDKGEDGWLLDMCKKMFQVEKVNCICVDWRRGSRTEYTQASYNTRVVGAEIAFLVQVLSTEMGYSPENVHLIGHSLGAHVVGEAGRRLEGHVGRITGLDPAEPCFQGLPEEVRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQKVGHLDFFPNGGKEMPGCQKNILSTIVDINGIWEGTQNFVACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQQNDCFPCPEEGCPKMGHYADQFEGKTATVEQTVYLNTGDSGNFTRWRYKVSVTLSGAKKLSGYILVALYGNNGNSKQYEIFKGSLKPEARHVRDIDVDINVGEIQKVKFLWNNKVINLFRPTLGASQITVQSGVDGKEYNFCSSDTVREDVLQSLYPC
sig_peptide: 1..30 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3160 peptide sequence: MPRGVSGNLFPSVQMLLCWIVSLLLATVGG mat_peptide: 31..482 product: pancreatic lipase-related protein 2 experiment: experimental evidence, no additional details recorded calculated_mol_wt: 50864 peptide sequence: KEVCYGHLGCFSNDKPWAGMLQRPLKIFPWSPEDIDTRFLLYTNENPNNYQKISATEPDTIKFSNFQLDRKTRFIVHGFIDKGEDGWLLDMCKKMFQVEKVNCICVDWRRGSRTEYTQASYNTRVVGAEIAFLVQVLSTEMGYSPENVHLIGHSLGAHVVGEAGRRLEGHVGRITGLDPAEPCFQGLPEEVRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQKVGHLDFFPNGGKEMPGCQKNILSTIVDINGIWEGTQNFVACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQQNDCFPCPEEGCPKMGHYADQFEGKTATVEQTVYLNTGDSGNFTRWRYKVSVTLSGAKKLSGYILVALYGNNGNSKQYEIFKGSLKPEARHVRDIDVDINVGEIQKVKFLWNNKVINLFRPTLGASQITVQSGVDGKEYNFCSSDTVREDVLQSLYPC

Gene Information

Entrez Gene ID
117554
Gene Name
pancreatic lipase-related protein 2
Gene Symbol
Pnliprp2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0042589 IDA:RGD C zymogen granule membrane
GO:0047372 ISS:UniProtKB F acylglycerol lipase activity
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0047714 IDA:RGD F galactolipase activity
GO:0016298 IDA:RGD F lipase activity
GO:0004620 IDA:RGD F phospholipase activity
GO:0004806 IDA:RGD F triglyceride lipase activity
GO:0019376 IDA:RGD P galactolipid catabolic process
GO:0009395 ISS:UniProtKB P phospholipid catabolic process
GO:0009791 IEP:RGD P post-embryonic development
GO:0032094 IEP:RGD P response to food
GO:0051384 IEP:RGD P response to glucocorticoid
GO:0033993 IEP:RGD P response to lipid
GO:0043434 IEP:RGD P response to peptide hormone

KEGG Pathway Links

KEGG Pathway ID Description
M00098 Acylglycerol degradation
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase-related protein 2
Protein Entry
LIPR2_RAT
UniProt ID
P54318
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Function Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Shows a preference for 1,2- didodecanoylphosphatidylethanolamine and 1,2- didodecanoylphosphatidylglycerol, and has low activity towards 1,2-didodecanoylphosphatidylcholine (in vitro)
Sequence Caution Sequence=AAA41250.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Secreted. Membrane.
Tissue Specificity Pancreatic secretory (zymogen) granule.

Identical and Related Proteins

Unique RefSeq proteins for LMP012902 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17105374 RefSeq NP_476554 482 pancreatic lipase-related protein 2 precursor

Identical Sequences to LMP012902 proteins

Reference Database Accession Length Protein Name
GI:17105374 GenBank AAA41250.1 482 lipase [Rattus norvegicus]
GI:17105374 GenBank EDL94542.1 482 pancreatic lipase-related protein 2 [Rattus norvegicus]

Related Sequences to LMP012902 proteins

Reference Database Accession Length Protein Name
GI:17105374 GenBank AAA41250.1 482 lipase [Rattus norvegicus]
GI:17105374 GenBank EDL94542.1 482 pancreatic lipase-related protein 2 [Rattus norvegicus]
GI:17105374 PRF - 482 pancreatic lipase [Rattus norvegicus]