Gene/Proteome Database (LMPD)

LMPD ID
LMP012905
Gene ID
140607
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Gene Symbol
Pip4k2c
Synonyms
Pip5k2c;
Alternate Names
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; PIP4KII-gamma; PI(5)P 4-kinase type II gamma; phosphatidylinositol-5-phosphate 4-kinase type-2 gamma; phosphatidylinositol 5-phosphate 4-kinase type II gamma; phosphatidylinositol-4-phosphate 5-kinase, type II, gamma;
Chromosome
7
Map Location
7q22
EC Number
2.7.1.149
Summary
may play a role in phosphatidylinositol bisphosphate synthesis in the endoplasmic reticulum; has similarity to phosphatidylinositol 5-phosphate 4-kinase IIalpha and IIbeta isoforms [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pip4k2c

Proteins

phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Refseq ID NP_536728
Protein GI 158534075
UniProt ID O88370
mRNA ID NM_080480
Length 421
MASSSVPPATAPAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFAIDDHDYLVSLTRSPPSETEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEGPVREEESEWDGDCNLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFISNIFA

Gene Information

Entrez Gene ID
140607
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Gene Symbol
Pip4k2c
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0016308 IDA:RGD F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016309 IEA:UniProtKB-EC F 1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 NAS:RGD P phosphatidylinositol biosynthetic process
GO:0046854 IDA:GOC P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Protein Entry
PI42C_RAT
UniProt ID
O88370
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Function May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum
Ptm Phosphorylated
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular Location Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis.
Tissue Specificity Widely expressed, with the most abundant expression in kidney

Identical and Related Proteins

Unique RefSeq proteins for LMP012905 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158534075 RefSeq NP_536728 421 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Identical Sequences to LMP012905 proteins

Reference Database Accession Length Protein Name
GI:158534075 GenBank EDM16487.1 421 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma [Rattus norvegicus]

Related Sequences to LMP012905 proteins

Reference Database Accession Length Protein Name
GI:158534075 GenBank ABK42325.1 421 phosphoinositide 5-phosphate 4-kinase type II-gamma [synthetic construct]
GI:158534075 GenBank EDM16487.1 421 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma [Rattus norvegicus]
GI:158534075 RefSeq NP_473438.1 421 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [Mus musculus]