Gene/Proteome Database (LMPD)

LMPD ID
LMP012906
Gene ID
140638
Species
Rattus norvegicus (Rat)
Gene Name
apolipoprotein A-V
Gene Symbol
Apoa5
Synonyms
apo-AV; apoA-V;
Alternate Names
apolipoprotein A-V; apolipoprotein A5; regeneration-associated protein 3;
Chromosome
8
Map Location
8q23
Summary
member of the apolipoprotein family; expression increases during liver regeneration [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Apoa5

Proteins

apolipoprotein A-V precursor
Refseq ID NP_542143
Protein GI 18034777
UniProt ID Q9QUH3
mRNA ID NM_080576
Length 367
MAAVITWALALLSVFATVQARKSFWEYFGQNSQGKGMMGQQQKLAQESLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRLEPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGGVDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSDEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLHDQGHSQNNPEGHSG
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2077 peptide sequence: MAAVITWALALLSVFATVQA mat_peptide: 21..367 product: Apolipoprotein A-V experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QUH3.1) calculated_mol_wt: 39368 peptide sequence: RKSFWEYFGQNSQGKGMMGQQQKLAQESLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRLEPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGGVDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSDEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLHDQGHSQNNPEGHSG sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2077 peptide sequence: MAAVITWALALLSVFATVQA mat_peptide: 21..367 product: Apolipoprotein A-V experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QUH3.1) calculated_mol_wt: 39368 peptide sequence: RKSFWEYFGQNSQGKGMMGQQQKLAQESLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRLEPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGGVDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSDEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLHDQGHSQNNPEGHSG
apolipoprotein A-V precursor
Refseq ID NP_001264193
Protein GI 471270246
UniProt ID Q9QUH3
mRNA ID NM_001277264
Length 367
Protein sequence is identical to GI:18034777 (mRNA isoform)
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2077 peptide sequence: MAAVITWALALLSVFATVQA mat_peptide: 21..367 product: Apolipoprotein A-V experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QUH3.1) calculated_mol_wt: 39368 peptide sequence: RKSFWEYFGQNSQGKGMMGQQQKLAQESLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRLEPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGGVDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSDEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLHDQGHSQNNPEGHSG

Gene Information

Entrez Gene ID
140638
Gene Name
apolipoprotein A-V
Gene Symbol
Apoa5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0005615 IDA:RGD C extracellular space
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0008201 IEA:Ensembl F heparin binding
GO:0060230 IEA:Ensembl F lipoprotein lipase activator activity
GO:0031210 IEA:Ensembl F phosphatidylcholine binding
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0006869 IMP:RGD P lipid transport
GO:0042157 IEA:InterPro P lipoprotein metabolic process
GO:0031100 IEP:RGD P organ regeneration
GO:0045723 IEA:Ensembl P positive regulation of fatty acid biosynthetic process
GO:0051006 IEA:Ensembl P positive regulation of lipoprotein lipase activity
GO:0010898 IEA:Ensembl P positive regulation of triglyceride catabolic process
GO:0010902 IEA:Ensembl P positive regulation of very-low-density lipoprotein particle remodeling
GO:0009725 IEP:RGD P response to hormone
GO:0042246 IEA:Ensembl P tissue regeneration
GO:0019433 IEA:Ensembl P triglyceride catabolic process
GO:0070328 IEA:Ensembl P triglyceride homeostasis
GO:0034370 IEA:Ensembl P triglyceride-rich lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953879 Chylomicron-mediated lipid transport
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953754 Lipid digestion, mobilization, and transport
5953836 Lipoprotein metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954333 PPARA activates gene expression
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-V
Protein Entry
APOA5_RAT
UniProt ID
Q9QUH3
Species
Rat

Comments

Comment Type Description
Function Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity)
Induction Induced in early phase of liver regeneration. Expression is maximally increased 6 hours after partial hepatectomy, both at the liver RNA level and at the plasma protein level
Ptm Phosphorylation sites are present in the extracellular medium
Similarity Belongs to the apolipoprotein A1/A4/E family
Subcellular Location Secreted.
Subunit Interacts with GPIHBP1
Tissue Specificity Liver

Identical and Related Proteins

Unique RefSeq proteins for LMP012906 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18034777 RefSeq NP_542143 367 apolipoprotein A-V precursor

Identical Sequences to LMP012906 proteins

Reference Database Accession Length Protein Name
GI:18034777 GenBank AAF25660.1 367 apolipoprotein A5 [Rattus norvegicus]
GI:471270246 GenBank AAF25660.1 367 apolipoprotein A5 [Rattus norvegicus]
GI:471270246 GenBank AAH89780.1 367 Apoa5 protein [Rattus norvegicus]
GI:18034777 GenBank AAH89780.1 367 Apoa5 protein [Rattus norvegicus]
GI:471270246 RefSeq NP_542143.1 367 apolipoprotein A-V precursor [Rattus norvegicus]
GI:18034777 RefSeq NP_001264193.1 367 apolipoprotein A-V precursor [Rattus norvegicus]
GI:18034777 SwissProt Q9QUH3.1 367 RecName: Full=Apolipoprotein A-V; Short=Apo-AV; Short=ApoA-V; AltName: Full=Apolipoprotein A5; AltName: Full=Regeneration-associated protein 3; Flags: Precursor [Rattus norvegicus]
GI:471270246 SwissProt Q9QUH3.1 367 RecName: Full=Apolipoprotein A-V; Short=Apo-AV; Short=ApoA-V; AltName: Full=Apolipoprotein A5; AltName: Full=Regeneration-associated protein 3; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012906 proteins

Reference Database Accession Length Protein Name
GI:471270246 GenBank AAF25660.1 367 apolipoprotein A5 [Rattus norvegicus]
GI:18034777 GenBank AAF25660.1 367 apolipoprotein A5 [Rattus norvegicus]
GI:471270246 GenBank AAH89780.1 367 Apoa5 protein [Rattus norvegicus]
GI:18034777 GenBank AAH89780.1 367 Apoa5 protein [Rattus norvegicus]
GI:471270246 RefSeq NP_542143.1 367 apolipoprotein A-V precursor [Rattus norvegicus]
GI:18034777 SwissProt Q9QUH3.1 367 RecName: Full=Apolipoprotein A-V; Short=Apo-AV; Short=ApoA-V; AltName: Full=Apolipoprotein A5; AltName: Full=Regeneration-associated protein 3; Flags: Precursor [Rattus norvegicus]
GI:471270246 SwissProt Q9QUH3.1 367 RecName: Full=Apolipoprotein A-V; Short=Apo-AV; Short=ApoA-V; AltName: Full=Apolipoprotein A5; AltName: Full=Regeneration-associated protein 3; Flags: Precursor [Rattus norvegicus]