Gene/Proteome Database (LMPD)

LMPD ID
LMP012908
Gene ID
140866
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase, alpha
Gene Symbol
Dgka
Synonyms
Dagk1;
Alternate Names
diacylglycerol kinase alpha; DGK-alpha; DAG kinase alpha; diglyceride kinase alpha; 80 kDa diacylglycerol kinase;
Chromosome
7
Map Location
7q11
EC Number
2.7.1.107
Summary
may mediate myelin formation and metabolism; expressed specifically in oligodendrocytes [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dgka

Proteins

diacylglycerol kinase alpha
Refseq ID NP_542965
Protein GI 18158459
UniProt ID P51556
mRNA ID NM_080787
Length 727
MAKDKGLISPEDFAQLQKYIDYSTKSVSDVLKVFEMNKYCQGDEIGYLGFEQFLKMYLEVEEVPHHLCWTLFWSFHSSQDLDEETESKANVICLSDVYCYFTLLEGGSPEDKLEFTFKLYDMDRNGILDSTEVEKIILQMMRVAEYLDWDVSELRPILQEMMKEMDRDGSGCVSLAEWVRAGATTVPLLVLLGIDMTMKDDGHHIWRPKRFSRPVYCNLCELSIGLGKQGLSCNLCKYIVHDHCAMKAQPCEVSTYAKSRKDIGVQPHVWVRGGCHSGRCDRCQKKIRTYHSLTGLHCVWCHLEIHDDCLQAVGPECDCGLLRDHILPPCSIYPRVLVSGQECKQKTTDVTSLCTPEAFRIEPVSNTHPLLVFINPKSGGKQGQSVLWKFQYILNPRQVFNLKDGPEPGLRFFKDVPQFRVLVCGGDGTVGWILETIDKANFPIVPPVAVLPLGTGNDLARCLRWGRGYEGENLRKILKDIEISKVVYLDRWLLEVIPQQNGEKSDPVPSQIINNYFSIGVDASIAHRFHLMREKYPEKFNSRMKNKLWYLEFATSESIFSTCKKLEESVTVEICGKLLDLSDLSLEGIAVLNIPSMHGGSNLWGDTKRPHGDTCGINQALGSVAKIITDPDILKTCVPDMSDKRLEVVGIEGVIEMGQIYTRLKSAGHRLAKCSEITFQTTKTLPMQVDGEPWMQAPCTIKITHKNQMPMLMGPAPSSSNFFGFWS

Gene Information

Entrez Gene ID
140866
Gene Name
diacylglycerol kinase, alpha
Gene Symbol
Dgka
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR029477 Diacylglycerol kinase type I, N-terminal
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, alpha
Protein Entry
DGKA_RAT
UniProt ID
P51556
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C (By similarity)
Function Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.
Similarity Belongs to the eukaryotic diacylglycerol kinase family
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers
Subunit Monomer
Tissue Specificity Lymphocytes and oligodendroglial cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP012908 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18158459 RefSeq NP_542965 727 diacylglycerol kinase alpha

Identical Sequences to LMP012908 proteins

Reference Database Accession Length Protein Name
GI:18158459 GenBank AAB24434.1 727 diacylglycerol kinase [Rattus sp.]
GI:18158459 PRF - 727 diacylglycerol kinase [Rattus norvegicus]
GI:18158459 SwissProt P51556.1 727 RecName: Full=Diacylglycerol kinase alpha; Short=DAG kinase alpha; AltName: Full=80 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase alpha; Short=DGK-alpha [Rattus norvegicus]

Related Sequences to LMP012908 proteins

Reference Database Accession Length Protein Name
GI:18158459 GenBank AAB24434.1 727 diacylglycerol kinase [Rattus sp.]
GI:18158459 PRF - 727 diacylglycerol kinase [Rattus norvegicus]
GI:18158459 SwissProt P51556.1 727 RecName: Full=Diacylglycerol kinase alpha; Short=DAG kinase alpha; AltName: Full=80 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase alpha; Short=DGK-alpha [Rattus norvegicus]