Gene/Proteome Database (LMPD)

LMPD ID
LMP012910
Gene ID
140910
Species
Rattus norvegicus (Rat)
Gene Name
methylsterol monooxygenase 1
Gene Symbol
Msmo1
Synonyms
Sc4mol;
Alternate Names
methylsterol monooxygenase 1; RANP-1; neuropep 1; neurorep 1; C-4 methylsterol oxidase;
Chromosome
16
Map Location
16p13
EC Number
1.14.13.72
Summary
may be involved in the repair process of nerve tissues [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Msmo1

Proteins

methylsterol monooxygenase 1
Refseq ID NP_543162
Protein GI 18266684
UniProt ID O35532
mRNA ID NM_080886
Length 293
MAMNKSVGLFSSASLAVDYVDSLLPENPLQEPFKNAWVYMLDNYTKFQIATWGSLIVHETIYFLFSLPGFLFQFIPFMRKYKIQKDKPETFEGQWKCLKGILFNHFFIQLPLICGTYYFTEFFNIPYDWERMPRWYFTLARCLGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGIEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVTMRLLETIDVHSGYDIPLNPLNYIPFYTGARHHDFHHMNFIGNYASTFTWWDRIFGTDVQYHAYTEKMKKLGKKSE

Gene Information

Entrez Gene ID
140910
Gene Name
methylsterol monooxygenase 1
Gene Symbol
Msmo1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000254 IEA:UniProtKB-EC F C-4 methylsterol oxidase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0006633 IEA:InterPro P fatty acid biosynthetic process
GO:0016126 IEA:UniProtKB-KW P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
rno01100 Metabolic pathways
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR006694 Fatty_acid_hydroxylase

UniProt Annotations

Entry Information

Gene Name
methylsterol monooxygenase 1
Protein Entry
MSMO1_RAT
UniProt ID
O35532
Species
Rat

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest- 7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) = 3-beta-hydroxy-4- beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O.
Catalytic Activity 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha- cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O.
Catalytic Activity 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha- cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta- methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ;
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6.
Similarity Belongs to the sterol desaturase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012910 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18266684 RefSeq NP_543162 293 methylsterol monooxygenase 1

Identical Sequences to LMP012910 proteins

Reference Database Accession Length Protein Name
GI:18266684 EMBL CAR81352.1 293 unnamed protein product [Rattus norvegicus]
GI:18266684 EMBL CBX84828.1 293 unnamed protein product [Rattus norvegicus]
GI:18266684 GenBank AAH63155.1 293 Sterol-C4-methyl oxidase-like [Rattus norvegicus]
GI:18266684 GenBank EDL75983.1 293 sterol-C4-methyl oxidase-like, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012910 proteins

Reference Database Accession Length Protein Name
GI:18266684 EMBL CBX84828.1 293 unnamed protein product [Rattus norvegicus]
GI:18266684 GenBank EDL75983.1 293 sterol-C4-methyl oxidase-like, isoform CRA_a [Rattus norvegicus]
GI:18266684 SwissProt O35532.1 293 RecName: Full=Methylsterol monooxygenase 1; AltName: Full=C-4 methylsterol oxidase; AltName: Full=Neuropep 1; AltName: Full=RANP-1 [Rattus norvegicus]