Gene/Proteome Database (LMPD)

LMPD ID
LMP012914
Gene ID
156275
Species
Rattus norvegicus (Rat)
Gene Name
gamma-glutamyltransferase 7
Gene Symbol
Ggt7
Synonyms
Ggtl3;
Alternate Names
gamma-glutamyltransferase 7; GGT 7; glutathione hydrolase 7; gamma-glutamyltranspeptidase 7; gamma-glutamyltransferase-like 3;
Chromosome
3
Map Location
3q42
EC Number
2.3.2.2
Summary
a membrane-bound glycoenzyme [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ggt7

Proteins

gamma-glutamyltransferase 7
Refseq ID NP_569107
Protein GI 208973252
UniProt ID Q99MZ4
mRNA ID NM_130423
Length 662
MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDSFLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATGVTVALVMQIYFGDPQIFQQGAVVTDASCCTALGMEVLSKQGSSVDAAVAAALCLGIVAPHSSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREEALQRSWDTKPGLLVGVPGMVKGLYEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLAHALAEQLPPNASDRFLETFLPLGHPPLPGSLLRRPDLAEVLDILGISGPAAFYNGGNLTLEMVAEVQHAGGVMTEEDFSNYSALTEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTISESMDDMLSKVEAANFRGHISDSQAAPAPLLPVYELDGAPTAAQVLVMGPDDFIVAMVSSLNRPFGSGLLTPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNVLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIGVKDPRSLDATGASIL

Gene Information

Entrez Gene ID
156275
Gene Name
gamma-glutamyltransferase 7
Gene Symbol
Ggt7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003840 IEA:UniProtKB-EC F gamma-glutamyltransferase activity
GO:0036374 IEA:UniProtKB-EC F glutathione hydrolase activity
GO:0006750 IEA:UniProtKB-KW P glutathione biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00460 Cyanoamino acid metabolism
rno00460 Cyanoamino acid metabolism
ko00480 Glutathione metabolism
rno00480 Glutathione metabolism
rno01100 Metabolic pathways
ko00430 Taurine and hypotaurine metabolism
rno00430 Taurine and hypotaurine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000101 Gamma-glutamyltranspeptidase
IPR029055 Nucleophile aminohydrolases, N-terminal

UniProt Annotations

Entry Information

Gene Name
gamma-glutamyltransferase 7
Protein Entry
GGT7_RAT
UniProt ID
Q99MZ4
Species
Rat

Comments

Comment Type Description
Catalytic Activity A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Catalytic Activity Glutathione + H(2)O = L-cysteinylglycine + L- glutamate.
Caution The N-terminus was extended based on the genomic sequence, in analogy to ortholog sequences
Function Cleaves glutathione conjugates
Pathway Sulfur metabolism; glutathione metabolism.
Sequence Caution Sequence=AAK27971.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the gamma-glutamyltransferase family
Subcellular Location Membrane ; Single-pass type II membrane protein .
Subunit Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Interacts with FAM57A (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012914 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
208973252 RefSeq NP_569107 662 gamma-glutamyltransferase 7

Identical Sequences to LMP012914 proteins

Reference Database Accession Length Protein Name
GI:208973252 GenBank EDL85916.1 662 gamma-glutamyltransferase-like 3, isoform CRA_b [Rattus norvegicus]
GI:208973252 SwissProt Q99MZ4.2 662 RecName: Full=Gamma-glutamyltransferase 7; Short=GGT 7; AltName: Full=Gamma-glutamyltransferase-like 3; AltName: Full=Gamma-glutamyltranspeptidase 7; AltName: Full=Glutathione hydrolase 7; Contains: RecName: Full=Gamma-glutamyltransferase 7 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 7 light chain; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012914 proteins

Reference Database Accession Length Protein Name
GI:208973252 GenBank EDL85916.1 662 gamma-glutamyltransferase-like 3, isoform CRA_b [Rattus norvegicus]
GI:208973252 RefSeq XP_008760522.1 667 PREDICTED: gamma-glutamyltransferase 7 isoform X1 [Rattus norvegicus]
GI:208973252 SwissProt Q99MZ4.2 662 RecName: Full=Gamma-glutamyltransferase 7; Short=GGT 7; AltName: Full=Gamma-glutamyltransferase-like 3; AltName: Full=Gamma-glutamyltranspeptidase 7; AltName: Full=Glutathione hydrolase 7; Contains: RecName: Full=Gamma-glutamyltransferase 7 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 7 light chain; Flags: Precursor [Rattus norvegicus]