Gene/Proteome Database (LMPD)

LMPD ID
LMP012915
Gene ID
157074
Species
Rattus norvegicus (Rat)
Gene Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Gene Symbol
Sdha
Alternate Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; fp; flavoprotein subunit of complex II;
Chromosome
1
Map Location
1p11
EC Number
1.3.5.1
Summary
subunit of the mitochondrial succinate hehydrogenase that is involved in the oxidation of succinate; mutation of human homolog is associated with Leigh syndrome [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sdha

Proteins

succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor
Refseq ID NP_569112
Protein GI 18426858
UniProt ID Q920L2
mRNA ID NM_130428
Length 656
MAGVGAVSRLLRGRRLALAGATRGFHFSVGESKKASAKVSDAISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGRIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTIIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPPIKANAGEESVMNLDKLRFADGSVRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKVSQLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIEGQQKKPFAEHWRKHTLSYVDTKTGKVTLDYRPVIDKTLNEADCATVPPAIRSY
transit_peptide: 1..35 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q920L2.1) calculated_mol_wt: 3628 peptide sequence: MAGVGAVSRLLRGRRLALAGATRGFHFSVGESKKA mat_peptide: 36..656 product: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q920L2.1) calculated_mol_wt: 68005 peptide sequence: SAKVSDAISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGRIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTIIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPPIKANAGEESVMNLDKLRFADGSVRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKVSQLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIEGQQKKPFAEHWRKHTLSYVDTKTGKVTLDYRPVIDKTLNEADCATVPPAIRSY

Gene Information

Entrez Gene ID
157074
Gene Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Gene Symbol
Sdha
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0005749 ISS:UniProtKB C mitochondrial respiratory chain complex II
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0008177 IMP:RGD F succinate dehydrogenase (ubiquinone) activity
GO:0007399 IEA:Ensembl P nervous system development
GO:0022904 ISS:UniProtKB P respiratory electron transport chain
GO:0006105 ISS:UniProtKB P succinate metabolic process
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko00020 Citrate cycle (TCA cycle)
rno00020 Citrate cycle (TCA cycle)
M00009 Citrate cycle (TCA cycle, Krebs cycle)
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
ko05016 Huntington's disease
rno05016 Huntington's disease
rno01100 Metabolic pathways
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko00190 Oxidative phosphorylation
rno00190 Oxidative phosphorylation
rno05012 Parkinson's disease
M00148 Succinate dehydrogenase (ubiquinone)

REACTOME Pathway Links

REACTOME Pathway ID Description
5953285 Citric acid cycle (TCA cycle)
5953250 Metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5953747 Respiratory electron transport
5953748 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR003953 FAD binding domain
IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
IPR011281 Succinate dehydrogenase, flavoprotein subunit
IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

UniProt Annotations

Entry Information

Gene Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Protein Entry
SDHA_RAT
UniProt ID
Q920L2
Species
Rat

Comments

Comment Type Description
Catalytic Activity Succinate + a quinone = fumarate + a quinol.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Ptm Deacetylated by SIRT3
Ptm Phosphorylation at Tyr-207 is important for efficient electron transfer in complex II and the prevention of ROS generation
Similarity Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
Subcellular Location Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
Subunit Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012915 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18426858 RefSeq NP_569112 656 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

Identical Sequences to LMP012915 proteins

Reference Database Accession Length Protein Name
GI:18426858 DBBJ BAB69818.1 656 flavoprotein subunit of succinate-ubiquinone reductase [Rattus norvegicus]
GI:18426858 GenBank EDL87684.1 656 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Rattus norvegicus]
GI:18426858 SwissProt Q920L2.1 656 RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; AltName: Full=Flavoprotein subunit of complex II; Short=Fp; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012915 proteins

Reference Database Accession Length Protein Name
GI:18426858 DBBJ BAB69818.1 656 flavoprotein subunit of succinate-ubiquinone reductase [Rattus norvegicus]
GI:18426858 GenBank EDL87684.1 656 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Rattus norvegicus]
GI:18426858 SwissProt Q920L2.1 656 RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; AltName: Full=Flavoprotein subunit of complex II; Short=Fp; Flags: Precursor [Rattus norvegicus]