Gene/Proteome Database (LMPD)

LMPD ID
LMP012916
Gene ID
170465
Species
Rattus norvegicus (Rat)
Gene Name
acetyl-CoA acyltransferase 2
Gene Symbol
Acaa2
Alternate Names
3-ketoacyl-CoA thiolase, mitochondrial; beta-ketothiolase; mitochondrial 3-oxoacyl-CoA thiolase; acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase);
Chromosome
18
Map Location
18q12.3
EC Number
2.3.1.16
Summary
mitochondrial matrix protein with acetyl-Coenzyme A acyltransferase 2 activity [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acaa2

Proteins

3-ketoacyl-CoA thiolase, mitochondrial
Refseq ID NP_569117
Protein GI 18426866
UniProt ID P13437
mRNA ID NM_130433
Length 397
MALLRGVFIVAAKRTPFGAYGGLLKDFTATDLTEFAARAALSAGKVPPETIDSVIVGNVMQSSSDAAYLARHVGLRVGVPTETGALTLNRLCGSGFQSIVSGCQEICSKDAEVVLCGGTESMSQSPYSVRNVRFGTKFGLDLKLEDTLWAGLTDQHVKLPMGMTAENLAAKYNISREDCDRYALQSQQRWKAANEAGYFNEEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQNLPPVFKKEGTVTAGNASGMSDGAGVVIIASEDAVKKHNFTPLARVVGYFVSGCDPAIMGIGPVPAITGALKKAGLSLKDMDLIDVNEAFAPQFLAVQKSLDLDPSKTNVSGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGISLIIQNTA
transit_peptide: 1..16 experiment: experimental evidence, no additional details recorded note: Mitochondrion, not cleaved; propagated from UniProtKB/Swiss-Prot (P13437.1) calculated_mol_wt: 1743 peptide sequence: MALLRGVFIVAAKRTP

Gene Information

Entrez Gene ID
170465
Gene Name
acetyl-CoA acyltransferase 2
Gene Symbol
Acaa2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IDA:RGD C mitochondrial matrix
GO:0005739 IDA:RGD C mitochondrion
GO:0003988 IDA:RGD F acetyl-CoA C-acyltransferase activity
GO:0006084 IDA:RGD P acetyl-CoA metabolic process
GO:0006635 IDA:RGD P fatty acid beta-oxidation
GO:1901029 ISS:UniProtKB P negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
M00087 beta-Oxidation
M00085 Fatty acid biosynthesis, elongation, mitochondria
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko00062 Fatty acid elongation
rno00062 Fatty acid elongation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR020617 Thiolase, C-terminal
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR020616 Thiolase, N-terminal

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acyltransferase 2
Protein Entry
THIM_RAT
UniProt ID
P13437
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Function Abolishes BNIP3-mediated apoptosis and mitochondrial damage
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the thiolase family
Subcellular Location Mitochondrion . Note=Colocalizes with BNIP3 in the mitochondria
Subunit Homotetramer. Interacts with BNIP3 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012916 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18426866 RefSeq NP_569117 397 3-ketoacyl-CoA thiolase, mitochondrial

Identical Sequences to LMP012916 proteins

Reference Database Accession Length Protein Name
GI:18426866 EMBL CAA28952.1 397 unnamed protein product [Rattus norvegicus]
GI:18426866 SwissProt P13437.1 397 RecName: Full=3-ketoacyl-CoA thiolase, mitochondrial; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Beta-ketothiolase; AltName: Full=Mitochondrial 3-oxoacyl-CoA thiolase [Rattus norvegicus]

Related Sequences to LMP012916 proteins

Reference Database Accession Length Protein Name
GI:18426866 EMBL CAA28952.1 397 unnamed protein product [Rattus norvegicus]
GI:18426866 GenBank EDL82880.1 397 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_f [Rattus norvegicus]
GI:18426866 SwissProt P13437.1 397 RecName: Full=3-ketoacyl-CoA thiolase, mitochondrial; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Beta-ketothiolase; AltName: Full=Mitochondrial 3-oxoacyl-CoA thiolase [Rattus norvegicus]