Gene/Proteome Database (LMPD)

LMPD ID
LMP012918
Gene ID
170570
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA thioesterase 12
Gene Symbol
Acot12
Synonyms
Cach; rACH;
Alternate Names
acyl-coenzyme A thioesterase 12; CACH-1; rCACH-1; cytosolic acetyl-CoA hydrolase; acyl-CoA thioester hydrolase 12; cytoplasmic acetyl-CoA hydrolase 1;
Chromosome
2
Map Location
2q12
EC Number
3.1.2.1
Summary
acetyl-CoA hydrolase found in cytoplasm [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acot12

Proteins

acyl-coenzyme A thioesterase 12
Refseq ID NP_570103
Protein GI 18543355
UniProt ID Q99NB7
mRNA ID NM_130747
Length 556
MEPTVAPGEVLMSQAIQPAHADSRGELSAGQLLKWMDTTACLAAEKHAGISCVTASMDDILFEDTARIGQIVTIRAKVTRAFSTSMEISIKVRVQDKFTGIQKLLCVAFSTFVVKPLGKEKVHLKPVLLQTEQEQVEHRLASERRKVRLQHENTFSNIMKESNWLRDPVCNEEEGTATTMATSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCHGHPFLKSVDMFKFRGPSTVGDRLVFNAIVNNTFQNSVEVGVRVEAFDCREWAEGQGRHINSAFLIYNAVDDQEELITFPRIQPISKDDFRRYQGAIARRRIRLGRKYVISHKKEVPLGTQWDISKKGSISNTNVEALKNLASKSGWEITTTLEKIKIYTLEEQDAISVKVEKQVGSPARVAYHLLSDFTKRPLWDPHYISCEVIDQVSEDDQIYYITCSVVNGDKPKDFVVLVSQRKPLKDDNTYIVALMSVVLPSVPPSPQYIRSQVICAGFLIQPVDSSSCTVAYLNQMSDSILPYFAGNIGGWSKSIEEAAASCIKFIENATHDGLKSVL

Gene Information

Entrez Gene ID
170570
Gene Name
acyl-CoA thioesterase 12
Gene Symbol
Acot12
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:HGNC C cytosol
GO:0005524 ISS:BHF-UCL F ATP binding
GO:0003986 IDA:HGNC F acetyl-CoA hydrolase activity
GO:0052689 IEA:UniProtKB-KW F carboxylic ester hydrolase activity
GO:0008289 IEA:InterPro F lipid binding
GO:0006637 IDA:HGNC P acyl-CoA metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0006090 IEA:UniProtKB-UniPathway P pyruvate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029069 HotDog domain
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom
IPR006683 Thioesterase superfamily

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioesterase 12
Protein Entry
ACO12_RAT
UniProt ID
Q99NB7
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O = CoA + acetate.
Enzyme Regulation Allosterically regulated by ATP (activator) and ADP (inhibitor).
Function Hydrolyzes acetyl-CoA to acetate and CoA.
Induction By 2-(p-chlorophenoxy)isobutyric acid (CPIB).
Pathway Carbohydrate metabolism; pyruvate metabolism.
Similarity Contains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
Similarity Contains 2 acyl coenzyme A hydrolase domains
Subcellular Location Cytoplasm.
Subunit Active homodimer or homotetramer at room temperature and inactive monomer at low temperature.

Identical and Related Proteins

Unique RefSeq proteins for LMP012918 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18543355 RefSeq NP_570103 556 acyl-coenzyme A thioesterase 12

Identical Sequences to LMP012918 proteins

Reference Database Accession Length Protein Name
GI:18543355 DBBJ BAB39852.1 556 cytoplasmic acetyl-CoA hydrolase [Rattus norvegicus]
GI:18543355 SwissProt Q99NB7.1 556 RecName: Full=Acyl-coenzyme A thioesterase 12; Short=Acyl-CoA thioesterase 12; AltName: Full=Acyl-CoA thioester hydrolase 12; AltName: Full=Cytoplasmic acetyl-CoA hydrolase 1; Short=CACH-1; Short=rACH; Short=rCACH-1 [Rattus norvegicus]

Related Sequences to LMP012918 proteins

Reference Database Accession Length Protein Name
GI:18543355 DBBJ BAB39852.1 556 cytoplasmic acetyl-CoA hydrolase [Rattus norvegicus]
GI:18543355 GenBank EDM10006.1 556 acyl-CoA thioesterase 12 [Rattus norvegicus]
GI:18543355 SwissProt Q99NB7.1 556 RecName: Full=Acyl-coenzyme A thioesterase 12; Short=Acyl-CoA thioesterase 12; AltName: Full=Acyl-CoA thioester hydrolase 12; AltName: Full=Cytoplasmic acetyl-CoA hydrolase 1; Short=CACH-1; Short=rACH; Short=rCACH-1 [Rattus norvegicus]