Gene/Proteome Database (LMPD)

LMPD ID
LMP012920
Gene ID
170635
Species
Rattus norvegicus (Rat)
Gene Name
dehydrogenase/reductase (SDR family) member 9
Gene Symbol
Dhrs9
Synonyms
Rdhl;
Alternate Names
dehydrogenase/reductase SDR family member 9; 3alpha-HSD; 3-alpha-HSD; retinol dehydrogenase homolog; 3-alpha hydroxysteroid dehydrogenase; short-chain dehydrogenase/reductase retSDR8;
Chromosome
3
Map Location
3q21
EC Number
1.1.-.-
Summary
catalyzes the conversion of retinol to retinal in retinoic acid biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dhrs9

Proteins

dehydrogenase/reductase SDR family member 9 precursor
Refseq ID NP_570832
Protein GI 18677749
UniProt ID Q8VD48
mRNA ID NM_130819
Length 319
MLLWVLALLFLCAFLWNYKGQLKIADIADKYIFITGCDSGFGNLAARTFDRKGFRVIAACLTESGSEALKAKTSERLHTVLLDVTNPENVKETAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTGLADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSSTSSVNLDLSLVVECMDHALTSLFPKTRYTAGKDAKTFWIPLSHMPAALQDFLLLKEKVELANPQAV
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2415 peptide sequence: MLLWVLALLFLCAFLWNYKG mat_peptide: 21..319 product: Dehydrogenase/reductase SDR family member 9 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8VD48.1) calculated_mol_wt: 32817 peptide sequence: QLKIADIADKYIFITGCDSGFGNLAARTFDRKGFRVIAACLTESGSEALKAKTSERLHTVLLDVTNPENVKETAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTGLADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSSTSSVNLDLSLVVECMDHALTSLFPKTRYTAGKDAKTFWIPLSHMPAALQDFLLLKEKVELANPQAV

Gene Information

Entrez Gene ID
170635
Gene Name
dehydrogenase/reductase (SDR family) member 9
Gene Symbol
Dhrs9
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 ISS:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0004022 ISS:UniProtKB F alcohol dehydrogenase (NAD) activity
GO:0004745 ISS:UniProtKB F retinol dehydrogenase activity
GO:0047035 ISS:UniProtKB F testosterone dehydrogenase (NAD+) activity
GO:0042904 ISS:UniProtKB P 9-cis-retinoic acid biosynthetic process
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0042448 IEA:Ensembl P progesterone metabolic process
GO:0002138 IEP:RGD P retinoic acid biosynthetic process
GO:0042573 NAS:RGD P retinoic acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00830 Retinol metabolism
rno00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
dehydrogenase/reductase (SDR family) member 9
Protein Entry
DHRS9_RAT
UniProt ID
Q8VD48
Species
Rat

Comments

Comment Type Description
Function 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH (By similarity)
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Cytoplasm . Microsome membrane {ECO:0000250}. Endoplasmic reticulum membrane . Note=Associated with microsomal membranes
Subunit Homotetramer
Tissue Specificity Highly expressed in epithelium of estrus uterus

Identical and Related Proteins

Unique RefSeq proteins for LMP012920 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18677749 RefSeq NP_570832 319 dehydrogenase/reductase SDR family member 9 precursor

Identical Sequences to LMP012920 proteins

Reference Database Accession Length Protein Name
GI:18677749 GenBank AAL73225.1 319 retinol dehydrogenase [Rattus norvegicus]
GI:18677749 SwissProt Q8VD48.1 319 RecName: Full=Dehydrogenase/reductase SDR family member 9; AltName: Full=3-alpha hydroxysteroid dehydrogenase; Short=3-alpha-HSD; AltName: Full=Short-chain dehydrogenase/reductase retSDR8; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012920 proteins

Reference Database Accession Length Protein Name
GI:18677749 GenBank AAL73225.1 319 retinol dehydrogenase [Rattus norvegicus]
GI:18677749 GenBank AAX33670.1 319 epithelial retinol dehydrogenase [Mus musculus]
GI:18677749 SwissProt Q8VD48.1 319 RecName: Full=Dehydrogenase/reductase SDR family member 9; AltName: Full=3-alpha hydroxysteroid dehydrogenase; Short=3-alpha-HSD; AltName: Full=Short-chain dehydrogenase/reductase retSDR8; Flags: Precursor [Rattus norvegicus]