Gene/Proteome Database (LMPD)

LMPD ID
LMP012927
Gene ID
170907
Species
Rattus norvegicus (Rat)
Gene Name
serine incorporator 5
Gene Symbol
Serinc5
Synonyms
Tpo1;
Alternate Names
serine incorporator 5; developmentally regulated protein TPO1;
Chromosome
2
Map Location
2q12
Summary
contains cysteine-rich, zinc-finger-like motifs; may play a role in myelin biogenesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Serinc5

Proteins

serine incorporator 5
Refseq ID NP_596886
Protein GI 19173752
UniProt ID Q63175
mRNA ID NM_133395
Length 460
MSARCCAGQLACCCGSAGCALCCGCCPKFRQSRSTRFMYLFYFTLVIIPCCVMMSPSVMKQMTEHIPFFEDFCKGIKAGDTCENLVGYSAVYRVCFGMACFFFVFCVLTFKVNNSKSCRASIHNGFWFFKLLLLGAMCSGAFFIPDQETFLNVWRYVGAVGSFFFICIQLLLIVEFAHKWNKNWTAGTVRNKLWYASLSLALIMYSIAVGGLALMAVFYTQWDDCMDNKILLGVHGGLCVLISLAAISPCVQNRQPHSGLLQPGLISCYVTYLTFSALTSKPEKVVKDEHGKNVTICVPDFGQDFRRDESMVTWLGTLLLVVCISYSCLTSTTRSSSDALQRRYGAPELEVARCCFCFGPDGEDTEEQQNVKEGPRVIYDEKKGTVYSYSYFHFVLLLASLYVMMTLTSWFHYENATIETFFVGSWSIFWVKMASCWMCVLLYLWTLVAPLCCPSRQFSV

Gene Information

Entrez Gene ID
170907
Gene Name
serine incorporator 5
Gene Symbol
Serinc5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 ISS:HGNC C plasma membrane
GO:0015194 ISS:HGNC F L-serine transmembrane transporter activity
GO:0015825 ISS:HGNC P L-serine transport
GO:0042552 IEP:RGD P myelination
GO:0006658 IDA:HGNC P phosphatidylserine metabolic process
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0051347 IDA:HGNC P positive regulation of transferase activity
GO:0006665 ISS:HGNC P sphingolipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029555 Serinc5
IPR005016 Serine incorporator/TMS membrane protein

UniProt Annotations

Entry Information

Gene Name
serine incorporator 5
Protein Entry
SERC5_RAT
UniProt ID
Q63175
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q63175-1; Sequence=Displayed; Name=2; IsoId=Q63175-2; Sequence=VSP_033056;
Developmental Stage First detected in significant amounts at postnatal day 2 (P2) and increases about twofold to a peak value at P17-P20 and declines significantly thereafter
Function Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes. {ECO:0000269|PubMed:16120614, ECO:0000269|PubMed:9326262}.
Induction Up-regulated during the differentiation of oligodendrocyte lineage cells and during brain development at the time of myelination. Down-regulated in the hippocampal CA fields and dentate gyrus by seizures. {ECO:0000269|PubMed:16120614, ECO:0000269|PubMed:9326262}.
Similarity Belongs to the TDE1 family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Tissue Specificity Brain. Expressed at high levels in the white matter and the oligodendroglial cells of the brain. Expressed at low levels in the liver. {ECO:0000269|PubMed:16120614, ECO:0000269|PubMed:9326262}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012927 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19173752 RefSeq NP_596886 460 serine incorporator 5

Identical Sequences to LMP012927 proteins

Reference Database Accession Length Protein Name
GI:19173752 GenBank AAE44527.1 460 Sequence 5 from patent US 6080841
GI:19173752 GenBank AAZ80297.1 460 serine incorporator 5 [Rattus norvegicus]
GI:19173752 pat US 460 Sequence 5 from patent US 5776732
GI:19173752 SwissProt Q63175.1 460 RecName: Full=Serine incorporator 5; AltName: Full=Developmentally regulated protein TPO1 [Rattus norvegicus]

Related Sequences to LMP012927 proteins

Reference Database Accession Length Protein Name
GI:19173752 GenBank AAA41097.1 460 developmentally regulated protein [Rattus norvegicus]
GI:19173752 GenBank AAZ80297.1 460 serine incorporator 5 [Rattus norvegicus]
GI:19173752 SwissProt Q63175.1 460 RecName: Full=Serine incorporator 5; AltName: Full=Developmentally regulated protein TPO1 [Rattus norvegicus]