Gene/Proteome Database (LMPD)

LMPD ID
LMP012941
Gene ID
171178
Species
Rattus norvegicus (Rat)
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol
Adh7
Alternate Names
alcohol dehydrogenase class 4 mu/sigma chain; alcohol dehydrogenase class IV mu/sigma chain; class IV alcohol dehydrogenase, mu or sigma subunit;
Chromosome
2
Map Location
2q44
EC Number
1.1.1.1

Proteins

alcohol dehydrogenase class 4 mu/sigma chain
Refseq ID NP_599156
Protein GI 19705435
UniProt ID P41682
mRNA ID NM_134329
Length 374
MDTAGKVIKCKAAVLWGTNQPFSIEDIEVAPPKAKEVRVKILATGICGTDDHVIKGTMVSKFPVIVGHEAVGIVESVGEEVTTVRPGDKVIPLFLPQCRECNPCRNPEENLCIRSDLTGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKIDAEAPPEKACLIGCGFSTGYGAAVKTAKVSPGSTCAVFGLGGVGLSVVMGCKAAGASRIIGIDINKDKFQKALDVGATECINPRDFTKPISEVLSDMTGNTVQYTFEVIGRLETMVDALSSCHMNYGTSVVVGAPPSAKMLSYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLGQLITHTLPFHNISEGFELLYSGQSIRTVLTF

Gene Information

Entrez Gene ID
171178
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol
Adh7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004024 IEA:InterPro F alcohol dehydrogenase activity, zinc-dependent
GO:0004022 IDA:RGD F alcohol dehydrogenase (NAD) activity
GO:0035276 IDA:RGD F ethanol binding
GO:0051287 IDA:RGD F NAD binding
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0019841 IDA:RGD F retinol binding
GO:0004745 IEA:InterPro F retinol dehydrogenase activity
GO:0008270 IDA:RGD F zinc ion binding
GO:0006067 IDA:RGD P ethanol metabolic process
GO:0006069 IEA:InterPro P ethanol oxidation
GO:0001523 TAS:RGD P retinoid metabolic process
GO:0042572 IDA:RGD P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
ko00982 Drug metabolism - cytochrome P450
rno00982 Drug metabolism - cytochrome P450
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450
ko00830 Retinol metabolism
rno00830 Retinol metabolism
ko00350 Tyrosine metabolism
rno00350 Tyrosine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013149 Alcohol dehydrogenase, C-terminal
IPR028635 Alcohol dehydrogenase family, zinc-type, class-IV subfamily
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Protein Entry
ADH7_RAT
UniProt ID
P41682
Species
Rat

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 2 Zn(2+) ions per subunit. ;
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily
Subcellular Location Cytoplasm.
Subunit Homodimer.
Tissue Specificity Preferentially expressed in stomach.

Identical and Related Proteins

Unique RefSeq proteins for LMP012941 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19705435 RefSeq NP_599156 374 alcohol dehydrogenase class 4 mu/sigma chain

Identical Sequences to LMP012941 proteins

Reference Database Accession Length Protein Name
GI:19705435 EMBL CAA67297.1 374 alcohol dehydrogenase [Rattus norvegicus]

Related Sequences to LMP012941 proteins

Reference Database Accession Length Protein Name
GI:19705435 EMBL CAA67297.1 374 alcohol dehydrogenase [Rattus norvegicus]
GI:19705435 GenBank EDL82311.1 374 rCG28864 [Rattus norvegicus]
GI:19705435 RefSeq XP_008759715.1 422 PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Rattus norvegicus]
GI:19705435 SwissProt P41682.2 374 RecName: Full=Alcohol dehydrogenase class 4 mu/sigma chain; AltName: Full=Alcohol dehydrogenase class IV mu/sigma chain [Rattus norvegicus]