Gene/Proteome Database (LMPD)

LMPD ID
LMP012945
Gene ID
171410
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA synthetase bubblegum family member 1
Gene Symbol
Acsbg1
Synonyms
Lpd; Grlacs;
Alternate Names
long-chain-fatty-acid--CoA ligase ACSBG1; GR-LACS; lipidosin; gonadotropin-regulated long chain acyl CoA synthetase; gonadotropin-regulated long chain acyl-CoA synthetase;
Chromosome
8
Map Location
8q22-q24
EC Number
6.2.1.3
Summary
may play a role in fatty acid metabolism and biosynthesis of steroid hormone precursors [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acsbg1

Proteins

long-chain-fatty-acid--CoA ligase ACSBG1
Refseq ID NP_599216
Protein GI 19705503
UniProt ID Q924N5
mRNA ID NM_134389
Length 721
MPRSSEAGYCCLSRDSNMPDSRDDQQQGASMGTSPDNSQTSSLIDGRTLSKESPSHGLELSAPEKARAASLDASEEALWTTRADGRVRLRLEPFCTQLPYTVHQMFYEALDKYGNLSALGFKRKDKWERISYYQYYLIARKVAKGFLKLGLERAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAHDCRANVIVVDTQKQLEKILKIWKDLPHLKAVVIYQEPPPKKMANVYTMEELIELGQEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFADPDALKGTLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPSNDLKPFTSRLADYLVLARVRQALGFAKCQKNFYGAAPMTAETQRFFLGLNIRLYAGYGLSESTGPHFMSSPYNYRLYSSGRVVPGCRVKLVNQDADGIGEICLWGRTIFMGYLNMEDKTHEAIDSEGWLHTGDMGRLDDDGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISSAMLIGDQRKFLSMLLTLKCTLNPETSEPTDNLTEQAVEFCQRVGSKASTVSEIVGQKDEAVYQAIHEGIQRVNANAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKDIIDSFYQEQKQ

Gene Information

Entrez Gene ID
171410
Gene Name
acyl-CoA synthetase bubblegum family member 1
Gene Symbol
Acsbg1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 ISS:HGNC F long-chain fatty acid-CoA ligase activity
GO:0031957 ISS:HGNC F very long-chain fatty acid-CoA ligase activity
GO:0001676 ISS:HGNC P long-chain fatty acid metabolic process
GO:0001552 IEP:RGD P ovarian follicle atresia
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0000038 ISS:HGNC P very long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko00061 Fatty acid biosynthesis
rno00061 Fatty acid biosynthesis
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
M00086 beta-Oxidation, acyl-CoA synthesis

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase bubblegum family member 1
Protein Entry
ACBG1_RAT
UniProt ID
Q924N5
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids
Induction Down-regulated by gonadotropin
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily
Subcellular Location Cytoplasm . Cytoplasmic vesicle {ECO:0000250}. Microsome . Endoplasmic reticulum .
Tissue Specificity Present in testis, at a lower level in brain, and at a very low level in ovary. Not detected in other tissues. tested. Present in Leydig cells of the adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells (at protein level). {ECO:0000269|PubMed:11381125, ECO:0000269|PubMed:16469493}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012945 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19705503 RefSeq NP_599216 721 long-chain-fatty-acid--CoA ligase ACSBG1

Identical Sequences to LMP012945 proteins

Reference Database Accession Length Protein Name
GI:19705503 EMBL CBF65080.1 721 unnamed protein product [Rattus norvegicus]
GI:19705503 EMBL CBU89951.1 721 unnamed protein product [Rattus norvegicus]
GI:19705503 GenBank AGX56980.1 721 Sequence 14279 from patent US 8541208
GI:19705503 SwissProt Q924N5.1 721 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1; AltName: Full=Acyl-CoA synthetase bubblegum family member 1; AltName: Full=Gonadotropin-regulated long chain acyl CoA synthetase; Short=GR-LACS [Rattus norvegicus]

Related Sequences to LMP012945 proteins

Reference Database Accession Length Protein Name
GI:19705503 EMBL CBF65080.1 721 unnamed protein product [Rattus norvegicus]
GI:19705503 EMBL CBU89951.1 721 unnamed protein product [Rattus norvegicus]
GI:19705503 GenBank AGX56980.1 721 Sequence 14279 from patent US 8541208
GI:19705503 SwissProt Q924N5.1 721 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1; AltName: Full=Acyl-CoA synthetase bubblegum family member 1; AltName: Full=Gonadotropin-regulated long chain acyl CoA synthetase; Short=GR-LACS [Rattus norvegicus]