Gene/Proteome Database (LMPD)

LMPD ID
LMP012949
Gene ID
171516
Species
Rattus norvegicus (Rat)
Gene Name
aldo-keto reductase family 1, member C3
Gene Symbol
Akr1c3
Synonyms
Akr1c18;
Alternate Names
aldo-keto reductase family 1 member C18; HSD1; 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-hydroxysteroid dehydrogenase; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II);
Chromosome
17
Map Location
17q12.3
EC Number
1.1.-.-
Summary
catalyses the convariant of progesterone into 20 alpha-dihydroprogesterone (20 alpha-OHP); activity is regulated by prolactin [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Akr1c3

Proteins

aldo-keto reductase family 1 member C18
Refseq ID NP_612519
Protein GI 19924035
UniProt ID P51652
mRNA ID NM_138510
Length 323
MNSKIQKMELNDGHSIPVLGFGTYATEENLRKKSMESTKIAIDVGFRHIDCSHLYQNEEEIGQAIVSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGDELLPQDEHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKHRPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPILCTMAKKYKRTPALIALRYQLERGIVTLVKSFNEERIRENLQVFDFQLASDDMEILDNLDRNLRYFPANMFKAHPNFPFSDEY

Gene Information

Entrez Gene ID
171516
Gene Name
aldo-keto reductase family 1, member C3
Gene Symbol
Akr1c3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:MGI C cytosol
GO:0047006 IDA:MGI F 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO:0007567 IEA:Ensembl P parturition
GO:0006709 IEA:Ensembl P progesterone catabolic process
GO:0042448 IDA:MGI P progesterone metabolic process
GO:0050810 IDA:RGD P regulation of steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953493 Arachidonic acid metabolism
5953720 Bile acid and bile salt metabolism
5953253 Disease
5953382 Diseases associated with visual transduction
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954392 Retinoid metabolism and transport
5953381 Signal Transduction
5953930 Synthesis of bile acids and bile salts
5953933 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
5953929 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5953931 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5953492 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR001395 Aldo/keto reductase
IPR018170 Aldo/keto reductase, conserved site
IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain

UniProt Annotations

Entry Information

Gene Name
aldo-keto reductase family 1, member C3
Protein Entry
AKC1H_RAT
UniProt ID
P51652
Species
Rat

Comments

Comment Type Description
Catalytic Activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha-hydroxyprogesterone + NAD(P)H.
Developmental Stage Remains repressed throughout pregnancy and becomes highly and rapidly expressed before parturition.
Function Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP).
Induction Repressed by prolactin.
Ptm The N-terminus is blocked.
Similarity Belongs to the aldo/keto reductase family
Subcellular Location Cytoplasm.
Subunit Monomer.
Tissue Specificity Corpus luteum (large luteal cells).

Identical and Related Proteins

Unique RefSeq proteins for LMP012949 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19924035 RefSeq NP_612519 323 aldo-keto reductase family 1 member C18

Identical Sequences to LMP012949 proteins

Reference Database Accession Length Protein Name
GI:19924035 GenBank AAE40043.1 323 Sequence 2 from patent US 6001353
GI:19924035 GenBank AAI00249.1 323 Aldo-keto reductase family 1, member C18 [Rattus norvegicus]
GI:19924035 GenBank EDL78573.1 323 aldo-keto reductase family 1, member C18, isoform CRA_a [Rattus norvegicus]
GI:19924035 GenBank ACQ18780.1 323 Sequence 35 from patent US 7510851

Related Sequences to LMP012949 proteins

Reference Database Accession Length Protein Name
GI:19924035 DBBJ BAA03317.1 323 20-alpha-hydroxysteroid dehydrogenase [Rattus norvegicus]
GI:19924035 GenBank AAA40601.1 323 20-alpha-hydroxysteroid dehydrogenase [Rattus norvegicus]
GI:19924035 GenBank EDL78573.1 323 aldo-keto reductase family 1, member C18, isoform CRA_a [Rattus norvegicus]
GI:19924035 SwissProt P51652.1 323 RecName: Full=Aldo-keto reductase family 1 member C18; AltName: Full=20-alpha-hydroxysteroid dehydrogenase; Short=20-alpha-HSD; AltName: Full=HSD1 [Rattus norvegicus]