Gene/Proteome Database (LMPD)

LMPD ID
LMP012955
Gene ID
192223
Species
Rattus norvegicus (Rat)
Gene Name
opsin 4
Gene Symbol
Opn4
Alternate Names
melanopsin; opsin-4; opn4 {ECO:0000312|RGD:621701};
Chromosome
16
Map Location
16p15
Summary
visual pigment of phototransducing retinal ganglion cells involved in setting the circadian clock [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Opn4

Proteins

melanopsin
Refseq ID NP_620215
Protein GI 20302016
UniProt ID Q8R456
mRNA ID NM_138860
Length 474
MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPTTPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGETGCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRAAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPKTKRHLPSLDRRM

Gene Information

Entrez Gene ID
192223
Gene Name
opsin 4
Gene Symbol
Opn4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 TAS:UniProtKB C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005502 ISS:UniProtKB F 11-cis retinal binding
GO:0008020 IDA:RGD F G-protein coupled photoreceptor activity
GO:0007602 IDA:RGD P phototransduction
GO:0018298 IEA:UniProtKB-KW P protein-chromophore linkage
GO:0042752 ISS:UniProtKB P regulation of circadian rhythm
GO:0016056 IEA:Ensembl P rhodopsin mediated signaling pathway
GO:0048511 IEA:UniProtKB-KW P rhythmic process
GO:0007601 IEA:InterPro P visual perception

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954247 Opsins
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR001760 Opsin
IPR027430 Visual pigments (opsins) retinal binding site

UniProt Annotations

Entry Information

Gene Name
opsin 4
Protein Entry
OPN4_RAT
UniProt ID
Q8R456
Species
Rat

Comments

Comment Type Description
Function Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal
Similarity Belongs to the G-protein coupled receptor 1 family. Opsin subfamily
Subcellular Location Cell membrane ; Multi-pass membrane protein . Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells.
Tissue Specificity Eye; expressed in a photosensitive subset of retinal ganglion cells

Identical and Related Proteins

Unique RefSeq proteins for LMP012955 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20302016 RefSeq NP_620215 474 melanopsin

Identical Sequences to LMP012955 proteins

Reference Database Accession Length Protein Name
GI:20302016 GenBank AAN21183.1 474 Sequence 8 from patent US 6413731
GI:20302016 GenBank ABH66427.1 474 Sequence 8 from patent US 7029914
GI:20302016 GenBank EDL88867.1 474 opsin 4 (melanopsin), isoform CRA_b [Rattus norvegicus]
GI:20302016 SwissProt Q8R456.1 474 RecName: Full=Melanopsin; AltName: Full=Opsin-4 [Rattus norvegicus]

Related Sequences to LMP012955 proteins

Reference Database Accession Length Protein Name
GI:20302016 GenBank AAL61854.1 474 melanopsin [Rattus norvegicus]
GI:20302016 GenBank AAN21183.1 474 Sequence 8 from patent US 6413731
GI:20302016 GenBank EDL88867.1 474 opsin 4 (melanopsin), isoform CRA_b [Rattus norvegicus]
GI:20302016 SwissProt Q8R456.1 474 RecName: Full=Melanopsin; AltName: Full=Opsin-4 [Rattus norvegicus]