Gene/Proteome Database (LMPD)

LMPD ID
LMP012964
Gene ID
192272
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA thioesterase 2
Gene Symbol
Acot2
Synonyms
Mte1;
Alternate Names
acyl-coenzyme A thioesterase 2, mitochondrial; MTE-I; ARTISt/p43; acyl coenzyme A thioester hydrolase; mitochondrial acyl-CoA thioesterase 1; very-long-chain acyl-CoA thioesterase;
Chromosome
6
Map Location
6q31
Summary
hydrolase that is inducible by peroxisome proliferators; may have a role in lipid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acot2

Proteins

acyl-coenzyme A thioesterase 2, mitochondrial
Refseq ID NP_620262
Protein GI 48675862
UniProt ID Q6IMX8
mRNA ID NM_138907
Length 453
MVASSFAVLRASRLCQWGWKSWTQLSGPPPLSTGGRTTFARTNATLSLEPGSRSCWDEPLSITVRGLAPEQPVTLRAALRDEKGALFRAHARYRADAGGELDLARAPALGGSFTGLEPMGLIWAMEPERPLWRLVKRDVQKPYVVELEVLDGHEPDGGQRLAQAVHERHFMAPGVRRVPVRDGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTVCYKDETIPPVSLLRDKVKMTKDGLLDVVEALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIICYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVAQLDAWQQLQTFFHKQLSGKS
transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O55171.1) calculated_mol_wt: 4597 peptide sequence: MVASSFAVLRASRLCQWGWKSWTQLSGPPPLSTGGRTTFART mat_peptide: 43..453 product: Acyl-coenzyme A thioesterase 2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O55171.1) calculated_mol_wt: 45050 peptide sequence: NATLSLEPGSRSCWDEPLSITVRGLAPEQPVTLRAALRDEKGALFRAHARYRADAGGELDLARAPALGGSFTGLEPMGLIWAMEPERPLWRLVKRDVQKPYVVELEVLDGHEPDGGQRLAQAVHERHFMAPGVRRVPVRDGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTVCYKDETIPPVSLLRDKVKMTKDGLLDVVEALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIICYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVAQLDAWQQLQTFFHKQLSGKS

Gene Information

Entrez Gene ID
192272
Gene Name
acyl-CoA thioesterase 2
Gene Symbol
Acot2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016790 IEA:InterPro F thiolester hydrolase activity
GO:0006637 IEA:InterPro P acyl-CoA metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko00062 Fatty acid elongation
rno00062 Fatty acid elongation
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis

Domain Information

InterPro Annotations

Accession Description
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioesterase 2
Protein Entry
Q6IMX8_RAT
UniProt ID
Q6IMX8
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012964 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
48675862 RefSeq NP_620262 453 acyl-coenzyme A thioesterase 2, mitochondrial

Identical Sequences to LMP012964 proteins

Reference Database Accession Length Protein Name
GI:48675862 GenBank AAH72540.1 453 Acyl-CoA thioesterase 2 [Rattus norvegicus]
GI:48675862 GenBank EDL81468.1 453 rCG20653 [Rattus norvegicus]

Related Sequences to LMP012964 proteins

Reference Database Accession Length Protein Name
GI:48675862 EMBL CAA70513.1 453 mitochondrial very-long-chain acyl-CoA thioesterase [Rattus norvegicus]
GI:48675862 GenBank AAH72540.1 453 Acyl-CoA thioesterase 2 [Rattus norvegicus]
GI:48675862 GenBank EDL81468.1 453 rCG20653 [Rattus norvegicus]
GI:48675862 SwissProt O55171.1 453 RecName: Full=Acyl-coenzyme A thioesterase 2, mitochondrial; Short=Acyl-CoA thioesterase 2; AltName: Full=ARTISt/p43; AltName: Full=Acyl coenzyme A thioester hydrolase; AltName: Full=MTE-I; AltName: Full=Very-long-chain acyl-CoA thioesterase; Flags: Precursor [Rattus norvegicus]