Gene/Proteome Database (LMPD)

LMPD ID
LMP012967
Gene ID
246074
Species
Rattus norvegicus (Rat)
Gene Name
stearoyl-Coenzyme A desaturase 1
Gene Symbol
Scd1
Alternate Names
acyl-CoA desaturase 1; delta-9 desaturase 1; delta(9)-desaturase 1; fatty acid desaturase 1; stearoyl-CoA desaturase 1;
Chromosome
1
Map Location
1q54
EC Number
1.14.19.1
Summary
enzyme involved in the synthesis and regulation of unsaturated fatty acids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Scd1

Proteins

acyl-CoA desaturase 1
Refseq ID NP_631931
Protein GI 148747464
UniProt ID P07308
mRNA ID NM_139192
Length 358
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS

Gene Information

Entrez Gene ID
246074
Gene Name
stearoyl-Coenzyme A desaturase 1
Gene Symbol
Scd1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 TAS:RGD C integral component of endoplasmic reticulum membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IDA:RGD F stearoyl-CoA 9-desaturase activity
GO:0050873 IEA:Ensembl P brown fat cell differentiation
GO:0034435 IEA:Ensembl P cholesterol esterification
GO:0050830 IEA:Ensembl P defense response to Gram-positive bacterium
GO:0006633 TAS:RGD P fatty acid biosynthetic process
GO:0008610 IEP:RGD P lipid biosynthetic process
GO:0044130 IEA:Ensembl P negative regulation of growth of symbiont in host
GO:0050872 IEA:Ensembl P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5996 oleate biosynthesis II (animals and fungi)

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR015876 Fatty acid desaturase, type 1, core
IPR001522 Fatty acid desaturase, type 1, C-terminal

UniProt Annotations

Entry Information

Gene Name
stearoyl-Coenzyme A desaturase 1
Protein Entry
ACOD1_RAT
UniProt ID
P07308
Species
Rat

Comments

Comment Type Description
Catalytic Activity Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Induction This protein is the only inducible component of this fatty acyl-CoA desaturase system.
Miscellaneous Desaturase has a half-life of only 4 hours.
Similarity Belongs to the fatty acid desaturase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012967 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148747464 RefSeq NP_631931 358 acyl-CoA desaturase 1

Identical Sequences to LMP012967 proteins

Reference Database Accession Length Protein Name
GI:148747464 GenBank AAM34746.1 358 stearoyl-coenzyme A desaturase 1 [Rattus norvegicus]
GI:148747464 GenBank EDL94283.1 358 rCG57790, isoform CRA_a [Rattus norvegicus]
GI:148747464 RefSeq XP_006231495.1 358 PREDICTED: acyl-CoA desaturase 1 isoform X1 [Rattus norvegicus]
GI:148747464 SwissProt P07308.2 358 RecName: Full=Acyl-CoA desaturase 1; AltName: Full=Delta(9)-desaturase 1; Short=Delta-9 desaturase 1; AltName: Full=Fatty acid desaturase 1; AltName: Full=Stearoyl-CoA desaturase 1 [Rattus norvegicus]

Related Sequences to LMP012967 proteins

Reference Database Accession Length Protein Name
GI:148747464 GenBank AAM34745.1 358 stearoyl-coenzyme A desaturase 1 [Rattus norvegicus]
GI:148747464 GenBank AAM34746.1 358 stearoyl-coenzyme A desaturase 1 [Rattus norvegicus]
GI:148747464 GenBank EDL94283.1 358 rCG57790, isoform CRA_a [Rattus norvegicus]
GI:148747464 SwissProt P07308.2 358 RecName: Full=Acyl-CoA desaturase 1; AltName: Full=Delta(9)-desaturase 1; Short=Delta-9 desaturase 1; AltName: Full=Fatty acid desaturase 1; AltName: Full=Stearoyl-CoA desaturase 1 [Rattus norvegicus]