Gene/Proteome Database (LMPD)

LMPD ID
LMP012968
Gene ID
246115
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidic acid phosphatase type 2c
Gene Symbol
Ppap2c
Alternate Names
lipid phosphate phosphohydrolase 2; PAP2c; PAP-2c; PAP2-G; PAP2-gamma; phosphatidic acid phosphatase 2c; phosphatidate phosphohydrolase type 2c;
Chromosome
7
Map Location
7q11
EC Number
3.1.3.4
Summary
catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ppap2c

Proteins

lipid phosphate phosphohydrolase 2
Refseq ID NP_640345
Protein GI 21245102
UniProt ID Q8K593
mRNA ID NM_139252
Length 276
MERRWVFVLLDVLCVLVASLPFIILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVIITATVVLVSSGEAYLVYTDRLYSRSDFNNYVAAIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYVSDFFKSRPPQSCQENEESERKPSLSLTLTLGDRP

Gene Information

Entrez Gene ID
246115
Gene Name
phosphatidic acid phosphatase type 2c
Gene Symbol
Ppap2c
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008195 NAS:RGD F phosphatidate phosphatase activity
GO:0016311 NAS:GOC P dephosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism
M00089 Triacylglycerol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954266 Sphingolipid de novo biosynthesis
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR028674 Lipid phosphate phosphohydrolase 2
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
phosphatidic acid phosphatase type 2c
Protein Entry
LPP2_RAT
UniProt ID
Q8K593
Species
Rat

Comments

Comment Type Description
Catalytic Activity A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Function Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P) (By similarity)
Similarity Belongs to the PA-phosphatase related phosphoesterase family
Subcellular Location Membrane; Multi-pass membrane protein.
Subunit Homodimer
Tissue Specificity Expressed in the brain

Identical and Related Proteins

Unique RefSeq proteins for LMP012968 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21245102 RefSeq NP_640345 276 lipid phosphate phosphohydrolase 2

Identical Sequences to LMP012968 proteins

Reference Database Accession Length Protein Name
GI:21245102 GenBank AAH62088.1 276 Phosphatidic acid phosphatase type 2c [Rattus norvegicus]
GI:21245102 GenBank EDL89430.1 276 phosphatidic acid phosphatase type 2c, isoform CRA_c [Rattus norvegicus]
GI:21245102 GenBank EDL89431.1 276 phosphatidic acid phosphatase type 2c, isoform CRA_c [Rattus norvegicus]
GI:21245102 SwissProt Q8K593.1 276 RecName: Full=Lipid phosphate phosphohydrolase 2; AltName: Full=PAP2-gamma; Short=PAP2-G; AltName: Full=Phosphatidate phosphohydrolase type 2c; AltName: Full=Phosphatidic acid phosphatase 2c; Short=PAP-2c; Short=PAP2c [Rattus norvegicus]

Related Sequences to LMP012968 proteins

Reference Database Accession Length Protein Name
GI:21245102 GenBank AAM28632.1 276 lipid phosphate phosphohydrolase 2 [Rattus norvegicus]
GI:21245102 GenBank EDL89430.1 276 phosphatidic acid phosphatase type 2c, isoform CRA_c [Rattus norvegicus]
GI:21245102 GenBank EDL89431.1 276 phosphatidic acid phosphatase type 2c, isoform CRA_c [Rattus norvegicus]
GI:21245102 SwissProt Q8K593.1 276 RecName: Full=Lipid phosphate phosphohydrolase 2; AltName: Full=PAP2-gamma; Short=PAP2-G; AltName: Full=Phosphatidate phosphohydrolase type 2c; AltName: Full=Phosphatidic acid phosphatase 2c; Short=PAP-2c; Short=PAP2c [Rattus norvegicus]