Gene/Proteome Database (LMPD)

LMPD ID
LMP012970
Gene ID
246211
Species
Rattus norvegicus (Rat)
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Gene Symbol
Hsd3b7
Synonyms
Cca2;
Alternate Names
3 beta-hydroxysteroid dehydrogenase type 7; 3-beta-HSD VII; c(27) 3-beta-HSD; confluent 3Y1 cell-associated 2; hsd3b7 {ECO:0000312|RGD:628727}; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase;
Chromosome
1
Map Location
1q36
EC Number
1.1.1.-
Summary
protein that is expressed in under growth-arrest conditions [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hsd3b7

Proteins

3 beta-hydroxysteroid dehydrogenase type 7
Refseq ID NP_647545
Protein GI 21326449
UniProt ID O35048
mRNA ID NM_139329
Length 338
MADSAQVPALVYLVTGGCGFLGEHIVRMLLEWEPRLRELRVFDLHLSSWLEELKTGPVQVTAIQGDVTQAHEVAAAMAGSHVVIHTAGLVDVFGKASPETIHKVNVQGTQNVIDACVQTGTRLLVYTSSMEVVGPNVKGHPFYRGNEDTPYEAIHRHPYPCSKALAEQLVLEANGRKGLRFGGRLFRAIPASVEHGRVYVGNVAWMHILVARELEQRAALMGGQVYFCYDKSPYKSYEDFNMEFLSPCGLRLIGTHPLLPYWLLVLLTALNALLQWLLRPLVLYTPLLNPYTLAVANTTFTVSTNKAQRHFGYKPLFSWEESRARTIHWVQAMEGSAW

Gene Information

Entrez Gene ID
246211
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Gene Symbol
Hsd3b7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0003854 IEA:InterPro F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0047016 IDA:RGD F cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
GO:0008206 TAS:RGD P bile acid metabolic process
GO:0001558 IDA:RGD P regulation of cell growth
GO:0006694 IEA:UniProtKB-UniPathway P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00120 Primary bile acid biosynthesis
rno00120 Primary bile acid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Protein Entry
3BHS7_RAT
UniProt ID
O35048
Species
Rat

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = 3- oxo-Delta(5)-steroid + NADH.
Catalytic Activity Cholest-5-ene-3-beta,7-alpha-diol + NAD(+) = 7-alpha-hydroxycholest-4-en-3-one + NADH.
Function The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (By similarity)
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the 3-beta-HSD family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Tissue Specificity High levels in liver and lung, moderate levels in spleen, brain, heart, kidney, jejunum and testis. Up-regulated in 3Y1 cells upon growth arrest

Identical and Related Proteins

Unique RefSeq proteins for LMP012970 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21326449 RefSeq NP_647545 338 3 beta-hydroxysteroid dehydrogenase type 7

Identical Sequences to LMP012970 proteins

Reference Database Accession Length Protein Name
GI:21326449 DBBJ BAA22931.1 338 CCA2 protein [Rattus norvegicus]
GI:21326449 SwissProt O35048.1 338 RecName: Full=3 beta-hydroxysteroid dehydrogenase type 7; AltName: Full=3 beta-hydroxysteroid dehydrogenase type VII; Short=3-beta-HSD VII; AltName: Full=3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; Short=C(27) 3-beta-HSD; AltName: Full=Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; AltName: Full=Confluent 3Y1 cell-associated 2 [Rattus norvegicus]

Related Sequences to LMP012970 proteins

Reference Database Accession Length Protein Name
GI:21326449 DBBJ BAA22931.1 338 CCA2 protein [Rattus norvegicus]
GI:21326449 GenBank EDM17234.1 338 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7, isoform CRA_d [Rattus norvegicus]
GI:21326449 RefSeq XP_006230274.1 369 PREDICTED: 3 beta-hydroxysteroid dehydrogenase type 7 isoform X1 [Rattus norvegicus]
GI:21326449 SwissProt O35048.1 338 RecName: Full=3 beta-hydroxysteroid dehydrogenase type 7; AltName: Full=3 beta-hydroxysteroid dehydrogenase type VII; Short=3-beta-HSD VII; AltName: Full=3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; Short=C(27) 3-beta-HSD; AltName: Full=Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; AltName: Full=Confluent 3Y1 cell-associated 2 [Rattus norvegicus]