Gene/Proteome Database (LMPD)

LMPD ID
LMP012972
Gene ID
246246
Species
Rattus norvegicus (Rat)
Gene Name
patatin-like phospholipase domain containing 7
Gene Symbol
Pnpla7
Synonyms
Ntel; Ntel1; Nte-related;
Alternate Names
patatin-like phospholipase domain-containing protein 7; NTE-related esterase; liver NTE-related protein 1; neuropathy target esterase like 1;
Chromosome
3
Map Location
3p13
EC Number
3.1.1.-
Summary
esterase; hydrolyzes phenyl valerate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pnpla7

Proteins

patatin-like phospholipase domain-containing protein 7
Refseq ID NP_653339
Protein GI 189303567
UniProt ID Q5BK26
mRNA ID NM_144738
Length 1349
MQKEEDVCPEAGYCLGTALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSPRLSEFNSSDQRSVAVSGPLLKRSCSVPLPPIHGEIDELRQAQGSGSNTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSVVAETSAVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGTGHQLGFNTASSKWDLGNPPGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELEQMLESTAVRAQKQLILLHKEEGPAPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAKQWAEDMTSMVKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSECEPSMSQGPHSLTSPKQSQDSFPWLPNQDDQGPRLYRPS

Gene Information

Entrez Gene ID
246246
Gene Name
patatin-like phospholipase domain containing 7
Gene Symbol
Pnpla7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0052689 IMP:RGD F carboxylic ester hydrolase activity
GO:0006629 IEA:InterPro P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000595 Cyclic nucleotide-binding domain
IPR018490 Cyclic nucleotide-binding-like
IPR002641 Patatin/Phospholipase A2-related
IPR014710 RmlC-like jelly roll fold

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 7
Protein Entry
PLPL7_RAT
UniProt ID
Q5BK26
Species
Rat

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-27 is the initiator
Function Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy
Sequence Caution Sequence=AAH91230.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the NTE family
Similarity Contains 1 patatin domain
Similarity Contains 3 cyclic nucleotide-binding domains
Subcellular Location Membrane ; Single-pass membrane protein {ECO:0000305}. Nucleus membrane ; Single-pass membrane protein . Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein {ECO:0000305}. Microsome membrane ; Single-pass membrane protein . Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions
Tissue Specificity Expressed in the brain, liver, kidney, lung and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012972 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189303567 RefSeq NP_653339 1349 patatin-like phospholipase domain-containing protein 7

Identical Sequences to LMP012972 proteins

Reference Database Accession Length Protein Name
GI:189303567 GenBank EDL93647.1 1349 neuropathy target esterase like 1 [Rattus norvegicus]

Related Sequences to LMP012972 proteins

Reference Database Accession Length Protein Name
GI:189303567 GenBank EDL93647.1 1349 neuropathy target esterase like 1 [Rattus norvegicus]
GI:189303567 RefSeq NP_666363.3 1352 patatin-like phospholipase domain-containing protein 7 [Mus musculus]
GI:189303567 SwissProt A2AJ88.1 1352 RecName: Full=Patatin-like phospholipase domain-containing protein 7; AltName: Full=Neuropathy target esterase-related esterase; Short=NRE; Short=NTE-related esterase [Mus musculus]
GI:189303567 SwissProt Q5BK26.2 1349 RecName: Full=Patatin-like phospholipase domain-containing protein 7; AltName: Full=Liver NTE-related protein 1; AltName: Full=NTE-related esterase [Rattus norvegicus]