Gene/Proteome Database (LMPD)

LMPD ID
LMP012974
Gene ID
246263
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA synthetase medium-chain family member 2A
Gene Symbol
Acsm2a
Synonyms
KS; Acsm2;
Alternate Names
acyl-coenzyme A synthetase ACSM2, mitochondrial; butyrate--CoA ligase 2; kidney-specific protein KS; kidney-specific protein (KS); butyryl coenzyme A synthetase 2; butyryl-coenzyme A synthetase 2; middle-chain acyl-CoA synthetase 2; xenobiotic/medium-chain fatty acid:CoA ligase; acyl-CoA synthetase medium-chain family member 2;
Chromosome
1
Map Location
1q35
EC Number
6.2.1.2
Summary
may bind AMP; may be involved in kidney function [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acsm2a

Proteins

acyl-coenzyme A synthetase ACSM2, mitochondrial
Refseq ID NP_653349
Protein GI 21426769
UniProt ID O70490
mRNA ID NM_144748
Length 572
MHWLWKIPRLCTFWGTEMFHRSFHMNIKKLMPIQWGHQEVPAKFNFASDVIDHWASLEKAGKRSPGPALWWMNGSGEELKWNFRELSEISKQTANVLTGACGLQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTTQMKSTDILYRLQSSKARAIVAGDEVVQEVDAVAPDCSFLKIKLLVSEKNREGWLNFKALLKDASPIHQCVETVSQESAAIYFTSGTSGPPKMAEHSHCSLGLKAKMDAGWTGLGPSDTMWTISDTGWILNILGSFLEPWVLGTCIFVHLLPKFDPQTVLKVLSSYPINTLLGAPLIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLEIREIYGQTETGITCRVSRTMKVKPGYLGTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRPIGMFSGYVDNPKKTQANIRGDFWLLGDRGIKDTEGYFHFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPIRREVVKAFVVLAPEFLSHDQDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG
transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (O70490.2) calculated_mol_wt: 5787 peptide sequence: MHWLWKIPRLCTFWGTEMFHRSFHMNIKKLMPIQWGHQEVPAKFNF mat_peptide: 47..572 product: Acyl-coenzyme A synthetase ACSM2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O70490.2) calculated_mol_wt: 58363 peptide sequence: ASDVIDHWASLEKAGKRSPGPALWWMNGSGEELKWNFRELSEISKQTANVLTGACGLQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTTQMKSTDILYRLQSSKARAIVAGDEVVQEVDAVAPDCSFLKIKLLVSEKNREGWLNFKALLKDASPIHQCVETVSQESAAIYFTSGTSGPPKMAEHSHCSLGLKAKMDAGWTGLGPSDTMWTISDTGWILNILGSFLEPWVLGTCIFVHLLPKFDPQTVLKVLSSYPINTLLGAPLIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLEIREIYGQTETGITCRVSRTMKVKPGYLGTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRPIGMFSGYVDNPKKTQANIRGDFWLLGDRGIKDTEGYFHFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPIRREVVKAFVVLAPEFLSHDQDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTITGKIERAKLRAKEWKTSG

Gene Information

Entrez Gene ID
246263
Gene Name
acyl-CoA synthetase medium-chain family member 2A
Gene Symbol
Acsm2a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953723 Amino Acid conjugation
5953258 Biological oxidations
5953721 Conjugation of benzoate with glycine
5953722 Conjugation of carboxylic acids
5953882 Conjugation of phenylacetate with glutamine
5953724 Conjugation of salicylate with glycine
5953250 Metabolism
5953257 Phase II conjugation

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 2A
Protein Entry
ACSM2_RAT
UniProt ID
O70490
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Developmental Stage First detected in kidney from 1 week old rats. Not detectable in fetal kidney and in kidney from newborn rats
Enzyme Regulation Activated by monovalent cations, such as potassium, rubidium or ammonium
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)
Induction Down-regulated in kidneys from a strain of spontaneously hypertensive rats (SHR). Down-regulated after unilateral ureteral obstruction or unilateral nephrectomy
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Subcellular Location Mitochondrion matrix .
Subunit Monomer
Tissue Specificity Detected in kidney, in proximal tubules

Identical and Related Proteins

Unique RefSeq proteins for LMP012974 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21426769 RefSeq NP_653349 572 acyl-coenzyme A synthetase ACSM2, mitochondrial

Identical Sequences to LMP012974 proteins

Reference Database Accession Length Protein Name
GI:21426769 GenBank AAD05209.1 572 kidney-specific protein [Rattus norvegicus]

Related Sequences to LMP012974 proteins

Reference Database Accession Length Protein Name
GI:21426769 GenBank AAD05209.1 572 kidney-specific protein [Rattus norvegicus]
GI:21426769 GenBank EDM17658.1 572 kidney-specific protein (KS), isoform CRA_a [Rattus norvegicus]
GI:21426769 RefSeq XP_008757899.1 572 PREDICTED: acyl-coenzyme A synthetase ACSM2, mitochondrial isoform X1 [Rattus norvegicus]
GI:21426769 SwissProt O70490.2 572 RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Kidney-specific protein KS; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Rattus norvegicus]