Gene/Proteome Database (LMPD)

LMPD ID
LMP012976
Gene ID
246302
Species
Rattus norvegicus (Rat)
Gene Name
prenylcysteine oxidase 1
Gene Symbol
Pcyox1
Synonyms
Clp55;
Alternate Names
prenylcysteine oxidase; chloride ion pump-associated 55 kDa protein;
Chromosome
4
Map Location
4q34
EC Number
1.8.3.5
Summary
a Cl(-) pump subunit; involved in outwardly directed Cl(-) transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pcyox1

Proteins

prenylcysteine oxidase precursor
Refseq ID NP_659553
Protein GI 21489987
UniProt ID Q99ML5
mRNA ID NM_145085
Length 504
MGRFAATLVGSLFGLGLLLCGLGRLASAEPRAPPEKIAIVGAGIGGTSSAYYLRKKFGKDVKIDVFEREEIGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSVPASGGLVGVYNGKSLVFEESSWFIINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMYAIGGDDYVRLLNQTLRENLKKAGFSETFLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAADSNLWAVEGGNKVVCSGLLQASNSNLISGSVMSIEKTRTKQTGTPPKMYEVVYKTGSEIHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTLIKGELNSTLFSSRHKDQFGLSAILVTDDSDMFINSLSIVASVSHKEGPPPAVDGMHVWKTFSKDILTKEQISKLFLSYDYAVRKPWLSYPYYNPPQKCPSIILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQDDLYEKLKTEL
sig_peptide: 1..28 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2765 peptide sequence: MGRFAATLVGSLFGLGLLLCGLGRLASA mat_peptide: 29..504 product: Prenylcysteine oxidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99ML5.1) calculated_mol_wt: 53541 peptide sequence: EPRAPPEKIAIVGAGIGGTSSAYYLRKKFGKDVKIDVFEREEIGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSVPASGGLVGVYNGKSLVFEESSWFIINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMYAIGGDDYVRLLNQTLRENLKKAGFSETFLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAADSNLWAVEGGNKVVCSGLLQASNSNLISGSVMSIEKTRTKQTGTPPKMYEVVYKTGSEIHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTLIKGELNSTLFSSRHKDQFGLSAILVTDDSDMFINSLSIVASVSHKEGPPPAVDGMHVWKTFSKDILTKEQISKLFLSYDYAVRKPWLSYPYYNPPQKCPSIILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQDDLYEKLKTEL

Gene Information

Entrez Gene ID
246302
Gene Name
prenylcysteine oxidase 1
Gene Symbol
Pcyox1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0005886 IDA:RGD C plasma membrane
GO:0034361 IEA:Ensembl C very-low-density lipoprotein particle
GO:0008555 IMP:RGD F chloride-transporting ATPase activity
GO:0001735 IEA:UniProtKB-EC F prenylcysteine oxidase activity
GO:1902476 IMP:GOC P chloride transmembrane transport
GO:0006821 IMP:RGD P chloride transport
GO:0030327 IEA:Ensembl P prenylated protein catabolic process
GO:0030328 IEA:Ensembl P prenylcysteine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR010795 Prenylcysteine lyase
IPR017046 Prenylcysteine oxidase

UniProt Annotations

Entry Information

Gene Name
prenylcysteine oxidase 1
Protein Entry
PCYOX_RAT
UniProt ID
Q99ML5
Species
Rat

Comments

Comment Type Description
Catalytic Activity An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2).
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Function Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity)
Similarity Belongs to the prenylcysteine oxidase family
Subcellular Location Lysosome .
Tissue Specificity Expressed mainly in cerebrum

Identical and Related Proteins

Unique RefSeq proteins for LMP012976 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21489987 RefSeq NP_659553 504 prenylcysteine oxidase precursor

Identical Sequences to LMP012976 proteins

Reference Database Accession Length Protein Name
GI:21489987 GenBank AAK16548.1 504 chloride ion pump-associated 55 kDa protein [Rattus norvegicus]
GI:21489987 GenBank AAH78719.1 504 Prenylcysteine oxidase 1 [Rattus norvegicus]
GI:21489987 GenBank EDL91232.1 504 prenylcysteine oxidase 1, isoform CRA_a [Rattus norvegicus]
GI:21489987 SwissProt Q99ML5.1 504 RecName: Full=Prenylcysteine oxidase; AltName: Full=Chloride ion pump-associated 55 kDa protein; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012976 proteins

Reference Database Accession Length Protein Name
GI:21489987 GenBank AAK16548.1 504 chloride ion pump-associated 55 kDa protein [Rattus norvegicus]
GI:21489987 GenBank AAH78719.1 504 Prenylcysteine oxidase 1 [Rattus norvegicus]
GI:21489987 GenBank EDL91232.1 504 prenylcysteine oxidase 1, isoform CRA_a [Rattus norvegicus]
GI:21489987 SwissProt Q99ML5.1 504 RecName: Full=Prenylcysteine oxidase; AltName: Full=Chloride ion pump-associated 55 kDa protein; Flags: Precursor [Rattus norvegicus]