Gene/Proteome Database (LMPD)

LMPD ID
LMP012983
Gene ID
252924
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 2, group C, member 1
Gene Symbol
Nr2c1
Synonyms
Tr2; Psg4; TR2-11;
Alternate Names
nuclear receptor subfamily 2 group C member 1; testicular receptor 2; orphan receptor, TR2-11; orphan nuclear receptor TR2; pregnancy specific beta-1-glycoprotein 4; nuclear receptor subfamily 2, group H, member 1;
Chromosome
7
Map Location
7q13
Summary
mouse Nr2c1 exhibits transcription factor, subtilase, ligand-dependent nuclear receptor and steroid hormone activities [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr2c1

Proteins

nuclear receptor subfamily 2 group C member 1
Refseq ID NP_665723
Protein GI 21955144
UniProt ID Q8VIJ4
mRNA ID NM_145780
Length 590
MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQFILANHEGSTPGKVFLTTPDAAGVNQLFFASPDLSTPHLQLLTENSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSTGLLDSGMFVNIHPSGIKTEPALLMTPDKAESCQGDLGTLASVVTSLANLGKAKDLSHCGGDLPVVQSLRNGDTSFGAFHQDIQTNGDVSRAFDNLAKALTPGENPACQSPGESMEGSTHLIAGEPSCMEREGPLLSDSHVVFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSPERRKLLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIEKFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEPADYNSQIIGHSL

Gene Information

Entrez Gene ID
252924
Gene Name
nuclear receptor subfamily 2, group C, member 1
Gene Symbol
Nr2c1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016605 IEA:Ensembl C PML body
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0048386 IEA:Ensembl P positive regulation of retinoic acid receptor signaling pathway
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 2, group C, member 1
Protein Entry
NR2C1_RAT
UniProt ID
Q8VIJ4
Species
Rat

Comments

Comment Type Description
Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity)
Ptm Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-210, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-568 by PKC is important for protein stability and function as activator of RARB (By similarity)
Ptm Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity)
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Nucleus, PML body . Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation
Subunit Homodimer (By similarity). Heterodimer; with NR2C2 which is required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain); the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012983 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21955144 RefSeq NP_665723 590 nuclear receptor subfamily 2 group C member 1

Identical Sequences to LMP012983 proteins

Reference Database Accession Length Protein Name
GI:21955144 GenBank EDM16889.1 590 pregnancy specific beta-1-glycoprotein 4, isoform CRA_a [Rattus norvegicus]
GI:21955144 RefSeq XP_008763438.1 590 PREDICTED: nuclear receptor subfamily 2 group C member 1 isoform X1 [Rattus norvegicus]
GI:21955144 RefSeq XP_008763439.1 590 PREDICTED: nuclear receptor subfamily 2 group C member 1 isoform X1 [Rattus norvegicus]
GI:21955144 SwissProt Q8VIJ4.1 590 RecName: Full=Nuclear receptor subfamily 2 group C member 1; AltName: Full=Orphan nuclear receptor TR2; AltName: Full=Testicular receptor 2 [Rattus norvegicus]

Related Sequences to LMP012983 proteins

Reference Database Accession Length Protein Name
GI:21955144 GenBank EDM16889.1 590 pregnancy specific beta-1-glycoprotein 4, isoform CRA_a [Rattus norvegicus]
GI:21955144 RefSeq XP_008763438.1 590 PREDICTED: nuclear receptor subfamily 2 group C member 1 isoform X1 [Rattus norvegicus]
GI:21955144 RefSeq XP_008763439.1 590 PREDICTED: nuclear receptor subfamily 2 group C member 1 isoform X1 [Rattus norvegicus]
GI:21955144 SwissProt Q8VIJ4.1 590 RecName: Full=Nuclear receptor subfamily 2 group C member 1; AltName: Full=Orphan nuclear receptor TR2; AltName: Full=Testicular receptor 2 [Rattus norvegicus]