Gene/Proteome Database (LMPD)

LMPD ID
LMP012984
Gene ID
259221
Species
Rattus norvegicus (Rat)
Gene Name
oxysterol binding protein-like 1A
Gene Symbol
Osbpl1a
Alternate Names
oxysterol-binding protein-related protein 1; ORP-1; OSBP-related protein 1;
Chromosome
18
Map Location
chromosome:18
Summary
human homolog is a member of the family of eukaryotic intracellular lipid receptors and may be involved in vesicle transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Osbpl1a

Proteins

oxysterol-binding protein-related protein 1
Refseq ID NP_742020
Protein GI 25282421
UniProt ID Q8K4M9
mRNA ID NM_172023
Length 950
MNTEAEQQLLHHARNGNAEEVRKLLEAMARAEVVADIDCKGRSKSNLGWTPLHLACYFGHKQVVQDLLKAGAKVNMLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTVVNGSGQTAKEATHDKEIRQMLEAVERTQQRKLEELLLGAAREGRTAEVSALLSRPNPPDVNCSDQLGNTPLHCAAYRAHKQCVLKLLRSGADPSLKNKNDQKPLDLAHGTEMKHILVGNKVVHKALKRFEGPLWKSSRFFGWKLFWVVLEHGVLSWYRKQPDAVHNSYRQGCKHLTQAVCTVKPTDGCLFSVRCFDDTVHGFRVPKNSLQQSREKWLEAIEEHSAYSTHYCSQDQVTDDEEEDVASAMDLKESLARAQTCQQRLDREIYNFLKMIKECDVAKDMLPSFLQKADVLSEASRETCVALSDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELERSLVEGSPPVSILSEDEFYDALSGSESEGSLTCLEAVTARAFEENEVPANSGKHRMSEGKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKTSKQASTSEESDEMPVPDSESVFVIPGSALLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY

Gene Information

Entrez Gene ID
259221
Gene Name
oxysterol binding protein-like 1A
Gene Symbol
Osbpl1a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005770 ISS:UniProtKB C late endosome
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein-like 1A
Protein Entry
OSBL1_RAT
UniProt ID
Q8K4M9
Species
Rat

Comments

Comment Type Description
Function Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A
Similarity Belongs to the OSBP family
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Late endosome . Note=Co- localizes with RAB7A, RAB9A and LAMP1 in late endosomes
Subunit Interacts with VAPA. Interacts with the GTP-bound form of RAB7A (By similarity). Interacts with OAS1B (By similarity)
Tissue Specificity Detected in prostate and liver

Identical and Related Proteins

Unique RefSeq proteins for LMP012984 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25282421 RefSeq NP_742020 950 oxysterol-binding protein-related protein 1

Identical Sequences to LMP012984 proteins

Reference Database Accession Length Protein Name
GI:25282421 DBBJ BAC07227.1 950 oxysterol-binding protein [Rattus norvegicus]
GI:25282421 SwissProt Q8K4M9.1 950 RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1 [Rattus norvegicus]

Related Sequences to LMP012984 proteins

Reference Database Accession Length Protein Name
GI:25282421 DBBJ BAC07227.1 950 oxysterol-binding protein [Rattus norvegicus]
GI:25282421 GenBank EDL75020.1 950 oxysterol binding protein-like 1A, isoform CRA_b [Rattus norvegicus]
GI:25282421 GenBank EDL75021.1 950 oxysterol binding protein-like 1A, isoform CRA_b [Rattus norvegicus]
GI:25282421 SwissProt Q8K4M9.1 950 RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1 [Rattus norvegicus]