Gene/Proteome Database (LMPD)

LMPD ID
LMP012986
Gene ID
259274
Species
Rattus norvegicus (Rat)
Gene Name
N-myristoyltransferase 1
Gene Symbol
Nmt1
Alternate Names
glycylpeptide N-tetradecanoyltransferase 1; NMT 1; type I N-myristoyltransferase; peptide N-myristoyltransferase 1; myristoyl-CoA:protein N-myristoyltransferase 1;
Chromosome
10
Map Location
10q32.1
EC Number
2.3.1.97
Summary
catalyzes the transfer of a myristol group to an amino-terminal glycine residue; may play a role in response to cardiac injury [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nmt1

Proteins

glycylpeptide N-tetradecanoyltransferase 1
Refseq ID NP_683689
Protein GI 22507314
UniProt ID Q8K1Q0
mRNA ID NM_148891
Length 496
MADESETAVKLPAPSLPLMMEGNGNGHEHCSDCENEEDISHNRGGLSPANDTGAKKKKKKQKKKKEKGNDMDSTQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQFNLTPVMNQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

Gene Information

Entrez Gene ID
259274
Gene Name
N-myristoyltransferase 1
Gene Symbol
Nmt1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0015629 IEA:Ensembl C actin cytoskeleton
GO:0030054 IEA:Ensembl C cell junction
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005886 IEA:Ensembl C plasma membrane
GO:0004379 IEA:UniProtKB-EC F glycylpeptide N-tetradecanoyltransferase activity
GO:0019107 IDA:RGD F myristoyltransferase activity
GO:0006499 IEA:Ensembl P N-terminal protein myristoylation
GO:0001701 IEA:Ensembl P in utero embryonic development

REACTOME Pathway Links

REACTOME Pathway ID Description
5953659 Activation, myristolyation of BID and translocation to mitochondria
5953314 Apoptosis
5953253 Disease
5953382 Diseases associated with visual transduction
5953378 Inactivation, recovery and regulation of the phototransduction cascade
5953632 Intrinsic Pathway for Apoptosis
5953381 Signal Transduction
5953379 The phototransduction cascade
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR016181 Acyl-CoA N-acyltransferase
IPR000903 Myristoyl-CoA:protein N-myristoyltransferase
IPR022677 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal
IPR022676 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal
IPR022678 Myristoyl-CoA:protein N-myristoyltransferase, conserved site

UniProt Annotations

Entry Information

Gene Name
N-myristoyltransferase 1
Protein Entry
NMT1_RAT
UniProt ID
Q8K1Q0
Species
Rat

Comments

Comment Type Description
Catalytic Activity Tetradecanoyl-CoA + glycylpeptide = CoA + N- tetradecanoylglycylpeptide.
Function Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins
Similarity Belongs to the NMT family
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP012986 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22507314 RefSeq NP_683689 496 glycylpeptide N-tetradecanoyltransferase 1

Identical Sequences to LMP012986 proteins

Reference Database Accession Length Protein Name
GI:22507314 EMBL CAD37349.1 496 peptide N-myristoyltransferase 1 [Rattus norvegicus]
GI:22507314 GenBank AAH97277.1 496 N-myristoyltransferase 1 [Rattus norvegicus]
GI:22507314 GenBank EDM06248.1 496 N-myristoyltransferase 1, isoform CRA_b [Rattus norvegicus]
GI:22507314 SwissProt Q8K1Q0.1 496 RecName: Full=Glycylpeptide N-tetradecanoyltransferase 1; AltName: Full=Myristoyl-CoA:protein N-myristoyltransferase 1; Short=NMT 1; Short=Type I N-myristoyltransferase; AltName: Full=Peptide N-myristoyltransferase 1 [Rattus norvegicus]

Related Sequences to LMP012986 proteins

Reference Database Accession Length Protein Name
GI:22507314 EMBL CAD37349.1 496 peptide N-myristoyltransferase 1 [Rattus norvegicus]
GI:22507314 GenBank AAH97277.1 496 N-myristoyltransferase 1 [Rattus norvegicus]
GI:22507314 GenBank EDM06248.1 496 N-myristoyltransferase 1, isoform CRA_b [Rattus norvegicus]
GI:22507314 SwissProt Q8K1Q0.1 496 RecName: Full=Glycylpeptide N-tetradecanoyltransferase 1; AltName: Full=Myristoyl-CoA:protein N-myristoyltransferase 1; Short=NMT 1; Short=Type I N-myristoyltransferase; AltName: Full=Peptide N-myristoyltransferase 1 [Rattus norvegicus]