Gene/Proteome Database (LMPD)

LMPD ID
LMP012988
Gene ID
266603
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 1 family, member A3
Gene Symbol
Aldh1a3
Synonyms
Aldh6;
Alternate Names
aldehyde dehydrogenase family 1 member A3; ralDH3; RALDH-3; aldehyde dehydrogenase 6; retinaldehyde dehydrogenase 3; aldehyde dehydrogenase family 1, subfamily A3;
Chromosome
1
Map Location
1q22
EC Number
1.2.1.5

Proteins

aldehyde dehydrogenase family 1 member A3
Refseq ID NP_695212
Protein GI 23463283
UniProt ID Q8K4D8
mRNA ID NM_153300
Length 512
MATANGAVENGQPDGKPPALPRPIRNLEVKFTKIFINNDWHEPKSGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSRGQLLHQLADLIERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWADKIQGRTIPTDDNVMCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLASLIKEVGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGRNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRSVEFAKKRPVGDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRGLFIKPTVFSDVTDNMRIAKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWVNCYNAFYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLDEKNP

Gene Information

Entrez Gene ID
266603
Gene Name
aldehyde dehydrogenase 1 family, member A3
Gene Symbol
Aldh1a3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 NAS:RGD C cytosol
GO:0004030 IDA:RGD F aldehyde dehydrogenase [NAD(P)+] activity
GO:0001758 IMP:RGD F retinal dehydrogenase activity
GO:0001822 IEP:RGD P kidney development
GO:0021983 IEP:RGD P pituitary gland development
GO:0042493 IEP:RGD P response to drug
GO:0002138 IMP:RGD P retinoic acid biosynthetic process
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
ko00982 Drug metabolism - cytochrome P450
rno00982 Drug metabolism - cytochrome P450
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
ko00340 Histidine metabolism
rno00340 Histidine metabolism
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450
ko00360 Phenylalanine metabolism
rno00360 Phenylalanine metabolism
ko00350 Tyrosine metabolism
rno00350 Tyrosine metabolism
ko00410 beta-Alanine metabolism
rno00410 beta-Alanine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 1 family, member A3
Protein Entry
AL1A3_RAT
UniProt ID
Q8K4D8
Species
Rat

Comments

Comment Type Description
Catalytic Activity An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
Function Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity)
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the aldehyde dehydrogenase family
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP012988 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23463283 RefSeq NP_695212 512 aldehyde dehydrogenase family 1 member A3

Identical Sequences to LMP012988 proteins

Reference Database Accession Length Protein Name
GI:23463283 GenBank AAN03711.1 512 aldehyde dehydrogenase 6 [Rattus norvegicus]
GI:23463283 SwissProt Q8K4D8.1 512 RecName: Full=Aldehyde dehydrogenase family 1 member A3; AltName: Full=Aldehyde dehydrogenase 6; AltName: Full=Retinaldehyde dehydrogenase 3; Short=RALDH-3; Short=RalDH3 [Rattus norvegicus]

Related Sequences to LMP012988 proteins

Reference Database Accession Length Protein Name
GI:23463283 GenBank AAN03711.1 512 aldehyde dehydrogenase 6 [Rattus norvegicus]
GI:23463283 GenBank EDM08431.1 512 aldehyde dehydrogenase family 1, subfamily A3, isoform CRA_a [Rattus norvegicus]
GI:23463283 GenBank AAI66415.1 512 Aldehyde dehydrogenase 1 family, member A3 [Rattus norvegicus]
GI:23463283 SwissProt Q8K4D8.1 512 RecName: Full=Aldehyde dehydrogenase family 1 member A3; AltName: Full=Aldehyde dehydrogenase 6; AltName: Full=Retinaldehyde dehydrogenase 3; Short=RALDH-3; Short=RalDH3 [Rattus norvegicus]