Gene/Proteome Database (LMPD)

LMPD ID
LMP012993
Gene ID
266732
Species
Rattus norvegicus (Rat)
Gene Name
Niemann-Pick disease, type C1
Gene Symbol
Npc1
Synonyms
Cdig2;
Alternate Names
Niemann-Pick C1 protein;
Chromosome
18
Map Location
18p13
Summary
cadmium-inducible gene; transcription upregulated by cadmium [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Npc1

Proteins

Niemann-Pick C1 protein precursor
Refseq ID NP_705888
Protein GI 311771778
UniProt ID G3V7K5
mRNA ID NM_153624
Length 1278
MGAHHPALGLLLLLLLCPAQVFSQSCVWYGECGVAFGDKRYNCEYSGPPKPLPKDGYDLVQELCPGLFFGNVSLCCDVQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPETRENKTNVKELEYYVGRSFANAMYNACRDVEAPSSNEKALGLLCGRDARACNATNWIEYMFNKDNGQAPFTIIPVFSDLSVLGMEPMRNATKGCNESVDEVTGPCSCQDCSAVCGPKPQPPPPPVPWRILGLDAMYVIMWVAYMAFLVLFFGGLLAVWCHRRRYFVSEYTPIDSNIAFSSNSSDKGEASCCDPLGVAFDDCLRRMFTKWGAFCVRNPTCIIFFSLVFIAACSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNSSVHIYEPYPSGADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDNQVGDDFFVYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAWAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVLISYAVMFLYISLALGHIQSWNRVLVDSKISLGIAGILIVLSSVTCSLGIFSYIGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSFLGLDIKRQEKNRLDILCCVRGPDDGQESQASESYLFRFFKNAFAPFLLTDWLRPVVMAVFVGILSFSIAVVNKVEIGLDQSLSMPNDSYVIDYFKSLGQYLHSGPPVYFVLEEGYNYSSRRGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVTHQFCNASVIDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYSSAVNIMGDDTYIGATYFMTYHTILKTSADYIDALKKARLIASNITETMRSKGSDYRVFPYSVFYVFYEQYLTIIDDAIFNLSVSLGSIFLVTLVALGCELWSAVIMCLTIAMILVNMFGVMWLWGISLNAVSLVNLVMTCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKRHTTQERYKGTERERLLNF
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2415 peptide sequence: MGAHHPALGLLLLLLLCPAQVFS

Gene Information

Entrez Gene ID
266732
Gene Name
Niemann-Pick disease, type C1
Gene Symbol
Npc1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0005768 IEA:Ensembl C endosome
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005887 IEA:Ensembl C integral component of plasma membrane
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0045121 IEA:Ensembl C membrane raft
GO:0005635 IEA:Ensembl C nuclear envelope
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0007628 IEA:Ensembl P adult walking behavior
GO:0006914 IEA:Ensembl P autophagy
GO:0071404 IEA:Ensembl P cellular response to low-density lipoprotein particle stimulus
GO:0071383 IEA:Ensembl P cellular response to steroid hormone stimulus
GO:0033344 IEA:Ensembl P cholesterol efflux
GO:0006897 IEA:Ensembl P endocytosis
GO:0090150 IEA:Ensembl P establishment of protein localization to membrane
GO:0031579 IEA:Ensembl P membrane raft organization
GO:0060548 IMP:RGD P negative regulation of cell death
GO:0016242 IEA:Ensembl P negative regulation of macroautophagy
GO:0006486 IEA:Ensembl P protein glycosylation
GO:0046686 IDA:RGD P response to cadmium ion
GO:0042493 IEA:Ensembl P response to drug

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
rno04142 Lysosome

Domain Information

InterPro Annotations

Accession Description
IPR004765 Niemann-Pick C type protein
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
Niemann-Pick disease, type C1
Protein Entry
G3V7K5_RAT
UniProt ID
G3V7K5
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012993 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
311771778 RefSeq NP_705888 1278 Niemann-Pick C1 protein precursor

Identical Sequences to LMP012993 proteins

Reference Database Accession Length Protein Name
GI:311771778 GenBank EDL86695.1 1278 rCG41239 [Rattus norvegicus]

Related Sequences to LMP012993 proteins

Reference Database Accession Length Protein Name
GI:311771778 GenBank EDL01560.1 1277 Niemann Pick type C1 [Mus musculus]
GI:311771778 GenBank EDL86695.1 1278 rCG41239 [Rattus norvegicus]
GI:311771778 RefSeq NP_032746.2 1277 Niemann-Pick C1 protein precursor [Mus musculus]
GI:311771778 RefSeq XP_006254465.1 1277 PREDICTED: Niemann-Pick C1 protein isoform X1 [Rattus norvegicus]