Gene/Proteome Database (LMPD)

LMPD ID
LMP012994
Gene ID
266770
Species
Rattus norvegicus (Rat)
Gene Name
sterol O-acyltransferase 2
Gene Symbol
Soat2
Synonyms
Acat-2;
Alternate Names
sterol O-acyltransferase 2; cholesterol acyltransferase 2; acyl-CoA:cholesterol acyltransferase 2; acyl coenzyme A:cholesterol acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2;
Chromosome
7
Map Location
7q36
EC Number
2.3.1.26

Proteins

sterol O-acyltransferase 2
Refseq ID NP_714950
Protein GI 40254723
UniProt ID Q7TQM4
mRNA ID NM_153728
Length 524
MEPKAPQLRRRERQGEEQENGACGEGNTRTHRAPDLVQWTRHMEAVKTQCLEQAQRELAELMDRAIWEAVQAYPKQDRPLPSTASDSTRKTQELHPGKRKVFITRKSLLDELMGVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMMWVPMFLSTLLLPYQTLRLWARPRSGGAWTLGASLGCVLLAAHAAVLCVLPVHVSVKHELPPASRCVLVFEQVRFLMKSYSFLRETVPGIFCVRGGKGICTPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQALGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRQGRGAAMLGVFLVSALVHEYIFCFVLGFFYPVMLILFLVVGGLLNFTMNDRHTGPAWNILMWTFLFLGQGIQVSLYCQEWYARRHCPLPQPTFWELVTPRSWSCHP

Gene Information

Entrez Gene ID
266770
Gene Name
sterol O-acyltransferase 2
Gene Symbol
Soat2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034736 IEA:UniProtKB-EC F cholesterol O-acyltransferase activity
GO:0004772 IDA:RGD F sterol O-acyltransferase activity
GO:0008203 IDA:RGD P cholesterol metabolic process
GO:0007584 IEP:RGD P response to nutrient

KEGG Pathway Links

KEGG Pathway ID Description
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT
IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types

UniProt Annotations

Entry Information

Gene Name
sterol O-acyltransferase 2
Protein Entry
SOAT2_RAT
UniProt ID
Q7TQM4
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + cholesterol = CoA + cholesterol ester.
Function Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (By similarity)
Similarity Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit May form homo- or heterodimers

Identical and Related Proteins

Unique RefSeq proteins for LMP012994 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40254723 RefSeq NP_714950 524 sterol O-acyltransferase 2

Identical Sequences to LMP012994 proteins

Reference Database Accession Length Protein Name
GI:40254723 DBBJ BAC78210.1 524 acyl-coenzyme A:cholesterol acyltransferase-2 [Rattus norvegicus]
GI:40254723 SwissProt Q7TQM4.1 524 RecName: Full=Sterol O-acyltransferase 2; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2; Short=ACAT-2; AltName: Full=Cholesterol acyltransferase 2 [Rattus norvegicus]

Related Sequences to LMP012994 proteins

Reference Database Accession Length Protein Name
GI:40254723 DBBJ BAC00846.1 524 AcylCoA:Cholesterol Acyltransferase 2 [Rattus norvegicus]
GI:40254723 DBBJ BAC78210.1 524 acyl-coenzyme A:cholesterol acyltransferase-2 [Rattus norvegicus]
GI:40254723 GenBank EDL86862.1 524 sterol O-acyltransferase 2 [Rattus norvegicus]
GI:40254723 SwissProt Q7TQM4.1 524 RecName: Full=Sterol O-acyltransferase 2; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2; Short=ACAT-2; AltName: Full=Cholesterol acyltransferase 2 [Rattus norvegicus]