Gene/Proteome Database (LMPD)

LMPD ID
LMP012995
Gene ID
282636
Species
Rattus norvegicus (Rat)
Gene Name
inositol (myo)-1(or 4)-monophosphatase 2
Gene Symbol
Impa2
Alternate Names
inositol monophosphatase 2; IMP 2; IMPase 2; myo-inositol monophosphatase A2; inositol-1(or 4)-monophosphatase 2;
Chromosome
18
Map Location
18q12.1
EC Number
3.1.3.25
Summary
mouse homolog is an enzyme that catalyzes the synthesis of free myo-inositol from various myo-inositol monophosphates [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Impa2

Proteins

inositol monophosphatase 2
Refseq ID NP_757378
Protein GI 26449166
UniProt ID Q8CIN7
mRNA ID NM_172224
Length 290
MKPNSEEEEELVQGVGPWDECFEVAVQLALRAGQIIRKALTEEKHVSTKTSAADLVTETDHRVEDLIVSELRKRFPSHRFIAEEATASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVHQELEFGVIHHCTEERLYTGRRGQGAFCNGQRLQVSRETDLAKALVLTEIGPKRDPDTLKVFLSNMERLLHAKAHGVRVIGSSTLALCYLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMSCRVVAAGTREMAVLIAQALQTINYGRDDEK

Gene Information

Entrez Gene ID
282636
Gene Name
inositol (myo)-1(or 4)-monophosphatase 2
Gene Symbol
Impa2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0008934 IEA:UniProtKB-EC F inositol monophosphate 1-phosphatase activity
GO:0052832 IEA:UniProtKB-EC F inositol monophosphate 3-phosphatase activity
GO:0052833 IEA:UniProtKB-EC F inositol monophosphate 4-phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0046855 IEA:Ensembl P inositol phosphate dephosphorylation
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954516 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR020552 Inositol monophosphatase, Lithium-sensitive
IPR020550 Inositol monophosphatase, conserved site
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
inositol (myo)-1(or 4)-monophosphatase 2
Protein Entry
IMPA2_RAT
UniProt ID
Q8CIN7
Species
Rat

Comments

Comment Type Description
Catalytic Activity Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Function Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity)
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
Similarity Belongs to the inositol monophosphatase family

Identical and Related Proteins

Unique RefSeq proteins for LMP012995 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
26449166 RefSeq NP_757378 290 inositol monophosphatase 2

Identical Sequences to LMP012995 proteins

Reference Database Accession Length Protein Name
GI:26449166 EMBL CAI30714.1 290 unnamed protein product [Rattus norvegicus]
GI:26449166 GenBank AAH83544.1 290 Inositol (myo)-1(or 4)-monophosphatase 2 [Rattus norvegicus]
GI:26449166 GenBank EDM14721.1 290 inositol (myo)-1(or 4)-monophosphatase 2, isoform CRA_a [Rattus norvegicus]
GI:26449166 SwissProt Q8CIN7.1 290 RecName: Full=Inositol monophosphatase 2; Short=IMP 2; Short=IMPase 2; AltName: Full=Inositol-1(or 4)-monophosphatase 2; AltName: Full=Myo-inositol monophosphatase A2 [Rattus norvegicus]

Related Sequences to LMP012995 proteins

Reference Database Accession Length Protein Name
GI:26449166 EMBL CAI30714.1 290 unnamed protein product [Rattus norvegicus]
GI:26449166 GenBank AAN47010.1 290 myo-inositol monophosphatase 2 [Rattus norvegicus]
GI:26449166 GenBank AAH83544.1 290 Inositol (myo)-1(or 4)-monophosphatase 2 [Rattus norvegicus]
GI:26449166 SwissProt Q8CIN7.1 290 RecName: Full=Inositol monophosphatase 2; Short=IMP 2; Short=IMPase 2; AltName: Full=Inositol-1(or 4)-monophosphatase 2; AltName: Full=Myo-inositol monophosphatase A2 [Rattus norvegicus]