Gene/Proteome Database (LMPD)

LMPD ID
LMP012997
Gene ID
286896
Species
Rattus norvegicus (Rat)
Gene Name
sphingosine-1-phosphate lyase 1
Gene Symbol
Sgpl1
Synonyms
spl; S1PL; Spgl1;
Alternate Names
sphingosine-1-phosphate lyase 1; SPL 1; SP-lyase 1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase;
Chromosome
20
Map Location
20q11
EC Number
4.1.2.27
Summary
catalyzes the conversion of phosphorylated long chain bases into ethanolamine phosphate and a fatty aldehyde in sphingolipid catabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sgpl1

Proteins

sphingosine-1-phosphate lyase 1
Refseq ID NP_775139
Protein GI 27465561
UniProt ID Q8CHN6
mRNA ID NM_173116
Length 568
MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPESLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLERLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQGGIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR

Gene Information

Entrez Gene ID
286896
Gene Name
sphingosine-1-phosphate lyase 1
Gene Symbol
Sgpl1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016831 IEA:InterPro F carboxy-lyase activity
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0008117 ISS:UniProtKB F sphinganine-1-phosphate aldolase activity
GO:0033327 IEA:Ensembl P Leydig cell differentiation
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0097190 ISS:UniProtKB P apoptotic signaling pathway
GO:0006672 ISS:UniProtKB P ceramide metabolic process
GO:0008210 IEA:Ensembl P estrogen metabolic process
GO:0097194 IEA:Ensembl P execution phase of apoptosis
GO:0060325 IEA:Ensembl P face morphogenesis
GO:0006631 ISS:UniProtKB P fatty acid metabolic process
GO:0010761 IEA:Ensembl P fibroblast migration
GO:0030097 IEA:Ensembl P hemopoiesis
GO:0001822 IEA:Ensembl P kidney development
GO:0001553 IEA:Ensembl P luteinization
GO:0060021 IEA:Ensembl P palate development
GO:0048008 IEA:Ensembl P platelet-derived growth factor receptor signaling pathway
GO:0009791 IEA:Ensembl P post-embryonic development
GO:0040014 IEA:Ensembl P regulation of multicellular organism growth
GO:0048705 IEA:Ensembl P skeletal system morphogenesis
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0030149 ISS:UniProtKB P sphingolipid catabolic process
GO:0001570 IEA:Ensembl P vasculogenesis

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism
M00100 Sphingosine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954266 Sphingolipid de novo biosynthesis
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate lyase 1
Protein Entry
SGPL1_RAT
UniProt ID
Q8CHN6
Species
Rat

Comments

Comment Type Description
Catalytic Activity Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence= ;
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity)
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily
Subcellular Location Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012997 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27465561 RefSeq NP_775139 568 sphingosine-1-phosphate lyase 1

Identical Sequences to LMP012997 proteins

Reference Database Accession Length Protein Name
GI:27465561 RefSeq XP_008771092.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]
GI:27465561 RefSeq XP_008771093.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]
GI:27465561 RefSeq XP_008771094.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]
GI:27465561 RefSeq XP_008771095.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012997 proteins

Reference Database Accession Length Protein Name
GI:27465561 RefSeq XP_008771092.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]
GI:27465561 RefSeq XP_008771093.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]
GI:27465561 RefSeq XP_008771094.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]
GI:27465561 RefSeq XP_008771095.1 568 PREDICTED: sphingosine-1-phosphate lyase 1 isoform X1 [Rattus norvegicus]