Gene/Proteome Database (LMPD)
LMPD ID
LMP013022
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class X
Gene Symbol
Synonyms
RGD1307289;
Alternate Names
phosphatidylinositol-glycan biosynthesis class X protein; GPI-mannosyltransferase subunit;
Chromosome
11
Map Location
11q22
Summary
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. The protein is translated from a non-AUG translation initiation site. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| phosphatidylinositol-glycan biosynthesis class X protein precursor | |
|---|---|
| Refseq ID | NP_001094121 |
| Protein GI | 161377437 |
| UniProt ID | Q60GF7 |
| mRNA ID | NM_001100651 |
| Length | 252 |
| MAASALAWLLLWAAGLVGRLAADISDARFSDGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPTGLFVDPYELASLRERNITEAVMVSESFNLEAPSYLSTESAVLIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMHCDQEFPILKCWAQSEVAAPCSLKSEEICQWKNMQYKSILKNLTVQVPVGLTIHTSLVCSVTLLITVLCSTLILLAVFKYGHFSL | |
| sig_peptide: 1..22 calculated_mol_wt: 2226 peptide sequence: MAASALAWLLLWAAGLVGRLAA mat_peptide: 23..252 product: phosphatidylinositol-glycan biosynthesis class X protein calculated_mol_wt: 26189 peptide sequence: DISDARFSDGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPTGLFVDPYELASLRERNITEAVMVSESFNLEAPSYLSTESAVLIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMHCDQEFPILKCWAQSEVAAPCSLKSEEICQWKNMQYKSILKNLTVQVPVGLTIHTSLVCSVTLLITVLCSTLILLAVFKYGHFSL | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class X
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IEA:InterPro | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0006506 | IEA:UniProtKB-UniPathway | P | GPI anchor biosynthetic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013233 | Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1 |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class X
Protein Entry
PIGX_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Caution | PubMed:15635094 reported that the initiator methionine is coded by an unusual start codon, CTG |
| Function | Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM |
| Pathway | Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. |
| Ptm | N-glycosylated |
| Sequence Caution | Sequence=BAD61008.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence= ; |
| Similarity | Belongs to the PIGX family |
| Subcellular Location | Endoplasmic reticulum membrane ; Single-pass type I membrane protein . |
| Subunit | Interacts with PIGM. |
Identical and Related Proteins
Unique RefSeq proteins for LMP013022 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 161377437 | RefSeq | NP_001094121 | 252 | phosphatidylinositol-glycan biosynthesis class X protein precursor |
Identical Sequences to LMP013022 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP013022 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:161377437 | RefSeq | XP_005344963.1 | 413 | PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Microtus ochrogaster] |
| GI:161377437 | RefSeq | XP_005340354.1 | 391 | PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Ictidomys tridecemlineatus] |
| GI:161377437 | RefSeq | XP_006974635.1 | 382 | PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Peromyscus maniculatus bairdii] |
| GI:161377437 | RefSeq | XP_008836787.1 | 411 | PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Nannospalax galili] |