Gene/Proteome Database (LMPD)

LMPD ID
LMP013038
Gene ID
289456
Species
Rattus norvegicus (Rat)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 11
Gene Symbol
Hsd17b11
Synonyms
Dhrs8;
Alternate Names
estradiol 17-beta-dehydrogenase 11; 17bHSD11; 17betaHSD11; 17betaHSDXI; 17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; dehydrogenase/reductase SDR family member 8; dehydrogenase/reductase (SDR family) member 8;
Chromosome
14
Map Location
14p22
EC Number
1.1.1.-

Proteins

estradiol 17-beta-dehydrogenase 11 precursor
Refseq ID NP_001004209
Protein GI 51948390
UniProt ID Q6AYS8
mRNA ID NM_001004209
Length 298
MKYLLDLILLLPLLIVFCIESFIKRLIPKKKKSVAGEIVLITGAGHGIGRLTAYEFAKLNTKLVLWDINKNGIEETAAKCRKLGAQVHPFVVDCSQREEIYSAVRKVKEEVGDVSILVNNAGVVYTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMMKNNHGHVVTVASAAGHTVVPFLLAYCSSKFAAVGFHRALTDELAALGCTGVRTSCLCPNFINTGFIKNPSTNLGPTLEPEEVVEHLMHGILTNQKMIFVPGSIALLTVLERVFPERFLDVLKRRINVKFDAVVGYKDK
sig_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q6AYS8.1) calculated_mol_wt: 2463 peptide sequence: MKYLLDLILLLPLLIVFCIES mat_peptide: 22..298 product: Estradiol 17-beta-dehydrogenase 11 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6AYS8.1) calculated_mol_wt: 30493 peptide sequence: FIKRLIPKKKKSVAGEIVLITGAGHGIGRLTAYEFAKLNTKLVLWDINKNGIEETAAKCRKLGAQVHPFVVDCSQREEIYSAVRKVKEEVGDVSILVNNAGVVYTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMMKNNHGHVVTVASAAGHTVVPFLLAYCSSKFAAVGFHRALTDELAALGCTGVRTSCLCPNFINTGFIKNPSTNLGPTLEPEEVVEHLMHGILTNQKMIFVPGSIALLTVLERVFPERFLDVLKRRINVKFDAVVGYKDK

Gene Information

Entrez Gene ID
289456
Gene Name
hydroxysteroid (17-beta) dehydrogenase 11
Gene Symbol
Hsd17b11
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005811 IEA:Ensembl C lipid particle
GO:0016229 IEA:Ensembl F steroid dehydrogenase activity
GO:0006710 IEA:Ensembl P androgen catabolic process
GO:0006694 IEA:UniProtKB-KW P steroid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 11
Protein Entry
DHB11_RAT
UniProt ID
Q6AYS8
Species
Rat

Comments

Comment Type Description
Catalytic Activity Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.
Function Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity)
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP013038 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51948390 RefSeq NP_001004209 298 estradiol 17-beta-dehydrogenase 11 precursor

Identical Sequences to LMP013038 proteins

Reference Database Accession Length Protein Name
GI:51948390 GenBank AAH78929.1 298 Hydroxysteroid (17-beta) dehydrogenase 11 [Rattus norvegicus]
GI:51948390 RefSeq XP_006250689.1 298 PREDICTED: estradiol 17-beta-dehydrogenase 11 isoform X1 [Rattus norvegicus]
GI:51948390 RefSeq XP_006250691.1 298 PREDICTED: estradiol 17-beta-dehydrogenase 11 isoform X1 [Rattus norvegicus]
GI:51948390 SwissProt Q6AYS8.1 298 RecName: Full=Estradiol 17-beta-dehydrogenase 11; AltName: Full=17-beta-hydroxysteroid dehydrogenase 11; Short=17-beta-HSD 11; Short=17bHSD11; Short=17betaHSD11; AltName: Full=17-beta-hydroxysteroid dehydrogenase XI; Short=17-beta-HSD XI; Short=17betaHSDXI; AltName: Full=Dehydrogenase/reductase SDR family member 8; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013038 proteins

Reference Database Accession Length Protein Name
GI:51948390 GenBank AAH78929.1 298 Hydroxysteroid (17-beta) dehydrogenase 11 [Rattus norvegicus]
GI:51948390 RefSeq XP_006250689.1 298 PREDICTED: estradiol 17-beta-dehydrogenase 11 isoform X1 [Rattus norvegicus]
GI:51948390 RefSeq XP_006250691.1 298 PREDICTED: estradiol 17-beta-dehydrogenase 11 isoform X1 [Rattus norvegicus]
GI:51948390 SwissProt Q6AYS8.1 298 RecName: Full=Estradiol 17-beta-dehydrogenase 11; AltName: Full=17-beta-hydroxysteroid dehydrogenase 11; Short=17-beta-HSD 11; Short=17bHSD11; Short=17betaHSD11; AltName: Full=17-beta-hydroxysteroid dehydrogenase XI; Short=17-beta-HSD XI; Short=17betaHSDXI; AltName: Full=Dehydrogenase/reductase SDR family member 8; Flags: Precursor [Rattus norvegicus]