Gene/Proteome Database (LMPD)

LMPD ID
LMP013046
Gene ID
289950
Species
Rattus norvegicus (Rat)
Gene Name
pyruvate dehydrogenase (lipoamide) beta
Gene Symbol
Pdhb
Alternate Names
pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B;
Chromosome
15
Map Location
15p14
EC Number
1.2.4.1

Proteins

pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor
Refseq ID NP_001007621
Protein GI 56090293
UniProt ID P49432
mRNA ID NM_001007620
Length 359
MAAVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDDNPVVMLENELMYGVAFELPTEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
transit_peptide: 1..30 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P49432.2) calculated_mol_wt: 3159 peptide sequence: MAAVAGLVRGPLRQASGLLKRRFHRSAPAA mat_peptide: 31..359 product: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P49432.2) calculated_mol_wt: 35842 peptide sequence: VQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDDNPVVMLENELMYGVAFELPTEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI

Gene Information

Entrez Gene ID
289950
Gene Name
pyruvate dehydrogenase (lipoamide) beta
Gene Symbol
Pdhb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:RGD C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0045254 IDA:RGD C pyruvate dehydrogenase complex
GO:0004739 IDA:RGD F pyruvate dehydrogenase (acetyl-transferring) activity
GO:0004738 ISS:UniProtKB F pyruvate dehydrogenase activity
GO:0006086 IDA:RGD P acetyl-CoA biosynthetic process from pyruvate
GO:0006006 IEA:UniProtKB-KW P glucose metabolic process
GO:0006099 ISS:UniProtKB P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko00020 Citrate cycle (TCA cycle)
rno00020 Citrate cycle (TCA cycle)
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
rno04066 HIF-1 signaling pathway
rno01100 Metabolic pathways
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953268 Pyruvate metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5954047 Regulation of pyruvate dehydrogenase (PDH) complex
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR027110 Pyruvate dehydrogenase E1 component subunit beta
IPR029061 Thiamin diphosphate-binding fold
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR005475 Transketolase-like, pyrimidine-binding domain

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase (lipoamide) beta
Protein Entry
ODPB_RAT
UniProt ID
P49432
Species
Rat

Comments

Comment Type Description
Catalytic Activity Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence= ;
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle
Subcellular Location Mitochondrion matrix .
Subunit Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013046 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
56090293 RefSeq NP_001007621 359 pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor

Identical Sequences to LMP013046 proteins

Reference Database Accession Length Protein Name
GI:56090293 GenBank AAH79137.1 359 Pyruvate dehydrogenase (lipoamide) beta [Rattus norvegicus]
GI:56090293 RefSeq XP_006251816.1 359 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [Rattus norvegicus]
GI:56090293 SwissProt P49432.2 359 RecName: Full=Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Short=PDHE1-B; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013046 proteins

Reference Database Accession Length Protein Name
GI:56090293 GenBank AAH79137.1 359 Pyruvate dehydrogenase (lipoamide) beta [Rattus norvegicus]
GI:56090293 RefSeq XP_006251816.1 359 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [Rattus norvegicus]
GI:56090293 RefSeq XP_006994806.1 359 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial [Peromyscus maniculatus bairdii]
GI:56090293 SwissProt P49432.2 359 RecName: Full=Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Short=PDHE1-B; Flags: Precursor [Rattus norvegicus]