Gene/Proteome Database (LMPD)

LMPD ID
LMP013058
Gene ID
290651
Species
Rattus norvegicus (Rat)
Gene Name
inositol-3-phosphate synthase 1
Gene Symbol
Isyna1
Alternate Names
inositol-3-phosphate synthase 1; IPS 1; MIP synthase; MI-1-P synthase; myo-inositol-1-phosphate synthase; myo-inositol 1-phosphate synthase A1;
Chromosome
16
Map Location
16p14
EC Number
5.5.1.4

Proteins

inositol-3-phosphate synthase 1
Refseq ID NP_001013902
Protein GI 189163481
UniProt ID Q6AYK3
mRNA ID NM_001013880
Length 557
MEPAAEILVDSPDVIFGPEAIEARYEYRTTRVSREGGVLRVRPTATRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSLTQAGTVNLGLDGDGREVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCGLQEQLWPHMESLRPRPSVYIPEFIAANQTARADNLIPGTRAQQLEQIRKDIRDFRSSAGLDKVIVLWTANTERFCEVVPGRNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPLQFRSKEVTKSSVVDDMVQSNRVLYAPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDPEPQGFHPVLSVLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKMERPFPGIKPEEVKATSPLPCKKESTPATNGCTGDANGHTQAPTPELSTA

Gene Information

Entrez Gene ID
290651
Gene Name
inositol-3-phosphate synthase 1
Gene Symbol
Isyna1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004512 IEA:UniProtKB-EC F inositol-3-phosphate synthase activity
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954516 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR002587 Myo-inositol-1-phosphate synthase
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
inositol-3-phosphate synthase 1
Protein Entry
INO1_RAT
UniProt ID
Q6AYK3
Species
Rat

Comments

Comment Type Description
Catalytic Activity D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate.
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence= ;
Function Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
Similarity Belongs to the myo-inositol 1-phosphate synthase family
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP013058 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189163481 RefSeq NP_001013902 557 inositol-3-phosphate synthase 1

Identical Sequences to LMP013058 proteins

Reference Database Accession Length Protein Name
GI:189163481 GenBank EDL90710.1 557 similar to myo-inositol 1-phosphate synthase A1 [Rattus norvegicus]
GI:189163481 SwissProt Q6AYK3.2 557 RecName: Full=Inositol-3-phosphate synthase 1; Short=IPS 1; AltName: Full=Myo-inositol 1-phosphate synthase; Short=MI-1-P synthase; Short=MIP synthase [Rattus norvegicus]

Related Sequences to LMP013058 proteins

Reference Database Accession Length Protein Name
GI:189163481 DBBJ BAC37607.1 557 unnamed protein product [Mus musculus]
GI:189163481 GenBank EDL28844.1 557 myo-inositol 1-phosphate synthase A1 [Mus musculus]
GI:189163481 GenBank EDL90710.1 557 similar to myo-inositol 1-phosphate synthase A1 [Rattus norvegicus]
GI:189163481 SwissProt Q6AYK3.2 557 RecName: Full=Inositol-3-phosphate synthase 1; Short=IPS 1; AltName: Full=Myo-inositol 1-phosphate synthase; Short=MI-1-P synthase; Short=MIP synthase [Rattus norvegicus]