Gene/Proteome Database (LMPD)

LMPD ID
LMP013060
Gene ID
290823
Species
Rattus norvegicus (Rat)
Gene Name
ER lipid raft associated 2
Gene Symbol
Erlin2
Synonyms
Spfh2; RGD1309010;
Alternate Names
erlin-2; SPFH domain family, member 2; erlin-2 {ECO:0000250|UniProtKB:Q8BFZ9}; erlin2 {ECO:0000312|EMBL:AAI68668.1, ECO:0000312|RGD:1309010}; SPFH domain-containing protein 2 {ECO:0000250|UniProtKB:Q8BFZ9, ECO:0000312|EMBL:AAI68668.1}; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250|UniProtKB:Q8BFZ9}; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250|UniProtKB:Q8BFZ9, ECO:0000312|EMBL:AAI68668.1};
Chromosome
16
Map Location
16q12.4

Proteins

erlin-2
Refseq ID NP_001099558
Protein GI 157823984
UniProt ID B5DEH2
mRNA ID NM_001106088
Length 339
MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN

Gene Information

Entrez Gene ID
290823
Gene Name
ER lipid raft associated 2
Gene Symbol
Erlin2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043234 IEA:Ensembl C protein complex
GO:0030433 IEA:Ensembl P ER-associated ubiquitin-dependent protein catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR001107 Band 7 protein

UniProt Annotations

Entry Information

Gene Name
ER lipid raft associated 2
Protein Entry
ERLN2_RAT
UniProt ID
B5DEH2
Species
Rat

Comments

Comment Type Description
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (By similarity)
Similarity Belongs to the band 7/mec-2 family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein . Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane
Subunit Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 (By similarity). Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013060 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157823984 RefSeq NP_001099558 339 erlin-2

Identical Sequences to LMP013060 proteins

Reference Database Accession Length Protein Name
GI:157823984 GenBank AAI68668.1 339 ER lipid raft associated 2 [Rattus norvegicus]
GI:157823984 RefSeq XP_008769545.1 339 PREDICTED: erlin-2 isoform X1 [Rattus norvegicus]
GI:157823984 RefSeq XP_008769546.1 339 PREDICTED: erlin-2 isoform X1 [Rattus norvegicus]
GI:157823984 SwissProt B5DEH2.1 339 RecName: Full=Erlin-2; AltName: Full=Endoplasmic reticulum lipid raft-associated protein 2; AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; Short=SPFH domain-containing protein 2 [Rattus norvegicus]

Related Sequences to LMP013060 proteins

Reference Database Accession Length Protein Name
GI:157823984 GenBank EDM09088.1 339 SPFH domain family, member 2 (predicted) [Rattus norvegicus]
GI:157823984 GenBank AAI68668.1 339 ER lipid raft associated 2 [Rattus norvegicus]
GI:157823984 RefSeq XP_008769545.1 339 PREDICTED: erlin-2 isoform X1 [Rattus norvegicus]
GI:157823984 SwissProt B5DEH2.1 339 RecName: Full=Erlin-2; AltName: Full=Endoplasmic reticulum lipid raft-associated protein 2; AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; Short=SPFH domain-containing protein 2 [Rattus norvegicus]