Gene/Proteome Database (LMPD)

LMPD ID
LMP013073
Gene ID
291450
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 7 family, member A1
Gene Symbol
Aldh7a1
Synonyms
antiquitin;
Alternate Names
alpha-aminoadipic semialdehyde dehydrogenase; antiquitin-1; P6c dehydrogenase; alpha-AASA dehydrogenase; betaine aldehyde dehydrogenase; aldehyde dehydrogenase family 7 member A1; aldehyde dehydrogenase family 7, member A1; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease;
Chromosome
18
Map Location
18q12.1
EC Number
1.2.1.31

Proteins

alpha-aminoadipic semialdehyde dehydrogenase
Refseq ID NP_001258034
Protein GI 402766107
UniProt ID Q64057
mRNA ID NM_001271105
Length 539
MLRLARPLCVQTVKASKLSRLWSRPAALMSTLLIHHPQYAWLQDLGLREDNEGVFNGSWGGRGEVITTYCPANNEPIARVRQASMKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDALREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALMEQWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSIAVTKIIAKVLEDNLLPGAICSLTCGGADMGTAMARDERVNLLSFTGSTQVGKQVALMVQERFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRRLFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEGGTVVYGGKVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTALPLAQGIKFQ
transit_peptide: 1..26 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q64057.2) calculated_mol_wt: 2982 peptide sequence: MLRLARPLCVQTVKASKLSRLWSRPA mat_peptide: 27..539 product: Alpha-aminoadipic semialdehyde dehydrogenase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64057.2) calculated_mol_wt: 55785 peptide sequence: ALMSTLLIHHPQYAWLQDLGLREDNEGVFNGSWGGRGEVITTYCPANNEPIARVRQASMKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDALREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALMEQWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSIAVTKIIAKVLEDNLLPGAICSLTCGGADMGTAMARDERVNLLSFTGSTQVGKQVALMVQERFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRRLFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEGGTVVYGGKVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTALPLAQGIKFQ

Gene Information

Entrez Gene ID
291450
Gene Name
aldehyde dehydrogenase 7 family, member A1
Gene Symbol
Aldh7a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004043 IEA:UniProtKB-EC F L-aminoadipate-semialdehyde dehydrogenase activity
GO:0008802 IEA:UniProtKB-EC F betaine-aldehyde dehydrogenase activity
GO:0019285 IEA:UniProtKB-UniPathway P glycine betaine biosynthetic process from choline

KEGG Pathway Links

KEGG Pathway ID Description
ko00330 Arginine and proline metabolism
rno00330 Arginine and proline metabolism
ko00053 Ascorbate and aldarate metabolism
rno00053 Ascorbate and aldarate metabolism
ko01230 Biosynthesis of amino acids
rno01230 Biosynthesis of amino acids
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
M00135 GABA biosynthesis, eukaryotes, putrescine => GABA
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00260 Glycine, serine and threonine metabolism
rno00260 Glycine, serine and threonine metabolism
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
ko00340 Histidine metabolism
rno00340 Histidine metabolism
ko00300 Lysine biosynthesis
rno00300 Lysine biosynthesis
ko00310 Lysine degradation
rno00310 Lysine degradation
M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
rno01100 Metabolic pathways
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation
ko00410 beta-Alanine metabolism
rno00410 beta-Alanine metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953284 Lysine catabolism
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 7 family, member A1
Protein Entry
AL7A1_RAT
UniProt ID
Q64057
Species
Rat

Comments

Comment Type Description
Catalytic Activity (S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
Catalytic Activity An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Catalytic Activity Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Function Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity)
Pathway Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Similarity Belongs to the aldehyde dehydrogenase family
Subcellular Location Nucleus . Cytoplasm, cytosol {ECO:0000250}. Mitochondrion .
Subunit Homotetramer
Tissue Specificity Abundant in kidney, liver, cochlea and outer hair cells but not inner hair cells or vestibular type I hair cells. Very low levels in lung, brain, intestine and pancreas

Identical and Related Proteins

Unique RefSeq proteins for LMP013073 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
402766107 RefSeq NP_001258034 539 alpha-aminoadipic semialdehyde dehydrogenase

Identical Sequences to LMP013073 proteins

Reference Database Accession Length Protein Name
GI:402766107 GenBank EDM14489.1 539 aldehyde dehydrogenase family 7, member A1, isoform CRA_b [Rattus norvegicus]
GI:402766107 SwissProt Q64057.2 539 RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase; Short=Alpha-AASA dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 7 member A1; AltName: Full=Antiquitin-1; AltName: Full=Betaine aldehyde dehydrogenase; AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenase; Short=P6c dehydrogenase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013073 proteins

Reference Database Accession Length Protein Name
GI:402766107 DBBJ BAE40971.1 539 unnamed protein product [Mus musculus]
GI:402766107 GenBank EDM14489.1 539 aldehyde dehydrogenase family 7, member A1, isoform CRA_b [Rattus norvegicus]
GI:402766107 SwissProt Q64057.2 539 RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase; Short=Alpha-AASA dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 7 member A1; AltName: Full=Antiquitin-1; AltName: Full=Betaine aldehyde dehydrogenase; AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenase; Short=P6c dehydrogenase; Flags: Precursor [Rattus norvegicus]
GI:402766107 SwissProt Q9DBF1.4 539 RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase; Short=Alpha-AASA dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 7 member A1; AltName: Full=Antiquitin-1; AltName: Full=Betaine aldehyde dehydrogenase; AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenase; Short=P6c dehydrogenase; Flags: Precursor [Mus musculus]