Gene/Proteome Database (LMPD)
Proteins
| free fatty acid receptor 2 | |
|---|---|
| Refseq ID | NP_001005877 |
| Protein GI | 54312092 |
| UniProt ID | Q76EI6 |
| mRNA ID | NM_001005877 |
| Length | 330 |
| MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE | |
Gene Information
Entrez Gene ID
Gene Name
free fatty acid receptor 2
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042995 | IDA:RGD | C | cell projection |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | ISS:UniProtKB | C | plasma membrane |
| GO:0004930 | IDA:UniProtKB | F | G-protein coupled receptor activity |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0007186 | IDA:UniProtKB | P | G-protein coupled receptor signaling pathway |
| GO:0002752 | ISS:UniProtKB | P | cell surface pattern recognition receptor signaling pathway |
| GO:0071398 | IDA:UniProtKB | P | cellular response to fatty acid |
| GO:0045444 | ISS:UniProtKB | P | fat cell differentiation |
| GO:0042593 | ISS:UniProtKB | P | glucose homeostasis |
| GO:0002232 | ISS:UniProtKB | P | leukocyte chemotaxis involved in inflammatory response |
| GO:0019915 | ISS:UniProtKB | P | lipid storage |
| GO:0002385 | ISS:UniProtKB | P | mucosal immune response |
| GO:0002879 | ISS:UniProtKB | P | positive regulation of acute inflammatory response to non-antigenic stimulus |
| GO:0032722 | ISS:UniProtKB | P | positive regulation of chemokine production |
| GO:0002720 | ISS:UniProtKB | P | positive regulation of cytokine production involved in immune response |
| GO:2000484 | ISS:UniProtKB | P | positive regulation of interleukin-8 secretion |
| GO:0002673 | ISS:UniProtKB | P | regulation of acute inflammatory response |
| GO:0090276 | ISS:UniProtKB | P | regulation of peptide hormone secretion |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954122 | Class A/1 (Rhodopsin-like receptors) |
| 5954300 | Free fatty acid receptors |
| 5953653 | G alpha (q) signalling events |
| 5953642 | GPCR downstream signaling |
| 5953758 | GPCR ligand binding |
| 5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
| 5953381 | Signal Transduction |
| 5953391 | Signaling by GPCR |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5- trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes |
| Similarity | Belongs to the G-protein coupled receptor 1 family |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . |
| Subunit | Interacts with FCN1 (via Fibrinogen C-terminal domain) |
| Tissue Specificity | Detected in whole wall and separated mucosa in the distal ileum and colon. Expressed by enteroendocrine cells expressing peptide YY (PYY) (at protein level) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013094 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 54312092 | RefSeq | NP_001005877 | 330 | free fatty acid receptor 2 |
Identical Sequences to LMP013094 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:54312092 | RefSeq | XP_006228884.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
| GI:54312092 | RefSeq | XP_008757355.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
| GI:54312092 | RefSeq | XP_008757356.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
| GI:54312092 | RefSeq | XP_008757357.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
Related Sequences to LMP013094 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:54312092 | GenBank | EDM07706.1 | 330 | rCG53798, isoform CRA_a [Rattus norvegicus] |
| GI:54312092 | GenBank | EDM07707.1 | 330 | rCG53798, isoform CRA_a [Rattus norvegicus] |
| GI:54312092 | RefSeq | XP_008757355.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |
| GI:54312092 | RefSeq | XP_008757356.1 | 330 | PREDICTED: free fatty acid receptor 2 isoform X1 [Rattus norvegicus] |