Gene/Proteome Database (LMPD)
LMPD ID
LMP013110
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
estrogen related receptor, alpha
Gene Symbol
Synonyms
Errra; ERRalpha;
Alternate Names
steroid hormone receptor ERR1; ERR-alpha; orphan nuclear receptor; estrogen-related receptor alpha; estrogen-related receptor, alpha; nuclear receptor subfamily 3 group B member 1;
Chromosome
1
Map Location
1q43
Summary
estrogen related receptor, alpha [RGD, Feb 2006]
Orthologs
Proteins
| steroid hormone receptor ERR1 | |
|---|---|
| Refseq ID | NP_001008511 |
| Protein GI | 158187524 |
| UniProt ID | Q5QJV7 |
| mRNA ID | NM_001008511 |
| Length | 422 |
| MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD | |
Gene Information
Entrez Gene ID
Gene Name
estrogen related receptor, alpha
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0045171 | IEA:Ensembl | C | intercellular bridge |
| GO:0015630 | IEA:Ensembl | C | microtubule cytoskeleton |
| GO:0005730 | IEA:Ensembl | C | nucleolus |
| GO:0000978 | IEA:Ensembl | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding |
| GO:0001078 | IEA:Ensembl | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription |
| GO:0001077 | IEA:Ensembl | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
| GO:0043565 | ISS:UniProtKB | F | sequence-specific DNA binding |
| GO:0005496 | IEA:InterPro | F | steroid binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0051216 | IMP:RGD | P | cartilage development |
| GO:0045893 | IMP:RGD | P | positive regulation of transcription, DNA-templated |
| GO:0042127 | IMP:RGD | P | regulation of cell proliferation |
| GO:0030278 | IMP:RGD | P | regulation of ossification |
| GO:0045667 | IMP:RGD | P | regulation of osteoblast differentiation |
| GO:0045670 | IMP:RGD | P | regulation of osteoclast differentiation |
| GO:0006355 | ISS:UniProtKB | P | regulation of transcription, DNA-templated |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953288 | Fatty acid, triacylglycerol, and ketone body metabolism |
| 5953330 | Gene Expression |
| 5953833 | Generic Transcription Pathway |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953600 | Mitochondrial biogenesis |
| 5954147 | Nuclear Receptor transcription pathway |
| 5953601 | Organelle biogenesis and maintenance |
| 5954333 | PPARA activates gene expression |
| 5954222 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| 5953599 | Transcriptional activation of mitochondrial biogenesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR024178 | Oestrogen receptor/oestrogen-related receptor |
| IPR027289 | Oestrogen-related receptor |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. |
| Ptm | Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity |
| Ptm | Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding (By similarity) |
| Ptm | Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding (By similarity) |
| Sequence Caution | Sequence=AAI04702.1; Type=Erroneous initiation; Evidence= ; Sequence=AAQ17212.1; Type=Frameshift; Positions=408, 413; Evidence= ; |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily |
| Similarity | Contains 1 nuclear receptor DNA-binding domain |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Subunit | Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013110 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 158187524 | RefSeq | NP_001008511 | 422 | steroid hormone receptor ERR1 |
Identical Sequences to LMP013110 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:158187524 | GenBank | AAI38587.1 | 422 | Estrogen related receptor, alpha [Mus musculus] |
| GI:158187524 | GenBank | AAI71958.1 | 422 | Estrogen related receptor, alpha [Mus musculus] |
| GI:158187524 | SwissProt | Q5QJV7.2 | 422 | RecName: Full=Steroid hormone receptor ERR1; AltName: Full=Estrogen-related receptor alpha; Short=ERR-alpha; AltName: Full=Nuclear receptor subfamily 3 group B member 1 [Rattus norvegicus] |
| GI:158187524 | SwissProt | O08580.4 | 422 | RecName: Full=Steroid hormone receptor ERR1; AltName: Full=Estrogen receptor-like 1; AltName: Full=Estrogen-related receptor alpha; Short=ERR-alpha; AltName: Full=Nuclear receptor subfamily 3 group B member 1 [Mus musculus] |
Related Sequences to LMP013110 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:158187524 | DBBJ | BAE33690.1 | 422 | unnamed protein product [Mus musculus] |
| GI:158187524 | GenBank | AAI38587.1 | 422 | Estrogen related receptor, alpha [Mus musculus] |
| GI:158187524 | RefSeq | NP_031979.2 | 422 | steroid hormone receptor ERR1 [Mus musculus] |
| GI:158187524 | SwissProt | O08580.4 | 422 | RecName: Full=Steroid hormone receptor ERR1; AltName: Full=Estrogen receptor-like 1; AltName: Full=Estrogen-related receptor alpha; Short=ERR-alpha; AltName: Full=Nuclear receptor subfamily 3 group B member 1 [Mus musculus] |