Gene/Proteome Database (LMPD)

LMPD ID
LMP013123
Gene ID
294673
Species
Rattus norvegicus (Rat)
Gene Name
hexosaminidase B
Gene Symbol
Hexb
Alternate Names
beta-hexosaminidase subunit beta; hexosaminidase subunit B; beta-N-acetylhexosaminidase subunit beta; N-acetyl-beta-glucosaminidase subunit beta;
Chromosome
2
Map Location
2q12
EC Number
3.2.1.52

Proteins

beta-hexosaminidase subunit beta precursor
Refseq ID NP_001011946
Protein GI 58865470
UniProt ID Q6AXR4
mRNA ID NM_001011946
Length 537
MPGSPRRAPGLLLQALVAMVSLALVAPFGLQPALWPMPRSVQVFPRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHHGPAKFQDKPQLEKLLVFINLEPQCDAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVYQDAYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSWGKGQKNLLTPCFIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEVEFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSLKKSSIVWQDVFDDQVELQPGTVVEVWKSENYLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFEGSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLAVHRCRMVSRGIAAQPLFTGYCNYENKMEK
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2349 peptide sequence: MPGSPRRAPGLLLQALVAMVSLA mat_peptide: 24..537 product: Beta-hexosaminidase subunit beta experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6AXR4.1) calculated_mol_wt: 59197 peptide sequence: LVAPFGLQPALWPMPRSVQVFPRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHHGPAKFQDKPQLEKLLVFINLEPQCDAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVYQDAYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSWGKGQKNLLTPCFIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEVEFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSLKKSSIVWQDVFDDQVELQPGTVVEVWKSENYLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFEGSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLAVHRCRMVSRGIAAQPLFTGYCNYENKMEK

Gene Information

Entrez Gene ID
294673
Gene Name
hexosaminidase B
Gene Symbol
Hexb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IDA:RGD C lysosome
GO:0016231 IDA:RGD F beta-N-acetylglucosaminidase activity
GO:0030246 IDA:RGD F carbohydrate binding
GO:0015929 IDA:RGD F hexosaminidase activity
GO:0046982 IDA:RGD F protein heterodimerization activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0005975 IEA:InterPro P carbohydrate metabolic process
GO:0006044 IDA:RGD P N-acetylglucosamine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00520 Amino sugar and nucleotide sugar metabolism
rno00520 Amino sugar and nucleotide sugar metabolism
ko00531 Glycosaminoglycan degradation
rno00531 Glycosaminoglycan degradation
ko00604 Glycosphingolipid biosynthesis - ganglio series
rno00604 Glycosphingolipid biosynthesis - ganglio series
ko00603 Glycosphingolipid biosynthesis - globo series
rno00603 Glycosphingolipid biosynthesis - globo series
M00079 Keratan sulfate degradation
ko04142 Lysosome
rno04142 Lysosome
rno01100 Metabolic pathways
ko00511 Other glycan degradation
rno00511 Other glycan degradation

Domain Information

InterPro Annotations

Accession Description
IPR029019 Beta-hexosaminidase, eukaryotic type, N-terminal
IPR025705 Beta_hexosaminidase_sua/sub
IPR029018 Chitobiase/beta-hexosaminidase domain 2-like
IPR013781 Glycoside hydrolase, catalytic domain
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase superfamily

UniProt Annotations

Entry Information

Gene Name
hexosaminidase B
Protein Entry
HEXB_RAT
UniProt ID
Q6AXR4
Species
Rat

Comments

Comment Type Description
Catalytic Activity Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues
Similarity Belongs to the glycosyl hydrolase 20 family
Subcellular Location Lysosome .

Identical and Related Proteins

Unique RefSeq proteins for LMP013123 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865470 RefSeq NP_001011946 537 beta-hexosaminidase subunit beta precursor

Identical Sequences to LMP013123 proteins

Reference Database Accession Length Protein Name
GI:58865470 GenBank AAH79376.1 537 Hexosaminidase B [Rattus norvegicus]
GI:58865470 GenBank EDM10131.1 537 rCG44661, isoform CRA_b [Rattus norvegicus]
GI:58865470 SwissProt Q6AXR4.1 537 RecName: Full=Beta-hexosaminidase subunit beta; AltName: Full=Beta-N-acetylhexosaminidase subunit beta; Short=Hexosaminidase subunit B; AltName: Full=N-acetyl-beta-glucosaminidase subunit beta; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013123 proteins

Reference Database Accession Length Protein Name
GI:58865470 GenBank AAH79376.1 537 Hexosaminidase B [Rattus norvegicus]
GI:58865470 GenBank EDM10131.1 537 rCG44661, isoform CRA_b [Rattus norvegicus]
GI:58865470 GenBank EDM10132.1 508 rCG44661, isoform CRA_c [Rattus norvegicus]
GI:58865470 SwissProt Q6AXR4.1 537 RecName: Full=Beta-hexosaminidase subunit beta; AltName: Full=Beta-N-acetylhexosaminidase subunit beta; Short=Hexosaminidase subunit B; AltName: Full=N-acetyl-beta-glucosaminidase subunit beta; Flags: Precursor [Rattus norvegicus]